IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients

Background: Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF...

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Autores: Deira, J., Suárez, M. A., López, F., García-Cabrera, E., Gascón, A., Torregrosa, E., García Rodríguez, Giannina Elena, Huertas, J., de la Flor, J. C., PUELLO MARTINEZ, SULEYKA, Gómez-Raja, J., Grande, J., Lerma, J. L., Corradino, C., Musso, C., Martín, J., Basile, C., Casino, F.G.
Tipo de documento: artigo
Data de publicação:2019
País:España
Recursos:Servizo Galego de Saúde (SERGAS)
Repositório:RUNA. Repositorio da Consellería de Sanidade e Sergas
OAI Identifier:oai:runa.sergas.gal:20.500.11940/15417
Acesso em linha:https://www.ncbi.nlm.nih.gov/pubmed/30626347
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325813/pdf/12882_2018_Article_1189.pdf
http://hdl.handle.net/20.500.11940/15417
Access Level:Acceso aberto
Palavra-chave:Kidney
Humans
Creatinine
Multicenter Studies as Topic
Prospective Studies
Urea
Renal Dialysis
Randomized Controlled Trials as Topic
diálisis renal
estudios prospectivos
riñón
estudios multicéntricos como asunto
humanos
ensayos clínicos controlados aleatorizados como asunto
urea
creatinina
CHUF
CHUS
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repository_id_str
spelling IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patientsDeira, J.Suárez, M. A.López, F.García-Cabrera, E.Gascón, A.Torregrosa, E.García Rodríguez, Giannina ElenaHuertas, J.de la Flor, J. C.PUELLO MARTINEZ, SULEYKAGómez-Raja, J.Grande, J.Lerma, J. L.Corradino, C.Musso, C.Martín, J.Basile, C.Casino, F.G.KidneyHumansCreatinineMulticenter Studies as TopicProspective StudiesUreaRenal DialysisRandomized Controlled Trials as Topicdiálisis renalestudios prospectivosriñónestudios multicéntricos como asuntohumanosensayos clínicos controlados aleatorizados como asuntoureacreatininaCHUFCHUSBackground: Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF, whenever compared with conventional hemodialysis. The objective of the present controlled randomized trial (RCT) is to determine if start HD with one sessions per week (1-Wk/HD), it is associated with better patient survival and other safety parameters. Methods/design: IHDIP is a multicenter RCT experimental open trial. It is randomized in a 1:1 ratio and controlled through usual clinical practice, with a low intervention level and non-commercial. It includes 152 incident patients older than 18 years, with a RRF of ≥4 ml/min/1.73 m2, measured by renal clearance of urea (KrU). The intervention group includes 76 patients who will start with incremental HD (1-Wk/HD). The control group includes 76 patients who will start with thrice-weekly hemodialysis régimen. The primary outcome is assessing the survival rate, while the secondary outcomes are the morbidity rate, the clinical parameters, the quality of life and the efficiency. Discussion: This study will enable to know the number of sessions a patient should receive when starting HD, depending on his RRF. The potentially important clinical and financial implications of incremental hemodialysis warrant this RCT. Trial registration: U.S. National Institutes of Health, ClinicalTrials.gov . Number: NCT03239808 , completed 13/04/2017. Sponsor: Foundation for Training and Research of Health Professionals of Extremadura.2019info:eu-repo/semantics/articlehttps://www.ncbi.nlm.nih.gov/pubmed/30626347https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325813/pdf/12882_2018_Article_1189.pdfhttp://hdl.handle.net/20.500.11940/15417reponame:RUNA. Repositorio da Consellería de Sanidade e Sergasinstname:Servizo Galego de Saúde (SERGAS)Ingléshttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:runa.sergas.gal:20.500.11940/154172026-06-12T08:40:47Z
dc.title.none.fl_str_mv IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
title IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
spellingShingle IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
Deira, J.
Kidney
Humans
Creatinine
Multicenter Studies as Topic
Prospective Studies
Urea
Renal Dialysis
Randomized Controlled Trials as Topic
diálisis renal
estudios prospectivos
riñón
estudios multicéntricos como asunto
humanos
ensayos clínicos controlados aleatorizados como asunto
urea
creatinina
CHUF
CHUS
title_short IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
title_full IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
title_fullStr IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
title_full_unstemmed IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
title_sort IHDIP: a controlled randomized trial to assess the security and effectiveness of the incremental hemodialysis in incident patients
dc.creator.none.fl_str_mv Deira, J.
