Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats

Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparie...

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Autores: Barrios Sabador, Vicente, Puebla Jiménez, Lilian|||0000-0002-0681-3235, Boyano Adánez, María del Carmen|||0000-0003-2799-6613, Sanz, Manuel, Soriano Guillén, Leandro, Arilla Ferreiro, Eduardo
Tipo de recurso: artículo
Fecha de publicación:2005
País:España
Institución:Universidad de Alcalá (UAH)
Repositorio:e_Buah Biblioteca Digital Universidad de Alcalá
Idioma:inglés
OAI Identifier:oai:ebuah.uah.es:10017/2247
Acceso en línea:http://hdl.handle.net/10017/2247
https://dx.doi.org/10.1016/j.lfs.2005.01.019
Access Level:acceso abierto
Palabra clave:Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Bioquímica
Ciencia
Biochemistry
Science
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spelling Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient ratsBarrios Sabador, VicentePuebla Jiménez, Lilian|||0000-0002-0681-3235Boyano Adánez, María del Carmen|||0000-0003-2799-6613Sanz, ManuelSoriano Guillén, LeandroArilla Ferreiro, EduardoEthanolSomatostatinGestationFrontoparietal cortexAdenylyl cyclaseVirgin ratsBioquímicaCienciaBiochemistryScienceChronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.Ministerio de Ciencia y TecnologíaInstituto de Salud Carlos IIIElsevier20052005-01-01journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10017/2247https://dx.doi.org/10.1016/j.lfs.2005.01.019reponame:e_Buah Biblioteca Digital Universidad de Alcaláinstname:Universidad de Alcalá (UAH)InglésengMICYT Not available SAF2003-08052 ESTUDIO DEL SISTEMA SOMATOSTATINÉRGICO DEL SISTEMA NERVIOSO CENTRAL DE LA RATA LEWIS CON ENCEFALOMIELITIS ALÉRGICA EXPERIMENTALNot available Not available Not availableopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ebuah.uah.es:10017/22472026-06-18T11:13:07Z
dc.title.none.fl_str_mv Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
title Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
spellingShingle Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
Barrios Sabador, Vicente
Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Bioquímica
Ciencia
Biochemistry
Science
title_short Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
title_full Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
title_fullStr Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
title_full_unstemmed Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
title_sort Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
dc.creator.none.fl_str_mv Barrios Sabador, Vicente
Puebla Jiménez, Lilian|||0000-0002-0681-3235
Boyano Adánez, María del Carmen|||0000-0003-2799-6613
Sanz, Manuel
Soriano Guillén, Leandro
Arilla Ferreiro, Eduardo
author Barrios Sabador, Vicente
author_facet Barrios Sabador, Vicente
Puebla Jiménez, Lilian|||0000-0002-0681-3235
Boyano Adánez, María del Carmen|||0000-0003-2799-6613
Sanz, Manuel
Soriano Guillén, Leandro
Arilla Ferreiro, Eduardo
author_role author
author2 Puebla Jiménez, Lilian|||0000-0002-0681-3235
Boyano Adánez, María del Carmen|||0000-0003-2799-6613
Sanz, Manuel
Soriano Guillén, Leandro
Arilla Ferreiro, Eduardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Bioquímica
Ciencia
Biochemistry
Science
topic Ethanol
Somatostatin
Gestation
Frontoparietal cortex
Adenylyl cyclase
Virgin rats
Bioquímica
Ciencia
Biochemistry
Science
description Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.
publishDate 2005
dc.date.none.fl_str_mv 2005
2005-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10017/2247
https://dx.doi.org/10.1016/j.lfs.2005.01.019
url http://hdl.handle.net/10017/2247
https://dx.doi.org/10.1016/j.lfs.2005.01.019
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv MICYT Not available SAF2003-08052 ESTUDIO DEL SISTEMA SOMATOSTATINÉRGICO DEL SISTEMA NERVIOSO CENTRAL DE LA RATA LEWIS CON ENCEFALOMIELITIS ALÉRGICA EXPERIMENTAL
Not available Not available Not available
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:e_Buah Biblioteca Digital Universidad de Alcalá
instname:Universidad de Alcalá (UAH)
instname_str Universidad de Alcalá (UAH)
reponame_str e_Buah Biblioteca Digital Universidad de Alcalá
collection e_Buah Biblioteca Digital Universidad de Alcalá
repository.name.fl_str_mv
repository.mail.fl_str_mv
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