Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy co...

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Detalles Bibliográficos
Autores: Serra Blasco, María, Radua, Joaquim, Soriano Mas, Carles, Gómez Benlloch, Alba, Porta Casteràs, Daniel, Carulla, Montserrat, 1930-, Albajes Eizagirre, Anton, Arnone, Danilo, Klauser, Paul, Canales Rodríguez, Erick Jorge, Hilbert, Kevin, Wise, Toby, Cheng, Yuqui, Kandilarova, Sevdalina, Mataix-Cols, David, Vieta i Pascual, Eduard, 1963-, Via Virgili, Esther, Cardoner, N. (Narcís)
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180085
Acceso en línea:https://hdl.handle.net/2445/180085
Access Level:acceso abierto
Palabra clave:Psicopatologia
Comorbiditat
Psychology, Pathological
Comorbidity
Descripción
Sumario:The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress Disorder (PTSD) has hindered the study of their structural neural correlates. The authors analyzed specific and common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). The meta-analysis of voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) and less robust smaller GMV across diagnostics (p < 0.01, uncorrected). Pairwise comparison between the disorders showed GMV differences in MDD versus ANX and in ANX versus PTSD. These results endorse the hypothesis that unique clinical features characterizing MDD, ANX, and PTSD are also reflected by disorder specific GMV correlates.

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