Basal forebrain atrophy along the Alzheimer's disease continuum in adults with Down syndrome

BackgroundBasal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. MethodsWe included 23...

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Detalles Bibliográficos
Autores: Aranha, MR, Iulita M.F., Montal V., Pegueroles J., Bejanin A., Vaqué-Alcázar L., Grothe M.J., Carmona-Iragui M., Videla L., Benejam B., Arranz J., Padilla C., Valldeneu S., Barroeta I., Altuna M., Fernández S., Ribas L., Valle-Tamayo N., Alcolea D., González-Ortiz S., Bargalló N., Zetterberg H., Blennow K., Blesa R., Wisniewski T., Busciglio J., Cuello A.C., Lleó A., Fortea J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p16235
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=16235
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
basal forebrain
biomarkers
cholinergic
Down syndrome
magnetic resonance imaging
neuroimaging
volumetry
Descripción
Sumario:BackgroundBasal forebrain (BF) degeneration occurs in Down syndrome (DS)-associated Alzheimer's disease (AD). However, the dynamics of BF atrophy with age and disease progression, its impact on cognition, and its relationship with AD biomarkers have not been studied in DS. MethodsWe included 234 adults with DS (150 asymptomatic, 38 prodromal AD, and 46 AD dementia) and 147 euploid controls. BF volumes were extracted from T-weighted magnetic resonance images using a stereotactic atlas in SPM12. We assessed BF volume changes with age and along the clinical AD continuum and their relationship to cognitive performance, cerebrospinal fluid (CSF) and plasma amyloid/tau/neurodegeneration biomarkers, and hippocampal volume. ResultsIn DS, BF volumes decreased with age and along the clinical AD continuum and significantly correlated with amyloid, tau, and neurofilament light chain changes in CSF and plasma, hippocampal volume, and cognitive performance. DiscussionBF atrophy is a potentially valuable neuroimaging biomarker of AD-related cholinergic neurodegeneration in DS.

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