Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction

INTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abn...

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Autores: Illa Armengol, Míriam, Brito, Verónica, Pla, Laura, Eixarch Roca, Elisenda, Arbat-Plana, Ariadna, Batallé Bolaño, Dafnis, Muñoz-Moreno, Emma, Crispi Brillas, Fàtima, Udina, Esther, Figueras Retuerta, Francesc, Ginés Padrós, Silvia, Gratacós Solsona, Eduard
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2017
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/134061
Acceso en línea:https://hdl.handle.net/2445/134061
Access Level:acceso abierto
Palabra clave:Models animals en la investigació
Neonatologia
Retard del creixement intrauterí
Animal models in research
Neonatology
Fetal growth retardation
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spelling Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth RestrictionIlla Armengol, MíriamBrito, VerónicaPla, LauraEixarch Roca, ElisendaArbat-Plana, AriadnaBatallé Bolaño, DafnisMuñoz-Moreno, EmmaCrispi Brillas, FàtimaUdina, EstherFigueras Retuerta, FrancescGinés Padrós, SilviaGratacós Solsona, EduardModels animals en la investigacióNeonatologiaRetard del creixement intrauteríAnimal models in researchNeonatologyFetal growth retardationINTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. MATERIALS AND METHODS: IUGR was surgically induced in one horn, whereas the contralateral one produced the controls. Postnatally, a subgroup of IUGR animals was housed in an enriched environment. Functional assessment was performed at the neonatal and long-term periods. At the long-term period, structural brain connectivity was evaluated by means of diffusion-weighted brain magnetic resonance imaging and by histological assessment focused on the hippocampus. RESULTS: IUGR animals displayed poorer functional results and presented altered whole-brain networks and decreased median fractional anisotropy in the hippocampus. Reduced density of dendritic spines and perineuronal nets from hippocampal neurons were also observed. Of note, IUGR animals exposed to enriched environment presented an improvement in terms of both function and structure. CONCLUSIONS: IUGR is associated with altered brain connectivity at the global and cellular level. A strategy based on early EE has the potential to restore the neurodevelopmental consequences of IUGR.Karger2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://hdl.handle.net/2445/134061Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésVersió postprint del document publicat a: https://doi.org/10.1159/000481171Fetal Diagnosis and Therapy, 2017, vol. 44, num. 3, p. 184-193https://doi.org/10.1159/000481171(c) Karger, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1340612026-05-27T06:46:51Z
dc.title.none.fl_str_mv Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
title Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
spellingShingle Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
Illa Armengol, Míriam
Models animals en la investigació
Neonatologia
Retard del creixement intrauterí
Animal models in research
Neonatology
Fetal growth retardation
title_short Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
title_full Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
title_fullStr Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
title_full_unstemmed Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
title_sort Early Environmental Enrichment Enhances Abnormal Brain Connectivity in a Rabbit Model of Intrauterine Growth Restriction
dc.creator.none.fl_str_mv Illa Armengol, Míriam
Brito, Verónica
Pla, Laura
Eixarch Roca, Elisenda
Arbat-Plana, Ariadna
Batallé Bolaño, Dafnis
Muñoz-Moreno, Emma
Crispi Brillas, Fàtima
Udina, Esther
Figueras Retuerta, Francesc
Ginés Padrós, Silvia
Gratacós Solsona, Eduard
author Illa Armengol, Míriam
author_facet Illa Armengol, Míriam
Brito, Verónica
Pla, Laura
Eixarch Roca, Elisenda
Arbat-Plana, Ariadna
Batallé Bolaño, Dafnis
Muñoz-Moreno, Emma
Crispi Brillas, Fàtima
Udina, Esther
Figueras Retuerta, Francesc
Ginés Padrós, Silvia
Gratacós Solsona, Eduard
author_role author
author2 Brito, Verónica
Pla, Laura
Eixarch Roca, Elisenda
Arbat-Plana, Ariadna
Batallé Bolaño, Dafnis
Muñoz-Moreno, Emma
Crispi Brillas, Fàtima
Udina, Esther
Figueras Retuerta, Francesc
Ginés Padrós, Silvia
Gratacós Solsona, Eduard
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Models animals en la investigació
Neonatologia
Retard del creixement intrauterí
Animal models in research
Neonatology
Fetal growth retardation
topic Models animals en la investigació
Neonatologia
Retard del creixement intrauterí
Animal models in research
Neonatology
Fetal growth retardation
description INTRODUCTION: The structural correspondence of neurodevelopmental impairments related to intrauterine growth restriction (IUGR) that persists later in life remains elusive. Moreover, early postnatal stimulation strategies have been proposed to mitigate these effects. Long-term brain connectivity abnormalities in an IUGR rabbit model and the effects of early postnatal environmental enrichment (EE) were explored. MATERIALS AND METHODS: IUGR was surgically induced in one horn, whereas the contralateral one produced the controls. Postnatally, a subgroup of IUGR animals was housed in an enriched environment. Functional assessment was performed at the neonatal and long-term periods. At the long-term period, structural brain connectivity was evaluated by means of diffusion-weighted brain magnetic resonance imaging and by histological assessment focused on the hippocampus. RESULTS: IUGR animals displayed poorer functional results and presented altered whole-brain networks and decreased median fractional anisotropy in the hippocampus. Reduced density of dendritic spines and perineuronal nets from hippocampal neurons were also observed. Of note, IUGR animals exposed to enriched environment presented an improvement in terms of both function and structure. CONCLUSIONS: IUGR is associated with altered brain connectivity at the global and cellular level. A strategy based on early EE has the potential to restore the neurodevelopmental consequences of IUGR.
publishDate 2017
dc.date.none.fl_str_mv 2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134061
url https://hdl.handle.net/2445/134061
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1159/000481171
Fetal Diagnosis and Therapy, 2017, vol. 44, num. 3, p. 184-193
https://doi.org/10.1159/000481171
dc.rights.none.fl_str_mv (c) Karger, 2017
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Karger, 2017
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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