Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients

Background Artemisinins (ART) are the key component of the frontline antimalarial treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural malaria infections remains unknown. This is an important knowledge gap because sexual conversion rates determine the relative para...

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Autores: Portugaliza HP, Natama HM, Guetens P, Rovira-Vallbona E, Somé AM, Millogo A, Ouédraogo DF, Valéa I, Sorgho H, Tinto H, van Hong N, Sitoe A, Varo R, Bassat Q, Cortés A, Rosanas-Urgell A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p21948
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21948
Access Level:acceso abierto
Palabra clave:Plasmodium falciparum
Sexual conversion
Artemisinin
Malaria transmission
pfap2-g
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spelling Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patientsPortugaliza HPNatama HMGuetens PRovira-Vallbona ESomé AMMillogo AOuédraogo DFValéa ISorgho HTinto Hvan Hong NSitoe AVaro RBassat QCortés ARosanas-Urgell APlasmodium falciparumSexual conversionArtemisininMalaria transmissionpfap2-gBackground Artemisinins (ART) are the key component of the frontline antimalarial treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural malaria infections remains unknown. This is an important knowledge gap because sexual conversion rates determine the relative parasite investment between maintaining infection in the same human host and transmission to mosquitoes.Methods The primary outcome of this study was to assess the impact of ART-based treatment on sexual conversion rates by comparing the relative transcript levels of pfap2-g and other sexual ring biomarkers (SRBs) before and after treatment. We analysed samples from previously existing cohorts in Vietnam, Burkina Faso and Mozambique (in total, n=109) collected before treatment and at 12 h intervals after treatment. As a secondary objective, we investi-gated factors that may influence the effect of treatment on sexual conversion rates.Findings In the majority of infections from the African cohorts, but not from Vietnam, we observed increased expression of pfap2-g and other SRBs after treatment. Estimated parasite age at the time of treatment was negatively correlated with the increase in pfap2-g transcript levels, suggesting that younger parasites are less susceptible to stim-ulation of sexual conversion.Interpretation We observed enhanced expression of SRBs after ART-based treatment in many patients, which sug-gests that in natural malaria infections sexual conversion rates can be altered by treatment. ART-based treatment reduces the potential of a treated individual to transmit the disease, but we hypothesise that under some circumstan-ces this reduction may be attenuated by ART-enhanced sexual conversion.Funding Spanish Agencia Estatal de Investigaci?on (AEI), European Regional Development Fund (ERDF, European Union), Belgium Development Cooperation (DGD), Canadian University Health Network (UHN), TransGlobal-Health-Erasmus Mundus (European Union).Copyright (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) eBioMedicine 104198 Published online https://doi.org/10.1016/j. ebiom.2022.104198ELSEVIER2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21948EBioMedicineISSN: 23523964reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p219482026-05-27T12:37:41Z
dc.title.none.fl_str_mv Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
title Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
spellingShingle Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
Portugaliza HP
Plasmodium falciparum
Sexual conversion
Artemisinin
Malaria transmission
pfap2-g
title_short Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
title_full Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
title_fullStr Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
title_full_unstemmed Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
title_sort Plasmodium falciparum sexual conversion rates can be affected by artemisinin-based treatment in naturally infected malaria patients
dc.creator.none.fl_str_mv Portugaliza HP
Natama HM
Guetens P
Rovira-Vallbona E
Somé AM
Millogo A
Ouédraogo DF
Valéa I
Sorgho H
Tinto H
van Hong N
Sitoe A
Varo R
Bassat Q
Cortés A
Rosanas-Urgell A
author Portugaliza HP
author_facet Portugaliza HP
Natama HM
Guetens P
Rovira-Vallbona E
Somé AM
Millogo A
Ouédraogo DF
Valéa I
Sorgho H
Tinto H
van Hong N
Sitoe A
Varo R
Bassat Q
Cortés A
Rosanas-Urgell A
author_role author
author2 Natama HM
Guetens P
Rovira-Vallbona E
Somé AM
Millogo A
Ouédraogo DF
Valéa I
Sorgho H
Tinto H
van Hong N
Sitoe A
Varo R
Bassat Q
Cortés A
Rosanas-Urgell A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Plasmodium falciparum
Sexual conversion
Artemisinin
Malaria transmission
pfap2-g
topic Plasmodium falciparum
Sexual conversion
Artemisinin
Malaria transmission
pfap2-g
description Background Artemisinins (ART) are the key component of the frontline antimalarial treatment, but their impact on Plasmodium falciparum sexual conversion rates in natural malaria infections remains unknown. This is an important knowledge gap because sexual conversion rates determine the relative parasite investment between maintaining infection in the same human host and transmission to mosquitoes.Methods The primary outcome of this study was to assess the impact of ART-based treatment on sexual conversion rates by comparing the relative transcript levels of pfap2-g and other sexual ring biomarkers (SRBs) before and after treatment. We analysed samples from previously existing cohorts in Vietnam, Burkina Faso and Mozambique (in total, n=109) collected before treatment and at 12 h intervals after treatment. As a secondary objective, we investi-gated factors that may influence the effect of treatment on sexual conversion rates.Findings In the majority of infections from the African cohorts, but not from Vietnam, we observed increased expression of pfap2-g and other SRBs after treatment. Estimated parasite age at the time of treatment was negatively correlated with the increase in pfap2-g transcript levels, suggesting that younger parasites are less susceptible to stim-ulation of sexual conversion.Interpretation We observed enhanced expression of SRBs after ART-based treatment in many patients, which sug-gests that in natural malaria infections sexual conversion rates can be altered by treatment. ART-based treatment reduces the potential of a treated individual to transmit the disease, but we hypothesise that under some circumstan-ces this reduction may be attenuated by ART-enhanced sexual conversion.Funding Spanish Agencia Estatal de Investigaci?on (AEI), European Regional Development Fund (ERDF, European Union), Belgium Development Cooperation (DGD), Canadian University Health Network (UHN), TransGlobal-Health-Erasmus Mundus (European Union).Copyright (c) 2022 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) eBioMedicine 104198 Published online https://doi.org/10.1016/j. ebiom.2022.104198
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21948
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=21948
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER
publisher.none.fl_str_mv ELSEVIER
dc.source.none.fl_str_mv EBioMedicine
ISSN: 23523964
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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