Editorial: Purinergic Signaling 2020: the State-of-The-Art commented by the members of the Italian Purine Club
The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating the guinea-pig taenia coli (Burnstock et al., 1966). This signaling syste...
| Authors: | , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2021 |
| Country: | España |
| Institution: | Universidad de Barcelona |
| Repository: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/223267 |
| Online Access: | https://hdl.handle.net/2445/223267 |
| Access Level: | Open access |
| Keyword: | Trifosfat d'adenosina Purines Animals Adenosine triphospahatase |
| Summary: | The “purinergic signaling” term was coined in 1972 by Geoffrey Burnstock Burnstock et al. after demonstrating that adenosine 5’-triphosphate (ATP) is a transmitter in nonadrenergic, noncholinergic inhibitory nerves innervating the guinea-pig taenia coli (Burnstock et al., 1966). This signaling system, which is ubiquitously expressed in every organ and system of the body, comprises various ecto-, soluble and intracellularly localized enzymes, nucleoside transporters, and G protein-coupled and ligand-gated cation channel receptors. Through the purinergic signaling system cells can maintain basal adenine and guanine-based purines at certain steady-state levels, thereby contributing to preserve the purines-dependent cellular homeostasis. |
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