Tying malaria and microRNAs: from the biology to future diagnostic perspectives

Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assess...

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Detalhes bibliográficos
Autores: Rubio, Mercedes, Bassat Orellana, Quique, Estivill, Xavier, 1955-, Mayor Aparicio, Alfredo Gabriel
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2016
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/98678
Acesso em linha:https://hdl.handle.net/2445/98678
Access Level:Acceso aberto
Palavra-chave:Malària
Micro RNAs
Malaria
MicroRNAs
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spelling Tying malaria and microRNAs: from the biology to future diagnostic perspectivesRubio, MercedesBassat Orellana, QuiqueEstivill, Xavier, 1955-Mayor Aparicio, Alfredo GabrielMalàriaMicro RNAsMalariaMicroRNAsSymptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.BioMed Central2016201620162016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfhttps://hdl.handle.net/2445/98678Articles publicats en revistes (ISGlobal)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1186/s12936-016-1222-9Malaria Journal, 2016, vol. 15, num. 167, p. 1-14 p.http://dx.doi.org/10.1186/s12936-016-1222-9cc by (c) Rubio et al., 2016http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/986782026-05-29T05:05:01Z
dc.title.none.fl_str_mv Tying malaria and microRNAs: from the biology to future diagnostic perspectives
title Tying malaria and microRNAs: from the biology to future diagnostic perspectives
spellingShingle Tying malaria and microRNAs: from the biology to future diagnostic perspectives
Rubio, Mercedes
Malària
Micro RNAs
Malaria
MicroRNAs
title_short Tying malaria and microRNAs: from the biology to future diagnostic perspectives
title_full Tying malaria and microRNAs: from the biology to future diagnostic perspectives
title_fullStr Tying malaria and microRNAs: from the biology to future diagnostic perspectives
title_full_unstemmed Tying malaria and microRNAs: from the biology to future diagnostic perspectives
title_sort Tying malaria and microRNAs: from the biology to future diagnostic perspectives
dc.creator.none.fl_str_mv Rubio, Mercedes
Bassat Orellana, Quique
Estivill, Xavier, 1955-
Mayor Aparicio, Alfredo Gabriel
author Rubio, Mercedes
author_facet Rubio, Mercedes
Bassat Orellana, Quique
Estivill, Xavier, 1955-
Mayor Aparicio, Alfredo Gabriel
author_role author
author2 Bassat Orellana, Quique
Estivill, Xavier, 1955-
Mayor Aparicio, Alfredo Gabriel
author2_role author
author
author
dc.subject.none.fl_str_mv Malària
Micro RNAs
Malaria
MicroRNAs
topic Malària
Micro RNAs
Malaria
MicroRNAs
description Symptoms caused by bacterial, viral and malarial infections usually overlap and aetiologic diagnosis is difficult. Patient management in low-resource countries with limited laboratory services has been based predominantly on clinical evaluation and syndromic approaches. However, such clinical assessment has limited accuracy both for identifying the likely aetiological cause and for the early recognition of patients who will progress to serious or fatal disease. Plasma-detectable biomarkers that rapidly and accurately diagnose severe infectious diseases could reduce morbidity and decrease the unnecessary use of usually scarce therapeutic drugs. The discovery of microRNAs (miRNAs) has opened exciting new avenues to identify blood biomarkers of organ-specific injury. This review assesses current knowledge on the relationship between malaria disease and miRNAs, and evaluates how future research might lead to the use of these small molecules for identifying patients with severe malaria disease and facilitate treatment decisions.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016
2016
2016
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/98678
url https://hdl.handle.net/2445/98678
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-016-1222-9
Malaria Journal, 2016, vol. 15, num. 167, p. 1-14 p.
http://dx.doi.org/10.1186/s12936-016-1222-9
dc.rights.none.fl_str_mv cc by (c) Rubio et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Rubio et al., 2016
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv Articles publicats en revistes (ISGlobal)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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