New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalaria...
| Autores: | , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Universidad de Navarra |
| Repositorio: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglés |
| OAI Identifier: | oai:dadun.unav.edu:10171/29506 |
| Acceso en línea: | https://hdl.handle.net/10171/29506 |
| Access Level: | acceso abierto |
| Palabra clave: | Quinoxaline 1,4-di-N-oxide Leishmanicidal Antiplasmodial |
| id |
ES_cf7547acbbc8a3907b73020009e7b7ec |
|---|---|
| oai_identifier_str |
oai:dadun.unav.edu:10171/29506 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activitiesBarea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223dPabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fdGonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95bMonge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618Quinoxaline1,4-di-N-oxideLeishmanicidalAntiplasmodialMalaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position.MDPIDadun. Depósito Académico Digital Universidad de Navarra20132013-07-1820132013-01-0120132013-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/29506reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/295062026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| spellingShingle |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Quinoxaline 1,4-di-N-oxide Leishmanicidal Antiplasmodial |
| title_short |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_full |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_fullStr |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_full_unstemmed |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| title_sort |
New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities |
| dc.creator.none.fl_str_mv |
Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 |
| author |
Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d |
| author_facet |
Barea, C. (Carlos)|||/items/4f4c9d7c-4235-491b-9444-7a90d51c223d Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 |
| author_role |
author |
| author2 |
Pabon, A. (Adriana)|||/items/49b4dd33-b935-4fa8-bfc7-8bb9e2a92b49 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd Gonzalez, G. (Germán)|||/items/c2dc077d-6791-48a8-ae3e-3b6e5bded95b Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Deharo, E. (Eric)|||/items/48bf3a09-fa0f-4898-8f39-dce9f0fcdef9 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Quinoxaline 1,4-di-N-oxide Leishmanicidal Antiplasmodial |
| topic |
Quinoxaline 1,4-di-N-oxide Leishmanicidal Antiplasmodial |
| description |
Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position. |
| publishDate |
2013 |
| dc.date.none.fl_str_mv |
2013 2013-07-18 2013 2013-01-01 2013 2013-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/29506 |
| url |
https://hdl.handle.net/10171/29506 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
MDPI |
| publisher.none.fl_str_mv |
MDPI |
| dc.source.none.fl_str_mv |
reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
| reponame_str |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| collection |
Dadun. Depósito Académico Digital de la Universidad de Navarra |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869420084886241280 |
| score |
15.300724 |