The role of microglia in the spread of Tau: Relevance for tauopathies

Tauopathies are neurodegenerative diseases which course with the accumulation of Tau, mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated form. This protein is released into the extracellular space and spreads following a stereotypical pattern, inducing the develo...

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Detalles Bibliográficos
Autores: Perea, Juan Ramón, Llorens-Martín, María, Ávila, Jesús, Bolós, Marta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/182406
Acceso en línea:http://hdl.handle.net/10261/182406
Access Level:acceso abierto
Palabra clave:Phagocytosis
Tau protein
Alzheimer’s disease
Tauopathies
Microglia
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spelling The role of microglia in the spread of Tau: Relevance for tauopathiesPerea, Juan RamónLlorens-Martín, MaríaÁvila, JesúsBolós, MartaPhagocytosisTau proteinAlzheimer’s diseaseTauopathiesMicrogliaTauopathies are neurodegenerative diseases which course with the accumulation of Tau, mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated form. This protein is released into the extracellular space and spreads following a stereotypical pattern, inducing the development of the disease through connected regions of the brain. Microglia—the macrophages of the brain—are involved in maintaining brain homeostasis. They perform a variety of functions related to the surveillance and clearance of pathological proteins, among other dead cells and debris, from the extracellular space that could compromise brain equilibrium. This review focuses on the role played by microglia in tauopathies, specifically in Alzheimer’s disease (AD), and how the uncoupling of activation/phagocytosis functions can have fatal consequences leading to the development of the pathology.Spanish Ministry of Economy and Competitiveness (SAF-2014-53040-P (JÁ); SAF-2017-82185-R (ML-M)); the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED, Spain, JÁ); the Alzheimer’s Association AARG-17-528125 (ML-M); Institutional grants from the Fundación Ramón Areces and Banco de Santander to the CBMSOPeer ReviewedCentro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)Fundación Banco SantanderFundación Ramón ArecesAlzheimer's AssociationMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2019201920182019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/182406reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)InglésSíinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1824062026-05-22T06:33:51Z
dc.title.none.fl_str_mv The role of microglia in the spread of Tau: Relevance for tauopathies
title The role of microglia in the spread of Tau: Relevance for tauopathies
spellingShingle The role of microglia in the spread of Tau: Relevance for tauopathies
Perea, Juan Ramón
Phagocytosis
Tau protein
Alzheimer’s disease
Tauopathies
Microglia
title_short The role of microglia in the spread of Tau: Relevance for tauopathies
title_full The role of microglia in the spread of Tau: Relevance for tauopathies
title_fullStr The role of microglia in the spread of Tau: Relevance for tauopathies
title_full_unstemmed The role of microglia in the spread of Tau: Relevance for tauopathies
title_sort The role of microglia in the spread of Tau: Relevance for tauopathies
dc.creator.none.fl_str_mv Perea, Juan Ramón
Llorens-Martín, María
Ávila, Jesús
Bolós, Marta
author Perea, Juan Ramón
author_facet Perea, Juan Ramón
Llorens-Martín, María
Ávila, Jesús
Bolós, Marta
author_role author
author2 Llorens-Martín, María
Ávila, Jesús
Bolós, Marta
author2_role author
author
author
dc.contributor.none.fl_str_mv Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España)
Fundación Banco Santander
Fundación Ramón Areces
Alzheimer's Association
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Phagocytosis
Tau protein
Alzheimer’s disease
Tauopathies
Microglia
topic Phagocytosis
Tau protein
Alzheimer’s disease
Tauopathies
Microglia
description Tauopathies are neurodegenerative diseases which course with the accumulation of Tau, mainly in neurons. In addition, Tau accumulates in a hyperphosphorylated and aggregated form. This protein is released into the extracellular space and spreads following a stereotypical pattern, inducing the development of the disease through connected regions of the brain. Microglia—the macrophages of the brain—are involved in maintaining brain homeostasis. They perform a variety of functions related to the surveillance and clearance of pathological proteins, among other dead cells and debris, from the extracellular space that could compromise brain equilibrium. This review focuses on the role played by microglia in tauopathies, specifically in Alzheimer’s disease (AD), and how the uncoupling of activation/phagocytosis functions can have fatal consequences leading to the development of the pathology.
publishDate 2018
dc.date.none.fl_str_mv 2018
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/182406
url http://hdl.handle.net/10261/182406
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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