AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation

Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with...

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Autores: Herms Fiol, Albert, Bosch i Rodríguez, Marta, Reddy, Babu J. N., Schieber, Nicole L., Fajardo, Alba, Rupérez, Celia, Fernández-Vidal, Andrea, Rentero Alfonso, Carles, Tebar Ramon, Francesc, Enrich Bastús, Carles, Parton, Robert G., Gross, Steven P., Pol i Sorolla, Albert
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/118508
Acceso en línea:https://hdl.handle.net/2445/118508
Access Level:acceso abierto
Palabra clave:Metabolisme dels lípids
Transport biològic
Mitocondris
Microtúbuls
Lipid metabolism
Biological transport
Mitochondria
Microtubules
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spelling AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidationHerms Fiol, AlbertBosch i Rodríguez, MartaReddy, Babu J. N.Schieber, Nicole L.Fajardo, AlbaRupérez, CeliaFernández-Vidal, AndreaRentero Alfonso, CarlesTebar Ramon, FrancescEnrich Bastús, CarlesParton, Robert G.Gross, Steven P.Pol i Sorolla, AlbertMetabolisme dels lípidsTransport biològicMitocondrisMicrotúbulsLipid metabolismBiological transportMitochondriaMicrotubulesLipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD-mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.Nature Publishing Group2017201720152017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion14 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/118508Articles publicats en revistes (Biomedicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/ncomms8176Nature Communications, 2015, vol. 6, p. 7176https://doi.org/10.1038/ncomms8176cc-by (c) Herms, Albert et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1185082026-05-29T05:05:01Z
dc.title.none.fl_str_mv AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
title AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
spellingShingle AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
Herms Fiol, Albert
Metabolisme dels lípids
Transport biològic
Mitocondris
Microtúbuls
Lipid metabolism
Biological transport
Mitochondria
Microtubules
title_short AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
title_full AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
title_fullStr AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
title_full_unstemmed AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
title_sort AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation
dc.creator.none.fl_str_mv Herms Fiol, Albert
Bosch i Rodríguez, Marta
Reddy, Babu J. N.
Schieber, Nicole L.
Fajardo, Alba
Rupérez, Celia
Fernández-Vidal, Andrea
Rentero Alfonso, Carles
Tebar Ramon, Francesc
Enrich Bastús, Carles
Parton, Robert G.
Gross, Steven P.
Pol i Sorolla, Albert
author Herms Fiol, Albert
author_facet Herms Fiol, Albert
Bosch i Rodríguez, Marta
Reddy, Babu J. N.
Schieber, Nicole L.
Fajardo, Alba
Rupérez, Celia
Fernández-Vidal, Andrea
Rentero Alfonso, Carles
Tebar Ramon, Francesc
Enrich Bastús, Carles
Parton, Robert G.
Gross, Steven P.
Pol i Sorolla, Albert
author_role author
author2 Bosch i Rodríguez, Marta
Reddy, Babu J. N.
Schieber, Nicole L.
Fajardo, Alba
Rupérez, Celia
Fernández-Vidal, Andrea
Rentero Alfonso, Carles
Tebar Ramon, Francesc
Enrich Bastús, Carles
Parton, Robert G.
Gross, Steven P.
Pol i Sorolla, Albert
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Metabolisme dels lípids
Transport biològic
Mitocondris
Microtúbuls
Lipid metabolism
Biological transport
Mitochondria
Microtubules
topic Metabolisme dels lípids
Transport biològic
Mitocondris
Microtúbuls
Lipid metabolism
Biological transport
Mitochondria
Microtubules
description Lipid droplets (LDs) are intracellular organelles that provide fatty acids (FAs) to cellular processes including synthesis of membranes and production of metabolic energy. While known to move bidirectionally along microtubules (MTs), the role of LD motion and whether it facilitates interaction with other organelles are unclear. Here we show that during nutrient starvation, LDs and mitochondria relocate on detyrosinated MT from the cell centre to adopt a dispersed distribution. In the cell periphery, LD-mitochondria interactions increase and LDs efficiently supply FAs for mitochondrial beta-oxidation. This cellular adaptation requires the activation of the energy sensor AMPK, which in response to starvation simultaneously increases LD motion, reorganizes the network of detyrosinated MTs and activates mitochondria. In conclusion, we describe the existence of a specialized cellular network connecting the cellular energetic status and MT dynamics to coordinate the functioning of LDs and mitochondria during nutrient scarcity.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/118508
url https://hdl.handle.net/2445/118508
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/ncomms8176
Nature Communications, 2015, vol. 6, p. 7176
https://doi.org/10.1038/ncomms8176
dc.rights.none.fl_str_mv cc-by (c) Herms, Albert et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Herms, Albert et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Biomedicina)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869420027709489152
score 15,811543

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