Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation

Excessive bone resorption is one of the main causes of bone homeostasis alterations, resulting in an imbalance in the natural remodeling cycle. This imbalance can cause diseases such as osteoporosis, or it can be exacerbated in bone cancer processes. In such cases, there is an increased risk of frac...

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Autores: Piñera-Avellaneda D, Buxadera-Palomero J, Ginebra MP, Rupérez E, Manero JM
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p25190
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25190
Access Level:acceso abierto
Palabra clave:titanium implant
gallium
osteoclast
osteoporosis
bone metastasis
ferroptosis
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spelling Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiationPiñera-Avellaneda DBuxadera-Palomero JGinebra MPRupérez EManero JMtitanium implantgalliumosteoclastosteoporosisbone metastasisferroptosisExcessive bone resorption is one of the main causes of bone homeostasis alterations, resulting in an imbalance in the natural remodeling cycle. This imbalance can cause diseases such as osteoporosis, or it can be exacerbated in bone cancer processes. In such cases, there is an increased risk of fractures requiring a prosthesis. In the present study, a titanium implant subjected to gallium (Ga)-doped thermochemical treatment was evaluated as a strategy to reduce bone resorption and improve osteodifferentiation. The suitability of the material to reduce bone resorption was proven by inducing macrophages (RAW 264.7) to differentiate to osteoclasts on Ga-containing surfaces. In addition, the behavior of human mesenchymal stem cells (hMSCs) was studied in terms of cell adhesion, morphology, proliferation, and differentiation. The results proved that the Ga-containing calcium titanate layer is capable of inhibiting osteoclastogenesis, hypothetically by inducing ferroptosis. Furthermore, Ga-containing surfaces promote the differentiation of hMSCs into osteoblasts. Therefore, Ga-containing calcium titanate may be a promising strategy for patients with fractures resulting from an excessive bone resorption disease.FRONTIERS MEDIA SA2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25190Frontiers in Bioengineering and BiotechnologyISSN: 22964185reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p251902026-05-27T12:37:41Z
dc.title.none.fl_str_mv Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
title Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
spellingShingle Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
Piñera-Avellaneda D
titanium implant
gallium
osteoclast
osteoporosis
bone metastasis
ferroptosis
title_short Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
title_full Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
title_fullStr Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
title_full_unstemmed Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
title_sort Gallium-doped thermochemically treated titanium reduces osteoclastogenesis and improves osteodifferentiation
dc.creator.none.fl_str_mv Piñera-Avellaneda D
Buxadera-Palomero J
Ginebra MP
Rupérez E
Manero JM
author Piñera-Avellaneda D
author_facet Piñera-Avellaneda D
Buxadera-Palomero J
Ginebra MP
Rupérez E
Manero JM
author_role author
author2 Buxadera-Palomero J
Ginebra MP
Rupérez E
Manero JM
author2_role author
author
author
author
dc.subject.none.fl_str_mv titanium implant
gallium
osteoclast
osteoporosis
bone metastasis
ferroptosis
topic titanium implant
gallium
osteoclast
osteoporosis
bone metastasis
ferroptosis
description Excessive bone resorption is one of the main causes of bone homeostasis alterations, resulting in an imbalance in the natural remodeling cycle. This imbalance can cause diseases such as osteoporosis, or it can be exacerbated in bone cancer processes. In such cases, there is an increased risk of fractures requiring a prosthesis. In the present study, a titanium implant subjected to gallium (Ga)-doped thermochemical treatment was evaluated as a strategy to reduce bone resorption and improve osteodifferentiation. The suitability of the material to reduce bone resorption was proven by inducing macrophages (RAW 264.7) to differentiate to osteoclasts on Ga-containing surfaces. In addition, the behavior of human mesenchymal stem cells (hMSCs) was studied in terms of cell adhesion, morphology, proliferation, and differentiation. The results proved that the Ga-containing calcium titanate layer is capable of inhibiting osteoclastogenesis, hypothetically by inducing ferroptosis. Furthermore, Ga-containing surfaces promote the differentiation of hMSCs into osteoblasts. Therefore, Ga-containing calcium titanate may be a promising strategy for patients with fractures resulting from an excessive bone resorption disease.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25190
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=25190
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Bioengineering and Biotechnology
ISSN: 22964185
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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