Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery

The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes...

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Detalhes bibliográficos
Autores: Marques, Joana, Valle Delgado, Juan José, Urbán, Patricia, Baró, Elisabet, Prohens López, Rafael, Mayor Aparicio, Alfredo Gabriel, Cisteró, Pau, Delves, Michael, Sinden, Robert E., Grandfils, Christian, Paz, José L. de, García Salcedo, José A., Fernàndez Busquets, Xavier
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/135361
Acesso em linha:https://hdl.handle.net/2445/135361
Access Level:acceso abierto
Palavra-chave:Malària
Nanomedicina
Malaria
Nanomedicine
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spelling Adaptation of targeted nanocarriers to changing requirements in antimalarial drug deliveryMarques, JoanaValle Delgado, Juan JoséUrbán, PatriciaBaró, ElisabetProhens López, RafaelMayor Aparicio, Alfredo GabrielCisteró, PauDelves, MichaelSinden, Robert E.Grandfils, ChristianPaz, José L. deGarcía Salcedo, José A.Fernàndez Busquets, XavierMalàriaNanomedicinaMalariaNanomedicineThe adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.Elsevier2019201920172019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/135361Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1016/j.nano.2016.09.010Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, num. 2, p. 515-525http://dx.doi.org/10.1016/j.nano.2016.09.010cc by (c) Marques et al., 2017http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1353612026-05-29T05:05:01Z
dc.title.none.fl_str_mv Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
title Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
spellingShingle Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Marques, Joana
Malària
Nanomedicina
Malaria
Nanomedicine
title_short Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
title_full Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
title_fullStr Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
title_full_unstemmed Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
title_sort Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
dc.creator.none.fl_str_mv Marques, Joana
Valle Delgado, Juan José
Urbán, Patricia
Baró, Elisabet
Prohens López, Rafael
Mayor Aparicio, Alfredo Gabriel
Cisteró, Pau
Delves, Michael
Sinden, Robert E.
Grandfils, Christian
Paz, José L. de
García Salcedo, José A.
Fernàndez Busquets, Xavier
author Marques, Joana
author_facet Marques, Joana
Valle Delgado, Juan José
Urbán, Patricia
Baró, Elisabet
Prohens López, Rafael
Mayor Aparicio, Alfredo Gabriel
Cisteró, Pau
Delves, Michael
Sinden, Robert E.
Grandfils, Christian
Paz, José L. de
García Salcedo, José A.
Fernàndez Busquets, Xavier
author_role author
author2 Valle Delgado, Juan José
Urbán, Patricia
Baró, Elisabet
Prohens López, Rafael
Mayor Aparicio, Alfredo Gabriel
Cisteró, Pau
Delves, Michael
Sinden, Robert E.
Grandfils, Christian
Paz, José L. de
García Salcedo, José A.
Fernàndez Busquets, Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Malària
Nanomedicina
Malaria
Nanomedicine
topic Malària
Nanomedicina
Malaria
Nanomedicine
description The adaptation of existing antimalarial nanocarriers to new Plasmodium stages, drugs, targeting molecules, or encapsulating structures is a strategy that can provide new nanotechnology-based, cost-efficient therapies against malaria. We have explored the modification of different liposome prototypes that had been developed in our group for the targeted delivery of antimalarial drugs to Plasmodium-infected red blood cells (pRBCs). These new models include: (i) immunoliposome-mediated release of new lipid-based antimalarials; (ii) liposomes targeted to pRBCs with covalently linked heparin to reduce anticoagulation risks; (iii) adaptation of heparin to pRBC targeting of chitosan nanoparticles; (iv) use of heparin for the targeting of Plasmodium stages in the mosquito vector; and (v) use of the non-anticoagulant glycosaminoglycan chondroitin 4-sulfate as a heparin surrogate for pRBC targeting. The results presented indicate that the tuning of existing nanovessels to new malaria-related targets is a valid low-cost alternative to the de novo development of targeted nanosystems.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/135361
url https://hdl.handle.net/2445/135361
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1016/j.nano.2016.09.010
Nanomedicine: Nanotechnology, Biology and Medicine, 2017, vol. 13, num. 2, p. 515-525
http://dx.doi.org/10.1016/j.nano.2016.09.010
dc.rights.none.fl_str_mv cc by (c) Marques et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Marques et al., 2017
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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