Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

Ousdal, OT; Argyelan, M; Narr, KL; Abbott, C; Wade, B; Vandenbulcke, M; Urretavizcaya, M; Tendolkar, I; Takamiya, A; Stek, ML; Soriano-Mas, C; Redlich, R; Paulson, OB; Oudega, ML; Opel, N; Nordanskog, P; Kishimoto, T; Kampe, R; Jorgensen, A; Hanson, LG; Hamilton, JP; Espinoza, R; Emsell, L; van Eijndhoven, P; Dols, A; Dannlowski, U; Cardoner, N; Bouckaert, F; Anand, A; Bartsch, H; Kessler, U; Oedegaard, KJ; Dale, AM; Oltedal, L; Erchinger, VJ; Haavik, J; Sorhaug, OJE; Jorgensen, MB; Bolwig, TG; Magnusson, P; Cano, M; Pujol, J; Menchon, JM; Petrides, G; Sienaert, P

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray...

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Authors:	Ousdal, OT, Argyelan, M, Narr, KL, Abbott, C, Wade, B, Vandenbulcke, M, Urretavizcaya, M, Tendolkar, I, Takamiya, A, Stek, ML, Soriano-Mas, C, Redlich, R, Paulson, OB, Oudega, ML, Opel, N, Nordanskog, P, Kishimoto, T, Kampe, R, Jorgensen, A, Hanson, LG, Hamilton, JP, Espinoza, R, Emsell, L, van Eijndhoven, P, Dols, A, Dannlowski, U, Cardoner, N, Bouckaert, F, Anand, A, Bartsch, H, Kessler, U, Oedegaard, KJ, Dale, AM, Oltedal, L, Erchinger, VJ, Haavik, J, Sorhaug, OJE, Jorgensen, MB, Bolwig, TG, Magnusson, P, Cano, M, Pujol, J, Menchon, JM, Petrides, G, Sienaert, P
Format:	article
Status:	Published version
Publication Date:	2020
Country:	España
Institution:	Institut d'Investigació i Innovació Parc Taulí (I3PT)
Repository:	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
OAI Identifier:	oai:i3pt.fundanetsuite.com:p2707
Online Access:	https://i3pt.portalinvestigacion.com/publicaciones/2707
Access Level:	Open access
Keyword:	Antidepressant Biomarker Brain Depression ECT Magnetic resonance imaging Neuroimaging

