New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy gr...
| Autores: | , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Data de publicação: | 2012 |
| País: | España |
| Recursos: | Universidad de Navarra |
| Repositório: | Dadun. Depósito Académico Digital de la Universidad de Navarra |
| Idioma: | inglês |
| OAI Identifier: | oai:dadun.unav.edu:10171/23603 |
| Acesso em linha: | https://hdl.handle.net/10171/23603 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Sleep disorders Melatonim MT1/MT2 receptors Quinoxalinamide Quinoxalinurea |
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New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands.Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7Castrillo, N. (Nerea)|||/items/36deb206-822c-4368-aaf7-c1e65adc3051Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8Delagrange, P. (Philippe)|||/items/416a6137-f100-4c54-bbbc-c07e4c5af0a1Caignard, D.H. (Daniel-Henry)|||/items/a39b87ab-4199-4ea6-930f-dd23d9193f85Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fdSleep disordersMelatonimMT1/MT2 receptorsQuinoxalinamideQuinoxalinureaEver since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligandsMDPIDadun. Depósito Académico Digital Universidad de Navarra20122012-10-3120122012-01-0120122012-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10171/23603reponame:Dadun. Depósito Académico Digital de la Universidad de Navarrainstname:Universidad de NavarraInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:dadun.unav.edu:10171/236032026-06-21T12:47:57Z |
| dc.title.none.fl_str_mv |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| title |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| spellingShingle |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Sleep disorders Melatonim MT1/MT2 receptors Quinoxalinamide Quinoxalinurea |
| title_short |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| title_full |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| title_fullStr |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| title_full_unstemmed |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| title_sort |
New quinoxaline derivatives as potential MT₁ and MT₂ receptor ligands. |
| dc.creator.none.fl_str_mv |
Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Castrillo, N. (Nerea)|||/items/36deb206-822c-4368-aaf7-c1e65adc3051 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Delagrange, P. (Philippe)|||/items/416a6137-f100-4c54-bbbc-c07e4c5af0a1 Caignard, D.H. (Daniel-Henry)|||/items/a39b87ab-4199-4ea6-930f-dd23d9193f85 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd |
| author |
Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 |
| author_facet |
Ancizu, S. (Saioa)|||/items/b7ddb356-5d8e-4be4-a223-63fbcd1a34e7 Castrillo, N. (Nerea)|||/items/36deb206-822c-4368-aaf7-c1e65adc3051 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Delagrange, P. (Philippe)|||/items/416a6137-f100-4c54-bbbc-c07e4c5af0a1 Caignard, D.H. (Daniel-Henry)|||/items/a39b87ab-4199-4ea6-930f-dd23d9193f85 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd |
| author_role |
author |
| author2 |
Castrillo, N. (Nerea)|||/items/36deb206-822c-4368-aaf7-c1e65adc3051 Pérez-Silanes, S. (Silvia)|||/items/e5734c65-2dd8-4fdd-a74a-fc7526136c45 Aldana, I. (Ignacio)|||/items/2a317afc-d6ab-4970-8bac-41d9715f5618 Monge, A. (Antonio)|||/items/804a350e-c7ff-4318-9742-cdc3432eb2a8 Delagrange, P. (Philippe)|||/items/416a6137-f100-4c54-bbbc-c07e4c5af0a1 Caignard, D.H. (Daniel-Henry)|||/items/a39b87ab-4199-4ea6-930f-dd23d9193f85 Galiano, S. (Silvia)|||/items/10b9d373-6e6e-46e4-bfae-e7b241dad5fd |
| author2_role |
author author author author author author author |
| dc.contributor.none.fl_str_mv |
Dadun. Depósito Académico Digital Universidad de Navarra |
| dc.subject.none.fl_str_mv |
Sleep disorders Melatonim MT1/MT2 receptors Quinoxalinamide Quinoxalinurea |
| topic |
Sleep disorders Melatonim MT1/MT2 receptors Quinoxalinamide Quinoxalinurea |
| description |
Ever since the idea arose that melatonin might promote sleep and resynchronize circadian rhythms, many research groups have centered their efforts on obtaining new melatonin receptor ligands whose pharmacophores include an aliphatic chain of variable length united to an N-alkylamide and a methoxy group (or a bioisostere), linked to a central ring. Substitution of the indole ring found in melatonin with a naphthalene or quinoline ring leads to compounds of similar affinity. The next step in this structural approximation is to introduce a quinoxaline ring (a bioisostere of the quinoline and naphthalene rings) as the central nucleus of future melatoninergic ligands |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012 2012-10-31 2012 2012-01-01 2012 2012-01-01 |
| dc.type.none.fl_str_mv |
journal article http://purl.org/coar/resource_type/c_6501 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/10171/23603 |
| url |
https://hdl.handle.net/10171/23603 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Dadun. Depósito Académico Digital de la Universidad de Navarra instname:Universidad de Navarra |
| instname_str |
Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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Dadun. Depósito Académico Digital de la Universidad de Navarra |
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15,301603 |