Real-world evaluation of a QCM-based biosensor for exhaled air

The biosensor, named "virusmeter" in this study, integrates quartz crystal microbalance technology with an immune-functionalized chip to distinguish between symptomatic patients with respiratory diseases and healthy individuals by analyzing exhaled air samples. Renowned for its compact des...

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Detalles Bibliográficos
Autores: Juste-Dolz, A, Teixeira, W, Pallás-Tamarit, Y, Carballido-Fernández, M, Carrascosa, J, Morán-Porcar, A, Redón-Badenas, MA, Pla-Roses, MG, Tirado-Balaguer, MD, Remolar-Quintana, MJ, Ortiz-Carrera, J, Ibañez-Echevarría, E, Maquieira, A, Giménez-Romero, D
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17457
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/17457
Access Level:acceso abierto
Palabra clave:Virusmeter
Breathalyzer
QCM
Diagnosis
Descripción
Sumario:The biosensor, named "virusmeter" in this study, integrates quartz crystal microbalance technology with an immune-functionalized chip to distinguish between symptomatic patients with respiratory diseases and healthy individuals by analyzing exhaled air samples. Renowned for its compact design, rapidity, and noninvasive nature, this device yields results within a 5-min timeframe. Evaluated under controlled conditions with 54 hospitalized symptomatic COVID-19 patients and 128 control subjects, the biosensor demonstrated good overall sensitivity (98.15%, 95% CI 90.1-100.0) and specificity (96.87%, 95% CI 92.2-99.1). This proof-of-concept presents an innovative approach with significant potential for leveraging piezoelectric sensors to diagnose respiratory diseases.

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