Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin

[eng] INTRODUCTION: The introduction of new drugs such as sacubitril/valsartan and empagliflozin has markedly improved clinical outcomes in patients with heart failure (HF). The role of these drugs in HF is well-established; however, their efficacy on post-acute myocardial infarction (AMI) remains l...

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Autor: Martínez Falguera, Daina
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/221664
Acceso en línea:https://hdl.handle.net/2445/221664
http://hdl.handle.net/10803/694698
Access Level:acceso abierto
Palabra clave:Cardiologia
Malalties cardiovasculars
Anàlisi de medicaments
Inflamació
Arrítmia
Cardiology
Cardiovascular diseases
Drugs analysis
Inflammation
Arrhythmia
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spelling Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozinMartínez Falguera, DainaCardiologiaMalalties cardiovascularsAnàlisi de medicamentsInflamacióArrítmiaCardiologyCardiovascular diseasesDrugs analysisInflammationArrhythmia[eng] INTRODUCTION: The introduction of new drugs such as sacubitril/valsartan and empagliflozin has markedly improved clinical outcomes in patients with heart failure (HF). The role of these drugs in HF is well-established; however, their efficacy on post-acute myocardial infarction (AMI) remains largely unexplored. Limited evidence exists on the safety and the potential synergistic effects when combining empagliflozin with sacubitril/valsartan post-AMI. HYPOTHESIS: The early administration of empagliflozin and/or sacubitril/valsartan after MI may exert a protective role against post-ischemic injury by reducing inflammation and oxidative stress, enhancing cardiac metabolism, and/or providing protective effects on post-AMI structural and electrical remodelling. The combination of both drugs could be safe and may have a synergistic effect. OBJECTIVES: To evaluate the cardiac impact of early initiation of empagliflozin and/or sacubitril/valsartan on inflammation, oxidative stress, metabolism, myocardial fibrosis, cardiac function, electrophysiological and histological scar properties, and ventricular tachycardia (VT) inducibility in an AMI pig model.[spa] INTRODUCCIÓ: La introducció de nous fàrmacs com el sacubitril/valsartan i l’empagliflozina ha millorat significativament els resultats clínics en pacients amb insuficiència cardíaca (IC). El seu paper en la IC està ben establert; no obstant, la seva eficiència després d’un infart agut de miocardi (IAM) roman en gran mesura inexplorada. Existeix poca evidència sobre la seguretat i els possibles efectes sinèrgics quan es combinen aquests dos fàrmacs després d’un IAM. HIPÒTESI: L’administració primerenca d’empagliflozina i/o sacubitril/valsartan després d’un IAM pot exercir un paper protector contra la lesió post-isquèmica mitjançant la reducció de la inflamació i l’estrès oxidatiu, la millora del metabolisme cardíac i/o la provisió d’efectes protectors sobre el remodelat estructural i elèctric cardíac. La combinació d’ambdós fàrmacs podria ser segura i exercir un efecte sinèrgic. OBJECTIUS: Avaluar l’impacte de la iniciació primerenca de l’empagliflozina i/o el sacubitril/valsartan sobre la inflamació, l’estrès oxidatiu, el metabolisme, la fibrosi, la funció cardíaca, les propietats electrofisiològiques i histològiques de la cicatriu, i la inducibilitat de taquicàrdia ventricular (TV) en un model porcí d’IAM.Universitat de BarcelonaBayés Genís, AntoniGàlvez Montón, CarolinaUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut2025info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/221664http://hdl.handle.net/10803/694698Tesis Doctorals - Facultat - Medicina i Ciències de la Salutreponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglés(c) Martínez Falguera, Daina, 2025info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2216642026-05-27T06:46:51Z
dc.title.none.fl_str_mv Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
title Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
spellingShingle Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
Martínez Falguera, Daina
Cardiologia
Malalties cardiovasculars
Anàlisi de medicaments
Inflamació
Arrítmia
Cardiology
Cardiovascular diseases
Drugs analysis
Inflammation
Arrhythmia
title_short Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
title_full Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
title_fullStr Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
title_full_unstemmed Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
title_sort Impact of new pharmacological strategies for the treatment of acute myocardial infarction: study of the effects and synergy of sacubitril/valsartan and empagliflozin
dc.creator.none.fl_str_mv Martínez Falguera, Daina
author Martínez Falguera, Daina
author_facet Martínez Falguera, Daina
author_role author
dc.contributor.none.fl_str_mv Bayés Genís, Antoni
Gàlvez Montón, Carolina
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Cardiologia
Malalties cardiovasculars
Anàlisi de medicaments
Inflamació
Arrítmia
Cardiology
Cardiovascular diseases
Drugs analysis
Inflammation
Arrhythmia
topic Cardiologia
Malalties cardiovasculars
Anàlisi de medicaments
Inflamació
Arrítmia
Cardiology
Cardiovascular diseases
Drugs analysis
Inflammation
Arrhythmia
description [eng] INTRODUCTION: The introduction of new drugs such as sacubitril/valsartan and empagliflozin has markedly improved clinical outcomes in patients with heart failure (HF). The role of these drugs in HF is well-established; however, their efficacy on post-acute myocardial infarction (AMI) remains largely unexplored. Limited evidence exists on the safety and the potential synergistic effects when combining empagliflozin with sacubitril/valsartan post-AMI. HYPOTHESIS: The early administration of empagliflozin and/or sacubitril/valsartan after MI may exert a protective role against post-ischemic injury by reducing inflammation and oxidative stress, enhancing cardiac metabolism, and/or providing protective effects on post-AMI structural and electrical remodelling. The combination of both drugs could be safe and may have a synergistic effect. OBJECTIVES: To evaluate the cardiac impact of early initiation of empagliflozin and/or sacubitril/valsartan on inflammation, oxidative stress, metabolism, myocardial fibrosis, cardiac function, electrophysiological and histological scar properties, and ventricular tachycardia (VT) inducibility in an AMI pig model.
publishDate 2025
dc.date.none.fl_str_mv 2025
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/221664
http://hdl.handle.net/10803/694698
url https://hdl.handle.net/2445/221664
http://hdl.handle.net/10803/694698
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv (c) Martínez Falguera, Daina, 2025
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Martínez Falguera, Daina, 2025
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv Tesis Doctorals - Facultat - Medicina i Ciències de la Salut
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420032429129728
score 15,81155

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