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spelling	Brain Changes Induced by Electroconvulsive Therapy Are Broadly DistributedOusdal, OTArgyelan, MNarr, KLAbbott, CWade, BVandenbulcke, MUrretavizcaya, MTendolkar, ITakamiya, AStek, MLSoriano-Mas, CRedlich, RPaulson, OBOudega, MLOpel, NNordanskog, PKishimoto, TKampe, RJorgensen, AHanson, LGHamilton, JPEspinoza, REmsell, Lvan Eijndhoven, PDols, ADannlowski, UCardoner, NBouckaert, FAnand, ABartsch, HKessler, UOedegaard, KJDale, AMOltedal, LErchinger, VJHaavik, JSorhaug, OJEJorgensen, MBBolwig, TGMagnusson, PCano, MPujol, JMenchon, JMPetrides, GSienaert, PAntidepressantBiomarkerBrainDepressionECTMagnetic resonance imagingNeuroimagingBACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation rho = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.ELSEVIER SCIENCE INC2020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://i3pt.portalinvestigacion.com/publicaciones/2707Biological PsychiatryISSN: 00063223ISSNe: 18732402reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulíinstname:Institut d'Investigació i Innovació Parc Taulí (I3PT)Inglésinfo:eu-repo/semantics/openAccessoai:i3pt.fundanetsuite.com:p27072026-06-21T15:30:37Z
dc.title.none.fl_str_mv	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
spellingShingle	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed Ousdal, OT Antidepressant Biomarker Brain Depression ECT Magnetic resonance imaging Neuroimaging
title_short	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_full	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_fullStr	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_full_unstemmed	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
title_sort	Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed
dc.creator.none.fl_str_mv	Ousdal, OT Argyelan, M Narr, KL Abbott, C Wade, B Vandenbulcke, M Urretavizcaya, M Tendolkar, I Takamiya, A Stek, ML Soriano-Mas, C Redlich, R Paulson, OB Oudega, ML Opel, N Nordanskog, P Kishimoto, T Kampe, R Jorgensen, A Hanson, LG Hamilton, JP Espinoza, R Emsell, L van Eijndhoven, P Dols, A Dannlowski, U Cardoner, N Bouckaert, F Anand, A Bartsch, H Kessler, U Oedegaard, KJ Dale, AM Oltedal, L Erchinger, VJ Haavik, J Sorhaug, OJE Jorgensen, MB Bolwig, TG Magnusson, P Cano, M Pujol, J Menchon, JM Petrides, G Sienaert, P
author	Ousdal, OT
author_facet	Ousdal, OT Argyelan, M Narr, KL Abbott, C Wade, B Vandenbulcke, M Urretavizcaya, M Tendolkar, I Takamiya, A Stek, ML Soriano-Mas, C Redlich, R Paulson, OB Oudega, ML Opel, N Nordanskog, P Kishimoto, T Kampe, R Jorgensen, A Hanson, LG Hamilton, JP Espinoza, R Emsell, L van Eijndhoven, P Dols, A Dannlowski, U Cardoner, N Bouckaert, F Anand, A Bartsch, H Kessler, U Oedegaard, KJ Dale, AM Oltedal, L Erchinger, VJ Haavik, J Sorhaug, OJE Jorgensen, MB Bolwig, TG Magnusson, P Cano, M Pujol, J Menchon, JM Petrides, G Sienaert, P
author_role	author
author2	Argyelan, M Narr, KL Abbott, C Wade, B Vandenbulcke, M Urretavizcaya, M Tendolkar, I Takamiya, A Stek, ML Soriano-Mas, C Redlich, R Paulson, OB Oudega, ML Opel, N Nordanskog, P Kishimoto, T Kampe, R Jorgensen, A Hanson, LG Hamilton, JP Espinoza, R Emsell, L van Eijndhoven, P Dols, A Dannlowski, U Cardoner, N Bouckaert, F Anand, A Bartsch, H Kessler, U Oedegaard, KJ Dale, AM Oltedal, L Erchinger, VJ Haavik, J Sorhaug, OJE Jorgensen, MB Bolwig, TG Magnusson, P Cano, M Pujol, J Menchon, JM Petrides, G Sienaert, P
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Antidepressant Biomarker Brain Depression ECT Magnetic resonance imaging Neuroimaging
topic	Antidepressant Biomarker Brain Depression ECT Magnetic resonance imaging Neuroimaging
description	BACKGROUND: Electroconvulsive therapy (ECT) is associated with volumetric enlargements of corticolimbic brain regions. However, the pattern of whole-brain structural alterations following ECT remains unresolved. Here, we examined the longitudinal effects of ECT on global and local variations in gray matter, white matter, and ventricle volumes in patients with major depressive disorder as well as predictors of ECT-related clinical response. METHODS: Longitudinal magnetic resonance imaging and clinical data from the Global ECT-MRI Research Collaboration (GEMRIC) were used to investigate changes in white matter, gray matter, and ventricle volumes before and after ECT in 328 patients experiencing a major depressive episode. In addition, 95 nondepressed control subjects were scanned twice. We performed a mega-analysis of single subject data from 14 independent GEMRIC sites. RESULTS: Volumetric increases occurred in 79 of 84 gray matter regions of interest. In total, the cortical volume increased by mean +/- SD of 1.04 +/- 1.03% (Cohen's d = 1.01, p < .001) and the subcortical gray matter volume increased by 1.47 +/- 1.05% (d = 1.40, p < .001) in patients. The subcortical gray matter increase was negatively associated with total ventricle volume (Spearman's rank correlation rho = -.44, p < .001), while total white matter volume remained unchanged (d = -0.05, p = .41). The changes were modulated by number of ECTs and mode of electrode placements. However, the gray matter volumetric enlargements were not associated with clinical outcome. CONCLUSIONS: The findings suggest that ECT induces gray matter volumetric increases that are broadly distributed. However, gross volumetric increases of specific anatomically defined regions may not serve as feasible biomarkers of clinical response.
publishDate	2020
dc.date.none.fl_str_mv	2020
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://i3pt.portalinvestigacion.com/publicaciones/2707
url	https://i3pt.portalinvestigacion.com/publicaciones/2707
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
publisher.none.fl_str_mv	ELSEVIER SCIENCE INC
dc.source.none.fl_str_mv	Biological Psychiatry ISSN: 00063223 ISSNe: 18732402 reponame:r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí instname:Institut d'Investigació i Innovació Parc Taulí (I3PT)
instname_str	Institut d'Investigació i Innovació Parc Taulí (I3PT)
reponame_str	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
collection	r-I3PT. Repositorio Institucional Producción Científica del Institut d'Investigació i Innovació Parc Taulí
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Brain Changes Induced by Electroconvulsive Therapy Are Broadly Distributed

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