Suárez, M. A.
López, F.
García-Cabrera, E.
Gascón, A.
Torregrosa, E.
García Rodríguez, Giannina Elena
Huertas, J.
de la Flor, J. C.
PUELLO MARTINEZ, SULEYKA
Gómez-Raja, J.
Grande, J.
Lerma, J. L.
Corradino, C.
Musso, C.
Martín, J.
Basile, C.
Casino, F.G.
author Deira, J.
author_facet Deira, J.
Suárez, M. A.
López, F.
García-Cabrera, E.
Gascón, A.
Torregrosa, E.
García Rodríguez, Giannina Elena
Huertas, J.
de la Flor, J. C.
PUELLO MARTINEZ, SULEYKA
Gómez-Raja, J.
Grande, J.
Lerma, J. L.
Corradino, C.
Musso, C.
Martín, J.
Basile, C.
Casino, F.G.
author_role author
author2 Suárez, M. A.
López, F.
García-Cabrera, E.
Gascón, A.
Torregrosa, E.
García Rodríguez, Giannina Elena
Huertas, J.
de la Flor, J. C.
PUELLO MARTINEZ, SULEYKA
Gómez-Raja, J.
Grande, J.
Lerma, J. L.
Corradino, C.
Musso, C.
Martín, J.
Basile, C.
Casino, F.G.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Kidney
Humans
Creatinine
Multicenter Studies as Topic
Prospective Studies
Urea
Renal Dialysis
Randomized Controlled Trials as Topic
diálisis renal
estudios prospectivos
riñón
estudios multicéntricos como asunto
humanos
ensayos clínicos controlados aleatorizados como asunto
urea
creatinina
CHUF
CHUS
topic Kidney
Humans
Creatinine
Multicenter Studies as Topic
Prospective Studies
Urea
Renal Dialysis
Randomized Controlled Trials as Topic
diálisis renal
estudios prospectivos
riñón
estudios multicéntricos como asunto
humanos
ensayos clínicos controlados aleatorizados como asunto
urea
creatinina
CHUF
CHUS
description Background: Most people who make the transition to renal replacement therapy (RRT) are treated with a fixed dose thrice-weekly hemodialysis réegimen, without considering their residual kidney function (RKF). Recent papers inform us that incremental hemodialysis is associated with preservation of RKF, whenever compared with conventional hemodialysis. The objective of the present controlled randomized trial (RCT) is to determine if start HD with one sessions per week (1-Wk/HD), it is associated with better patient survival and other safety parameters. Methods/design: IHDIP is a multicenter RCT experimental open trial. It is randomized in a 1:1 ratio and controlled through usual clinical practice, with a low intervention level and non-commercial. It includes 152 incident patients older than 18 years, with a RRF of ≥4 ml/min/1.73 m2, measured by renal clearance of urea (KrU). The intervention group includes 76 patients who will start with incremental HD (1-Wk/HD). The control group includes 76 patients who will start with thrice-weekly hemodialysis régimen. The primary outcome is assessing the survival rate, while the secondary outcomes are the morbidity rate, the clinical parameters, the quality of life and the efficiency. Discussion: This study will enable to know the number of sessions a patient should receive when starting HD, depending on his RRF. The potentially important clinical and financial implications of incremental hemodialysis warrant this RCT. Trial registration: U.S. National Institutes of Health, ClinicalTrials.gov . Number: NCT03239808 , completed 13/04/2017. Sponsor: Foundation for Training and Research of Health Professionals of Extremadura.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://www.ncbi.nlm.nih.gov/pubmed/30626347
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325813/pdf/12882_2018_Article_1189.pdf
http://hdl.handle.net/20.500.11940/15417
url https://www.ncbi.nlm.nih.gov/pubmed/30626347
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325813/pdf/12882_2018_Article_1189.pdf
http://hdl.handle.net/20.500.11940/15417
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:RUNA. Repositorio da Consellería de Sanidade e Sergas
instname:Servizo Galego de Saúde (SERGAS)
instname_str Servizo Galego de Saúde (SERGAS)
reponame_str RUNA. Repositorio da Consellería de Sanidade e Sergas
collection RUNA. Repositorio da Consellería de Sanidade e Sergas
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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