A critical view on the current use of daptomycin in Spain: The daptomise study

Background: The Study on the Clinical Use of DAPTOMycin in Spain (DAPTOMISE Study) is a national surveillance program of daptomycin use. The objectives of this study are to evaluate the current variability in daptomycin consumption across the different hospitals and the adequacy of therapy, speciall...

ver descrição completa

Detalhes bibliográficos
Autores: Rodríguez González, Carmen Guadalupe, Chamorro de Vega, Esther, Villa Martínez, Sofía de la, Valerio, Maricela, Gutiérrez Urbón, José María, Giménez Manzorro, Álvaro, Fernández de Gamarra Martínez, Edurne, Cobo Sacristán, Sara, Bouza Santiago, Emilio, Herranz Alonso, Ana, Muñoz García de Paredes, Patricia, Sanjurjo Sáez, María
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/200833
Acesso em linha:https://hdl.handle.net/2445/200833
Access Level:acceso abierto
Palavra-chave:Antibiòtics
Posologia
Antibiotics
Posology
id ES_cf96d4cbf2ec1c30e64073f9a54d602c
oai_identifier_str oai:recercat.cat:2445/200833
network_acronym_str ES
network_name_str España
repository_id_str
spelling A critical view on the current use of daptomycin in Spain: The daptomise studyRodríguez González, Carmen GuadalupeChamorro de Vega, EstherVilla Martínez, Sofía de laValerio, MaricelaGutiérrez Urbón, José MaríaGiménez Manzorro, ÁlvaroFernández de Gamarra Martínez, EdurneCobo Sacristán, SaraBouza Santiago, EmilioHerranz Alonso, AnaMuñoz García de Paredes, PatriciaSanjurjo Sáez, MaríaAntibiòticsPosologiaAntibioticsPosologyBackground: The Study on the Clinical Use of DAPTOMycin in Spain (DAPTOMISE Study) is a national surveillance program of daptomycin use. The objectives of this study are to evaluate the current variability in daptomycin consumption across the different hospitals and the adequacy of therapy, specially focused on underdosing. Methods: All adult and pediatric patients who received, at least, one dose of daptomycin in a single week in 98 institutions in Spain were included. The adequacy of daptomycin use was evaluated with respect to the indication, dosage, adjustments after microbiology results, switching to an oral agent and length of treatment. Results: A total of 615 patients received daptomycin during the study week. The prevalence use was 2.3 patients / 100,000 inhabitants per week, 12.4 patients / 1000 admissions and 9.2 Days of Therapy (DOT) / 1000 hospital stays. These rates varied between hospitals: from 0 to 13.9 patients / 100,000 inhabitants, from 0 to 76.1 patients / 1000 admissions and from 0 to 49.4 DOT / 1000 hospital stays. The most frequent infections were bacteremia (31.6 %) and skin and soft tissue infections (17.9 %). Microbiological results were available in only 65.4 % of infections. The most frequent microorganisms were Staphylococcus aureus (192 isolates, of which 87 were resistant to methicillin) and coagulase-negative staphylococci (124 isolates). A total of 136 prescriptions (22.1 %) were underdosed. Dosages < 8 mg/kg were used for 35.6 % of endovascular infections and for 26.2 % of osteoarticular infections. Overall, 57.2 % of prescriptions were not optimal in, at least, one item. Clinical cure rate was 76.1% and mortality attributable to the infection 8.1%. Conclusion: This is the first registry that identifies the prevalence of use of daptomycin in Spain and shows a high variability in the consumption between the different hospitals. Daptomycin underdosing was present in more than 20 % of cases. (c) 2023 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Elsevier BV2023202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/200833Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.jiph.2023.05.008Journal of Infection and Public Health, 2023, vol. 16, num. 7, p. 1115-1122https://doi.org/10.1016/j.jiph.2023.05.008cc by-nc-nd (c) Rodríguez González, Carmen Guadalupe et al, 2023http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2008332026-05-29T05:05:01Z
dc.title.none.fl_str_mv A critical view on the current use of daptomycin in Spain: The daptomise study
title A critical view on the current use of daptomycin in Spain: The daptomise study
spellingShingle A critical view on the current use of daptomycin in Spain: The daptomise study
Rodríguez González, Carmen Guadalupe
Antibiòtics
