Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder

Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, sub...

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Autores: Requena-Ocaña, Nerea, Araos, Pedro, Flores, María, García-Marchena, Nuria, Silva-Peña, Daniel, Aranda, Jesús, Rivera, Patricia, Ruiz, Juan Jesús, Serrano, Antonia, Pavón, Francisco Javier, Suárez, Juan, Rodríguez de Fonseca, Fernando
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18424
Acceso en línea:http://hdl.handle.net/20.500.12105/18424
Access Level:acceso abierto
Palabra clave:Neuroscience
Psychology
Biomarkers
Neurociencias
Psicología
Biomarcadores
Alcohol Abstinence
Alcohol Drinking
Alcoholism
Brain-Derived Neurotrophic Factor
Cognitive Reserve
Comorbidity
Female
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Nurses, Male
Middle Aged
Multivariate Analysis
Principal Component Analysis
Educational Status
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spelling Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorderRequena-Ocaña, NereaAraos, PedroFlores, MaríaGarcía-Marchena, NuriaSilva-Peña, DanielAranda, JesúsRivera, PatriciaRuiz, Juan JesúsSerrano, AntoniaPavón, Francisco JavierSuárez, JuanRodríguez de Fonseca, FernandoNeurosciencePsychologyBiomarkersNeurocienciasPsicologíaBiomarcadoresAlcohol AbstinenceAlcohol DrinkingAlcoholismBrain-Derived Neurotrophic FactorCognitive ReserveComorbidityFemaleHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IInsulin-Like Growth Factor IINurses, MaleMiddle AgedMultivariate AnalysisPrincipal Component AnalysisEducational StatusCognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function.Springer[Requena-Ocaña,N; Araos,P; Flores,M; García-Marchena,N; Silva-Peña,D; Aranda,J; Rivera,P; Serrano,A; Pavón,FJ; Suárez,J; Rodríguez de Fonseca,F] Mental Health Clinical Management Unit, Institute of Biomedical Research of Malaga-IBIMA, Regional University. [Requena-Ocaña,N] School of Psychology, Complutense University of Madrid, Madrid, Spain. [Araos,P] Department of Psychobiology and Methodology of Behavioral Sciences, School of Psychology, University of Málaga, Málaga, Spain. [Aranda,J] School of Medicine, University of Málaga, Málaga, Spain. [Ruiz,JJ] Provincial Drug Addiction Center of Málaga, Provincial Council of Málaga, Málaga, Spain. [Pavón,FJ] Cardiac Clinical Management Unit, IBIMA, University Hospital Virgen de la Victoria, Málaga, Spain. [Suárez,J] Department of Human Anatomy, Legal Medicine and History of Science, IBIMA, Facultad de Medicina, University of Málaga, Málaga, Spain. [Requena-Ocaña,N] Laboratorio de Investigación, IBIMA, Hospital Universitario Regional de Málaga, Málaga, Spain.20242024-02-1920212021-08-0220212021-08-02research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18424reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/184242026-06-12T12:43:37Z
dc.title.none.fl_str_mv Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
spellingShingle Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
Requena-Ocaña, Nerea
Neuroscience
Psychology
Biomarkers
Neurociencias
Psicología
Biomarcadores
Alcohol Abstinence
Alcohol Drinking
Alcoholism
Brain-Derived Neurotrophic Factor
Cognitive Reserve
Comorbidity
Female
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Nurses, Male
Middle Aged
Multivariate Analysis
Principal Component Analysis
Educational Status
title_short Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_full Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_fullStr Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_full_unstemmed Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
title_sort Evaluation of neurotrophic factors and education level as predictors of cognitive decline in alcohol use disorder
dc.creator.none.fl_str_mv Requena-Ocaña, Nerea
Araos, Pedro
Flores, María
García-Marchena, Nuria
Silva-Peña, Daniel
Aranda, Jesús
Rivera, Patricia
Ruiz, Juan Jesús
Serrano, Antonia
Pavón, Francisco Javier
Suárez, Juan
Rodríguez de Fonseca, Fernando
