Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs

Fatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its associa...

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Autores: Hernández Banqué, Carles, Liu, Junhui, Jové Juncà, Teodor, González Rodríguez, Olga, Portero Otín, Manuel, Folch, Josep Maria, Quintanilla, Raquel, Ballester, Maria
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/469554
Acceso en línea:https://doi.org/10.1038/s41598-025-27713-3
https://hdl.handle.net/10459.1/469554
http://hdl.handle.net/10459.1/469554
Access Level:acceso abierto
Palabra clave:Fatty acid profiles
Genetic correlations
Heritability
Immunity
Pig
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spelling Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigsHernández Banqué, CarlesLiu, JunhuiJové Juncà, TeodorGonzález Rodríguez, OlgaPortero Otín, ManuelFolch, Josep MariaQuintanilla, RaquelBallester, MariaFatty acid profilesGenetic correlationsHeritabilityImmunityPigFatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its association with immunocompetence and performance traits in pigs. Fatty acid profiles were analysed in 432 commercial Duroc pigs. High heritability was found for most fatty acids in backfat and for long-chain polyunsaturated fatty acids in liver, while muscle and plasma showed medium to low heritabilities. Strong genetic correlations were observed between the relative abundance of γδ T cells and cytotoxic T cells with the lipid profiles of backfat and muscle, with opposite patterns between these cell types. Muscle unsaturated fatty acids were positively correlated with phagocytosis capacity and red blood cell traits, and negatively with plasma cortisol. Acute phase proteins showed similar correlations with liver lipids but opposite with some plasma fatty acids. Lean meat and fatness traits were particularly associated to the backfat fatty acid composition, showing opposite correlation patterns, while pH was strongly correlated with the liver fatty acid profile. These results demonstrated the specific lipid profiles of backfat, liver, muscle and plasma, their genetic determinism, and their relationships with immunity and production traits.The study was funded by grants PID2020-112677RB-C21 and PID2023-148961OB-C21 and awarded by MCIN/AEI/https://doi.org/10.13039/501100011033. C. Hernández-Banqué was supported by a FPI grant (PRE2021-097825) granted by the Spanish Ministry of Science and Innovation. T. Jové-Juncà was funded with an IRTA fellowship (CPI1221). The authors are part to a Consolidated Research Group AGAUR “Sustainable animal husbandry” (AGAUR, reference 2021-SGR-01552).Springer Nature2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1038/s41598-025-27713-3https://hdl.handle.net/10459.1/469554http://hdl.handle.net/10459.1/469554reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1038/s41598-025-27713-3Scientific Reports, 2025, vol. 15, 43982cc-by-nc-nd, (c) Carles Hernández Banqué et al., 2025Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:recercat.cat:10459.1/4695542026-05-29T05:05:01Z
dc.title.none.fl_str_mv Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
spellingShingle Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
Hernández Banqué, Carles
Fatty acid profiles
Genetic correlations
Heritability
Immunity
Pig
title_short Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_full Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_fullStr Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_full_unstemmed Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
title_sort Genetic determinism of fatty acid composition in liver, muscle, backfat and plasma and its link to immunocompetence and performance in pigs
dc.creator.none.fl_str_mv Hernández Banqué, Carles
Liu, Junhui
Jové Juncà, Teodor
González Rodríguez, Olga
Portero Otín, Manuel
Folch, Josep Maria
Quintanilla, Raquel
Ballester, Maria
author Hernández Banqué, Carles
author_facet Hernández Banqué, Carles
Liu, Junhui
Jové Juncà, Teodor
González Rodríguez, Olga
Portero Otín, Manuel
Folch, Josep Maria
Quintanilla, Raquel
Ballester, Maria
author_role author
author2 Liu, Junhui
Jové Juncà, Teodor
González Rodríguez, Olga
Portero Otín, Manuel
Folch, Josep Maria
Quintanilla, Raquel
Ballester, Maria
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fatty acid profiles
Genetic correlations
Heritability
Immunity
Pig
topic Fatty acid profiles
Genetic correlations
Heritability
Immunity
Pig
description Fatty acids are a diverse group of lipid molecules that play essential roles in energy metabolism, cellular differentiation and signalling mechanisms. The objective of this study was to explore the genetic determinism of fatty acid composition across backfat, liver, muscle and plasma and its association with immunocompetence and performance traits in pigs. Fatty acid profiles were analysed in 432 commercial Duroc pigs. High heritability was found for most fatty acids in backfat and for long-chain polyunsaturated fatty acids in liver, while muscle and plasma showed medium to low heritabilities. Strong genetic correlations were observed between the relative abundance of γδ T cells and cytotoxic T cells with the lipid profiles of backfat and muscle, with opposite patterns between these cell types. Muscle unsaturated fatty acids were positively correlated with phagocytosis capacity and red blood cell traits, and negatively with plasma cortisol. Acute phase proteins showed similar correlations with liver lipids but opposite with some plasma fatty acids. Lean meat and fatness traits were particularly associated to the backfat fatty acid composition, showing opposite correlation patterns, while pH was strongly correlated with the liver fatty acid profile. These results demonstrated the specific lipid profiles of backfat, liver, muscle and plasma, their genetic determinism, and their relationships with immunity and production traits.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41598-025-27713-3
https://hdl.handle.net/10459.1/469554
http://hdl.handle.net/10459.1/469554
url https://doi.org/10.1038/s41598-025-27713-3
https://hdl.handle.net/10459.1/469554
http://hdl.handle.net/10459.1/469554
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a https://doi.org/10.1038/s41598-025-27713-3
Scientific Reports, 2025, vol. 15, 43982
dc.rights.none.fl_str_mv cc-by-nc-nd, (c) Carles Hernández Banqué et al., 2025
Attribution-NonCommercial-NoDerivatives 4.0 International
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
rights_invalid_str_mv cc-by-nc-nd, (c) Carles Hernández Banqué et al., 2025
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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