Posologia
Antibiotics
Posology
title_short A critical view on the current use of daptomycin in Spain: The daptomise study
title_full A critical view on the current use of daptomycin in Spain: The daptomise study
title_fullStr A critical view on the current use of daptomycin in Spain: The daptomise study
title_full_unstemmed A critical view on the current use of daptomycin in Spain: The daptomise study
title_sort A critical view on the current use of daptomycin in Spain: The daptomise study
dc.creator.none.fl_str_mv Rodríguez González, Carmen Guadalupe
Chamorro de Vega, Esther
Villa Martínez, Sofía de la
Valerio, Maricela
Gutiérrez Urbón, José María
Giménez Manzorro, Álvaro
Fernández de Gamarra Martínez, Edurne
Cobo Sacristán, Sara
Bouza Santiago, Emilio
Herranz Alonso, Ana
Muñoz García de Paredes, Patricia
Sanjurjo Sáez, María
author Rodríguez González, Carmen Guadalupe
author_facet Rodríguez González, Carmen Guadalupe
Chamorro de Vega, Esther
Villa Martínez, Sofía de la
Valerio, Maricela
Gutiérrez Urbón, José María
Giménez Manzorro, Álvaro
Fernández de Gamarra Martínez, Edurne
Cobo Sacristán, Sara
Bouza Santiago, Emilio
Herranz Alonso, Ana
Muñoz García de Paredes, Patricia
Sanjurjo Sáez, María
author_role author
author2 Chamorro de Vega, Esther
Villa Martínez, Sofía de la
Valerio, Maricela
Gutiérrez Urbón, José María
Giménez Manzorro, Álvaro
Fernández de Gamarra Martínez, Edurne
Cobo Sacristán, Sara
Bouza Santiago, Emilio
Herranz Alonso, Ana
Muñoz García de Paredes, Patricia
Sanjurjo Sáez, María
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Antibiòtics
Posologia
Antibiotics
Posology
topic Antibiòtics
Posologia
Antibiotics
Posology
description Background: The Study on the Clinical Use of DAPTOMycin in Spain (DAPTOMISE Study) is a national surveillance program of daptomycin use. The objectives of this study are to evaluate the current variability in daptomycin consumption across the different hospitals and the adequacy of therapy, specially focused on underdosing. Methods: All adult and pediatric patients who received, at least, one dose of daptomycin in a single week in 98 institutions in Spain were included. The adequacy of daptomycin use was evaluated with respect to the indication, dosage, adjustments after microbiology results, switching to an oral agent and length of treatment. Results: A total of 615 patients received daptomycin during the study week. The prevalence use was 2.3 patients / 100,000 inhabitants per week, 12.4 patients / 1000 admissions and 9.2 Days of Therapy (DOT) / 1000 hospital stays. These rates varied between hospitals: from 0 to 13.9 patients / 100,000 inhabitants, from 0 to 76.1 patients / 1000 admissions and from 0 to 49.4 DOT / 1000 hospital stays. The most frequent infections were bacteremia (31.6 %) and skin and soft tissue infections (17.9 %). Microbiological results were available in only 65.4 % of infections. The most frequent microorganisms were Staphylococcus aureus (192 isolates, of which 87 were resistant to methicillin) and coagulase-negative staphylococci (124 isolates). A total of 136 prescriptions (22.1 %) were underdosed. Dosages < 8 mg/kg were used for 35.6 % of endovascular infections and for 26.2 % of osteoarticular infections. Overall, 57.2 % of prescriptions were not optimal in, at least, one item. Clinical cure rate was 76.1% and mortality attributable to the infection 8.1%. Conclusion: This is the first registry that identifies the prevalence of use of daptomycin in Spain and shows a high variability in the consumption between the different hospitals. Daptomycin underdosing was present in more than 20 % of cases. (c) 2023 Published by Elsevier Ltd on behalf of King Saud Bin Abdulaziz University for Health Sciences. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/200833
url https://hdl.handle.net/2445/200833
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.jiph.2023.05.008
Journal of Infection and Public Health, 2023, vol. 16, num. 7, p. 1115-1122
https://doi.org/10.1016/j.jiph.2023.05.008
dc.rights.none.fl_str_mv cc by-nc-nd (c) Rodríguez González, Carmen Guadalupe et al, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Rodríguez González, Carmen Guadalupe et al, 2023
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420097087471616
score 15.198674

Registos relacionados