Changes in lipoprotein lipase modulate tissular energy supply during stress

We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat. Stress was produced by body immobilization (Immo): the rat's limbs were taped to metal mounts, and its head was placed in a plastic tube. Chronic stres...

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Detalles Bibliográficos
Autores: Ricart i Jané, David, Cejudo Martín, María del Pilar, Peinado Onsurbe, Julia, López Tejero, M. Dolores, Llobera i Sande, Miquel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2005
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/51445
Acceso en línea:https://hdl.handle.net/2445/51445
Access Level:acceso abierto
Palabra clave:Lipoproteïnes
Lipases
Teixit adipós
Rates (Animals de laboratori)
Efecte de l'estrès sobre els animals
Lipoproteins
Lipase
Adipose tissues
Rats as laboratory animals
Effect of stress on animals
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spelling Changes in lipoprotein lipase modulate tissular energy supply during stressRicart i Jané, DavidCejudo Martín, María del PilarPeinado Onsurbe, JuliaLópez Tejero, M. DoloresLlobera i Sande, MiquelLipoproteïnesLipasesTeixit adipósRates (Animals de laboratori)Efecte de l'estrès sobre els animalsLipoproteinsLipaseAdipose tissuesRats as laboratory animalsEffect of stress on animalsWe studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat. Stress was produced by body immobilization (Immo): the rat's limbs were taped to metal mounts, and its head was placed in a plastic tube. Chronic stress (2 h daily of Immo) decreased total LPL activity in mesenteric and epididymal white adipose tissue (WAT) and was accompanied by a weight reduction of these tissues. In limb muscle, heart, and adrenals, total LPL activity and mRNA levels increased, and, in plasma, LPL activity and mass also increased. Acute stress (30-min Immo) caused a decrease in total LPL activity only in retroperitoneal WAT and an increase in preheparin plasma active LPL, but the overall weight of this tissue did not vary significantly. We propose an early release of the enzyme from this tissue into the bloodstream by some unknown extracellular pathways or other local mechanisms. These changes in this key energy-regulating enzyme are probably induced by catecholamines. They modify the flow of energy substrates between tissues, switching the WAT from importer to exporter of free fatty acids and favoring the uptake by muscle of circulating triacylglycerides for energy supply. Moreover, we found that acute stress almost doubled blood flow in all WAT studied, favoring the export of free fatty acids.American Physiological Society2014201420052014info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion10 p.application/pdfhttps://hdl.handle.net/2445/51445Articles publicats en revistes (Bioquímica i Biomedicina Molecular)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: http://dx.doi.org/10.1152/japplphysiol.00971.2004Journal of Applied Physiology, 2005, num.http://dx.doi.org/10.1152/japplphysiol.00971.2004(c) American Physiological Society, 2005info:eu-repo/semantics/openAccessoai:recercat.cat:2445/514452026-05-29T05:05:01Z
dc.title.none.fl_str_mv Changes in lipoprotein lipase modulate tissular energy supply during stress
title Changes in lipoprotein lipase modulate tissular energy supply during stress
spellingShingle Changes in lipoprotein lipase modulate tissular energy supply during stress
Ricart i Jané, David
Lipoproteïnes
Lipases
Teixit adipós
Rates (Animals de laboratori)
Efecte de l'estrès sobre els animals
Lipoproteins
Lipase
Adipose tissues
Rats as laboratory animals
Effect of stress on animals
title_short Changes in lipoprotein lipase modulate tissular energy supply during stress
title_full Changes in lipoprotein lipase modulate tissular energy supply during stress
title_fullStr Changes in lipoprotein lipase modulate tissular energy supply during stress
title_full_unstemmed Changes in lipoprotein lipase modulate tissular energy supply during stress
title_sort Changes in lipoprotein lipase modulate tissular energy supply during stress
dc.creator.none.fl_str_mv Ricart i Jané, David
Cejudo Martín, María del Pilar
Peinado Onsurbe, Julia
López Tejero, M. Dolores
Llobera i Sande, Miquel
author Ricart i Jané, David
author_facet Ricart i Jané, David
Cejudo Martín, María del Pilar
Peinado Onsurbe, Julia
López Tejero, M. Dolores
Llobera i Sande, Miquel
author_role author
author2 Cejudo Martín, María del Pilar
Peinado Onsurbe, Julia
López Tejero, M. Dolores
Llobera i Sande, Miquel
author2_role author
author
author
author
dc.subject.none.fl_str_mv Lipoproteïnes
Lipases
Teixit adipós
Rates (Animals de laboratori)
Efecte de l'estrès sobre els animals
Lipoproteins
Lipase
Adipose tissues
Rats as laboratory animals
Effect of stress on animals
topic Lipoproteïnes
Lipases
Teixit adipós
Rates (Animals de laboratori)
Efecte de l'estrès sobre els animals
Lipoproteins
Lipase
Adipose tissues
Rats as laboratory animals
Effect of stress on animals
description We studied the variations caused by stress in lipoprotein lipase (LPL) activity, LPL-mRNA, and local blood flow in LPL-rich tissues in the rat. Stress was produced by body immobilization (Immo): the rat's limbs were taped to metal mounts, and its head was placed in a plastic tube. Chronic stress (2 h daily of Immo) decreased total LPL activity in mesenteric and epididymal white adipose tissue (WAT) and was accompanied by a weight reduction of these tissues. In limb muscle, heart, and adrenals, total LPL activity and mRNA levels increased, and, in plasma, LPL activity and mass also increased. Acute stress (30-min Immo) caused a decrease in total LPL activity only in retroperitoneal WAT and an increase in preheparin plasma active LPL, but the overall weight of this tissue did not vary significantly. We propose an early release of the enzyme from this tissue into the bloodstream by some unknown extracellular pathways or other local mechanisms. These changes in this key energy-regulating enzyme are probably induced by catecholamines. They modify the flow of energy substrates between tissues, switching the WAT from importer to exporter of free fatty acids and favoring the uptake by muscle of circulating triacylglycerides for energy supply. Moreover, we found that acute stress almost doubled blood flow in all WAT studied, favoring the export of free fatty acids.
publishDate 2005
dc.date.none.fl_str_mv 2005
2014
2014
2014
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/51445
url https://hdl.handle.net/2445/51445
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1152/japplphysiol.00971.2004
Journal of Applied Physiology, 2005, num.
http://dx.doi.org/10.1152/japplphysiol.00971.2004
dc.rights.none.fl_str_mv (c) American Physiological Society, 2005
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) American Physiological Society, 2005
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 10 p.
application/pdf
dc.publisher.none.fl_str_mv American Physiological Society
publisher.none.fl_str_mv American Physiological Society
dc.source.none.fl_str_mv Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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