Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm

In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old...

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Autores: Mochol, Gabriela, Kiryk, Anna, Filipkowski, Robert K., Wawrzyniak, Marcin, Lioudyno, Victoria, Knapska, Ewelina, Gorkiewicz, Tomasz, Balcerzyk, Marcin, Leski, Szymon, Van Leuven, Fred, Lipp, Hans-Peter, Wójcik, Daniel K., Kaczmarek, Leszek
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2011
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/35238
Acceso en línea:http://hdl.handle.net/10230/35238
http://dx.doi.org/10.2174/156720511798192745
Access Level:acceso abierto
Palabra clave:Circadian rhythm
Group learning
Individual learning
IntelliCage
Social behavior
Amyloid precursor protein
IntelliCage system
Ageing
Sensorimotor
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spelling Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythmMochol, GabrielaKiryk, AnnaMochol, GabrielaFilipkowski, Robert K.Wawrzyniak, MarcinLioudyno, VictoriaKnapska, EwelinaGorkiewicz, TomaszBalcerzyk, MarcinLeski, SzymonVan Leuven, FredLipp, Hans-PeterWójcik, Daniel K.Kaczmarek, LeszekCircadian rhythmGroup learningIndividual learningIntelliCageSocial behaviorAmyloid precursor proteinIntelliCage systemAgeingSensorimotorIn the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.This work was supported by MemStick grant (7 Frame-work Program of EU), the NCCR “Neural Plasticity and Re-pair” and Swiss National Science Foundation.Bentham Science Publishers201820182011info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35238http://dx.doi.org/10.2174/156720511798192745reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésCognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.© Bentham Science Publishers. Article published in Kiryk A, Mochol G, Filipkowski RK, Wawrzyniak M, Lioudyno V, Knapska E, Gorkiewicz T, Balcerzyk M, Leski S, Van Leuven F, Lipp HP, Wójcik DK, Kaczmarek L. Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.. The published manuscript is available at EurekaSelect via http://www.eurekaselect.com/89141/articleinfo:eu-repo/semantics/openAccessoai:recercat.cat:10230/352382026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
title Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
spellingShingle Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
Mochol, Gabriela
Circadian rhythm
Group learning
Individual learning
IntelliCage
Social behavior
Amyloid precursor protein
IntelliCage system
Ageing
Sensorimotor
title_short Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
title_full Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
title_fullStr Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
title_full_unstemmed Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
title_sort Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm
dc.creator.none.fl_str_mv Mochol, Gabriela
Kiryk, Anna
Mochol, Gabriela
Filipkowski, Robert K.
Wawrzyniak, Marcin
Lioudyno, Victoria
Knapska, Ewelina
Gorkiewicz, Tomasz
Balcerzyk, Marcin
Leski, Szymon
Van Leuven, Fred
Lipp, Hans-Peter
Wójcik, Daniel K.
Kaczmarek, Leszek
author Mochol, Gabriela
author_facet Mochol, Gabriela
Kiryk, Anna
Filipkowski, Robert K.
Wawrzyniak, Marcin
Lioudyno, Victoria
Knapska, Ewelina
Gorkiewicz, Tomasz
Balcerzyk, Marcin
Leski, Szymon
Van Leuven, Fred
Lipp, Hans-Peter
Wójcik, Daniel K.
Kaczmarek, Leszek
author_role author
author2 Kiryk, Anna
Filipkowski, Robert K.
Wawrzyniak, Marcin
Lioudyno, Victoria
Knapska, Ewelina
Gorkiewicz, Tomasz
Balcerzyk, Marcin
Leski, Szymon
Van Leuven, Fred
Lipp, Hans-Peter
Wójcik, Daniel K.
Kaczmarek, Leszek
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Circadian rhythm
Group learning
Individual learning
IntelliCage
Social behavior
Amyloid precursor protein
IntelliCage system
Ageing
Sensorimotor
topic Circadian rhythm
Group learning
Individual learning
IntelliCage
Social behavior
Amyloid precursor protein
IntelliCage system
Ageing
Sensorimotor
description In the present study, we used a new training paradigm in the intelliCage automatic behavioral assessment system to investigate cognitive functions of the transgenic mice harboring London mutation of the human amyloid precursor protein (APP.V717I). Three groups of animals: 5-, 12- and 18-24-month old were subjected to both Water Maze training and the IntelliCage-based appetitive conditioning. The spatial memory deficit was observed in all three groups of transgenic mice in both behavioral paradigms. However, the APP mice were capable to learn normally when co-housed with the wild-type (WT) littermates, in contrast to clearly impaired learning observed when the transgenic mice were housed alone. Furthermore, in the transgenic mice kept in the Intellicage alone, the cognitive deficit of the young animals was modulated by the circadian rhythm, namely was prominent only during the active phase of the day. The novel approach to study the transgenic mice cognitive abilities presented in this paper offers new insight into cognitive dysfunctions of the Alzheimers disease mouse model.
publishDate 2011
dc.date.none.fl_str_mv 2011
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35238
http://dx.doi.org/10.2174/156720511798192745
url http://hdl.handle.net/10230/35238
http://dx.doi.org/10.2174/156720511798192745
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Cognitive abilities of Alzheimer's disease transgenic mice are modulated by social context and circadian rhythm. Current Alzheimer Research. 2011;8(8):883-92.
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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