author Requena-Ocaña, Nerea
author_facet Requena-Ocaña, Nerea
Araos, Pedro
Flores, María
García-Marchena, Nuria
Silva-Peña, Daniel
Aranda, Jesús
Rivera, Patricia
Ruiz, Juan Jesús
Serrano, Antonia
Pavón, Francisco Javier
Suárez, Juan
Rodríguez de Fonseca, Fernando
author_role author
author2 Araos, Pedro
Flores, María
García-Marchena, Nuria
Silva-Peña, Daniel
Aranda, Jesús
Rivera, Patricia
Ruiz, Juan Jesús
Serrano, Antonia
Pavón, Francisco Javier
Suárez, Juan
Rodríguez de Fonseca, Fernando
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv [Requena-Ocaña,N; Araos,P; Flores,M; García-Marchena,N; Silva-Peña,D; Aranda,J; Rivera,P; Serrano,A; Pavón,FJ; Suárez,J; Rodríguez de Fonseca,F] Mental Health Clinical Management Unit, Institute of Biomedical Research of Malaga-IBIMA, Regional University. [Requena-Ocaña,N] School of Psychology, Complutense University of Madrid, Madrid, Spain. [Araos,P] Department of Psychobiology and Methodology of Behavioral Sciences, School of Psychology, University of Málaga, Málaga, Spain. [Aranda,J] School of Medicine, University of Málaga, Málaga, Spain. [Ruiz,JJ] Provincial Drug Addiction Center of Málaga, Provincial Council of Málaga, Málaga, Spain. [Pavón,FJ] Cardiac Clinical Management Unit, IBIMA, University Hospital Virgen de la Victoria, Málaga, Spain. [Suárez,J] Department of Human Anatomy, Legal Medicine and History of Science, IBIMA, Facultad de Medicina, University of Málaga, Málaga, Spain. [Requena-Ocaña,N] Laboratorio de Investigación, IBIMA, Hospital Universitario Regional de Málaga, Málaga, Spain.
dc.subject.none.fl_str_mv Neuroscience
Psychology
Biomarkers
Neurociencias
Psicología
Biomarcadores
Alcohol Abstinence
Alcohol Drinking
Alcoholism
Brain-Derived Neurotrophic Factor
Cognitive Reserve
Comorbidity
Female
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Nurses, Male
Middle Aged
Multivariate Analysis
Principal Component Analysis
Educational Status
topic Neuroscience
Psychology
Biomarkers
Neurociencias
Psicología
Biomarcadores
Alcohol Abstinence
Alcohol Drinking
Alcoholism
Brain-Derived Neurotrophic Factor
Cognitive Reserve
Comorbidity
Female
Humans
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I
Insulin-Like Growth Factor II
Nurses, Male
Middle Aged
Multivariate Analysis
Principal Component Analysis
Educational Status
description Cognitive reserve (CR) is the capability of an individual to cope with a brain pathology through compensatory mechanisms developed through cognitive stimulation by mental and physical activity. Recently, it has been suggested that CR has a protective role against the initiation of substance use, substance consumption patterns and cognitive decline and can improve responses to treatment. However, CR has never been linked to cognitive function and neurotrophic factors in the context of alcohol consumption. The present cross-sectional study aims to evaluate the association between CR (evaluated by educational level), cognitive impairment (assessed using a frontal and memory loss assessment battery) and circulating levels of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in patients with alcohol use disorder (AUD). Our results indicated that lower educational levels were accompanied by earlier onset of alcohol consumption and earlier development of alcohol dependence, as well as impaired frontal cognitive function. They also suggest that CR, NT-3 and BDNF may act as compensatory mechanisms for cognitive decline in the early stages of AUD, but not in later phases. These parameters allow the identification of patients with AUD who are at risk of cognitive deterioration and the implementation of personalized interventions to preserve cognitive function.
publishDate 2021
dc.date.none.fl_str_mv 2021
2021-08-02
2021
2021-08-02
2024
2024-02-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18424
url http://hdl.handle.net/20.500.12105/18424
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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