H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury

The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%–8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient’s risk of developing intracranial lesions. The S100B p...

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Autores: Lagerstedt, Linnéa, Egea-Guerrero, Juan José, Bustamante, Alejandro, Montaner, Joan, Rodríguez-Rodríguez, Ana, El Rahal, Amir, Turck, Natacha, Quintana-Díaz, Manuel, García-Armengol, Roser, Melinda Prica, Carmen, Andereggen, Elisabeth, Rinaldi, Lara, Sarrafzadeh, Asita, Schaller, Karl, Sanchez, Jean-Charles
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/180771
Acceso en línea:http://hdl.handle.net/10261/180771
Access Level:acceso abierto
Palabra clave:ddc:616.8
ddc:613
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spelling H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injuryLagerstedt, LinnéaEgea-Guerrero, Juan JoséBustamante, AlejandroMontaner, JoanRodríguez-Rodríguez, AnaEl Rahal, AmirTurck, NatachaQuintana-Díaz, ManuelGarcía-Armengol, RoserMelinda Prica, CarmenAndereggen, ElisabethRinaldi, LaraSarrafzadeh, AsitaSchaller, KarlSanchez, Jean-Charlesddc:616.8ddc:613The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%–8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient’s risk of developing intracranial lesions. The S100B protein is currently the most studied and promising biomarker for this purpose. Heart fatty-acid binding protein (H-FABP) has been highlighted in brain injury models and investigated as a biomarker for stroke and severe TBI, for example. Here, we evaluate the performances of S100B and H-FABP for differentiating between CT-positive and CT-negative patients. A total of 261 patients with a GCS score of 15 and at least one clinical symptom of mTBI were recruited at three different European sites. Blood samples from 172 of them were collected ≤ 6 h after trauma. Patients underwent a CT scan and were dichotomised into CT-positive and CT-negative groups for statistical analyses. H-FABP and S100B levels were measured using commercial kits, and their capacities to detect all CT-positive scans were evaluated, with sensitivity set to 100%. For patients recruited ≤ 6 h after trauma, the CT-positive group demonstrated significantly higher levels of both H-FABP (p = 0.004) and S100B (p = 0.003) than the CT-negative group. At 100% sensitivity, specificity reached 6% (95% CI 2.8–10.7) for S100B and 29% (95% CI 21.4–37.1) for H-FABP. Similar results were obtained when including all the patients recruited, i.e. hospital arrival within 24 h of trauma onset. H-FABP out-performed S100B and thus seems to be an interesting protein for detecting all CT-positive mTBI patients with a GCS score of 15 and at least one clinical symptom.Peer reviewedPublic Library of ScienceConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]201920192017info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/180771reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Ingléshttps://doi.org/10.1371/journal.pone.0175572Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1807712026-05-22T06:33:51Z
dc.title.none.fl_str_mv H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
title H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
spellingShingle H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
Lagerstedt, Linnéa
ddc:616.8
ddc:613
title_short H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
title_full H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
title_fullStr H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
title_full_unstemmed H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
title_sort H-FABP: A new biomarker to differentiate between CT-positive and CT-negative patients with mild traumatic brain injury
dc.creator.none.fl_str_mv Lagerstedt, Linnéa
Egea-Guerrero, Juan José
Bustamante, Alejandro
Montaner, Joan
Rodríguez-Rodríguez, Ana
El Rahal, Amir
Turck, Natacha
Quintana-Díaz, Manuel
García-Armengol, Roser
Melinda Prica, Carmen
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles
author Lagerstedt, Linnéa
author_facet Lagerstedt, Linnéa
Egea-Guerrero, Juan José
Bustamante, Alejandro
Montaner, Joan
Rodríguez-Rodríguez, Ana
El Rahal, Amir
Turck, Natacha
Quintana-Díaz, Manuel
García-Armengol, Roser
Melinda Prica, Carmen
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles
author_role author
author2 Egea-Guerrero, Juan José
Bustamante, Alejandro
Montaner, Joan
Rodríguez-Rodríguez, Ana
El Rahal, Amir
Turck, Natacha
Quintana-Díaz, Manuel
García-Armengol, Roser
Melinda Prica, Carmen
Andereggen, Elisabeth
Rinaldi, Lara
Sarrafzadeh, Asita
Schaller, Karl
Sanchez, Jean-Charles
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv ddc:616.8
ddc:613
topic ddc:616.8
ddc:613
description The majority of patients with mild traumatic brain injury (mTBI) will have normal Glasgow coma scale (GCS) of 15. Furthermore, only 5%–8% of them will be CT-positive for an mTBI. Having a useful biomarker would help clinicians evaluate a patient’s risk of developing intracranial lesions. The S100B protein is currently the most studied and promising biomarker for this purpose. Heart fatty-acid binding protein (H-FABP) has been highlighted in brain injury models and investigated as a biomarker for stroke and severe TBI, for example. Here, we evaluate the performances of S100B and H-FABP for differentiating between CT-positive and CT-negative patients. A total of 261 patients with a GCS score of 15 and at least one clinical symptom of mTBI were recruited at three different European sites. Blood samples from 172 of them were collected ≤ 6 h after trauma. Patients underwent a CT scan and were dichotomised into CT-positive and CT-negative groups for statistical analyses. H-FABP and S100B levels were measured using commercial kits, and their capacities to detect all CT-positive scans were evaluated, with sensitivity set to 100%. For patients recruited ≤ 6 h after trauma, the CT-positive group demonstrated significantly higher levels of both H-FABP (p = 0.004) and S100B (p = 0.003) than the CT-negative group. At 100% sensitivity, specificity reached 6% (95% CI 2.8–10.7) for S100B and 29% (95% CI 21.4–37.1) for H-FABP. Similar results were obtained when including all the patients recruited, i.e. hospital arrival within 24 h of trauma onset. H-FABP out-performed S100B and thus seems to be an interesting protein for detecting all CT-positive mTBI patients with a GCS score of 15 and at least one clinical symptom.
publishDate 2017
dc.date.none.fl_str_mv 2017
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/180771
url http://hdl.handle.net/10261/180771
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv https://doi.org/10.1371/journal.pone.0175572
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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