Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies

Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB)...

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Autores: Garcia Esparcia, Paula, Diaz-Lucena, Daniela, Ainciburu, Marina, Torrejón-Escribano, Benjamín, Carmona Murillo, Margarita, Llorens Torres, Franc, Ferrer, Isidro (Ferrer Abizanda)
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/123917
Acceso en línea:https://hdl.handle.net/2445/123917
Access Level:acceso abierto
Palabra clave:Malaltia d'Alzheimer
Àcid glutàmic
Transport biològic
Alzheimer's disease
Glutamic acid
Biological transport
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spelling Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy BodiesGarcia Esparcia, PaulaDiaz-Lucena, DanielaAinciburu, MarinaTorrejón-Escribano, BenjamínCarmona Murillo, MargaritaLlorens Torres, FrancFerrer, Isidro (Ferrer Abizanda)Malaltia d'AlzheimerÀcid glutàmicTransport biològicAlzheimer's diseaseGlutamic acidBiological transportGlutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain understanding of astrogliopathy in diseases manifested by dementia. Glial fibrillary acidic protein (GFAP) mRNA expression is significantly increased in AD but not in DLB, whereas GLT1, vesicular glutamate transporter 1 (vGLUT1) and aldehyde dehydrogenase 1 family member 1 (ALDH1L1) are not modified in AD and DLB when compared with controls. GLT1 protein levels are not altered in AD and DLB but GFAP and ALDH1L1 are significantly increased in AD, and GFAP in DLB. As a result, a non-significant decrease in the ratio between GLT1 and GFAP, and between GLT1 and ALDH1L1, is found in both AD and DLB. Double-labeling immunofluorescence and confocal microscopy revealed no visible reduction of GLT1 immunoreactivity in relation to beta-amyloid plaques in AD. These data suggest a subtle imbalance between GLT1, and GFAP and ALDH1L1 expression, with limited consequences in glutamate transport.Frontiers Media Sa2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion8 p.application/pdfhttps://hdl.handle.net/2445/123917Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00122Frontiers In Aging Neuroscience, 2018, Vol. 10, Article 122https://doi.org/10.3389/fnagi.2018.00122cc by (c) Garcia-Esparcia, Paula et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1239172026-05-29T05:05:01Z
dc.title.none.fl_str_mv Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
title Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
spellingShingle Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
Garcia Esparcia, Paula
Malaltia d'Alzheimer
Àcid glutàmic
Transport biològic
Alzheimer's disease
Glutamic acid
Biological transport
title_short Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
title_full Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
title_fullStr Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
title_full_unstemmed Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
title_sort Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
dc.creator.none.fl_str_mv Garcia Esparcia, Paula
Diaz-Lucena, Daniela
Ainciburu, Marina
Torrejón-Escribano, Benjamín
Carmona Murillo, Margarita
Llorens Torres, Franc
Ferrer, Isidro (Ferrer Abizanda)
author Garcia Esparcia, Paula
author_facet Garcia Esparcia, Paula
Diaz-Lucena, Daniela
Ainciburu, Marina
Torrejón-Escribano, Benjamín
Carmona Murillo, Margarita
Llorens Torres, Franc
Ferrer, Isidro (Ferrer Abizanda)
author_role author
author2 Diaz-Lucena, Daniela
Ainciburu, Marina
Torrejón-Escribano, Benjamín
Carmona Murillo, Margarita
Llorens Torres, Franc
Ferrer, Isidro (Ferrer Abizanda)
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Malaltia d'Alzheimer
Àcid glutàmic
Transport biològic
Alzheimer's disease
Glutamic acid
Biological transport
topic Malaltia d'Alzheimer
Àcid glutàmic
Transport biològic
Alzheimer's disease
Glutamic acid
Biological transport
description Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of Alzheimer disease (AD) and terminal stages of dementia with Lewy bodies (DLB) in order to gain understanding of astrogliopathy in diseases manifested by dementia. Glial fibrillary acidic protein (GFAP) mRNA expression is significantly increased in AD but not in DLB, whereas GLT1, vesicular glutamate transporter 1 (vGLUT1) and aldehyde dehydrogenase 1 family member 1 (ALDH1L1) are not modified in AD and DLB when compared with controls. GLT1 protein levels are not altered in AD and DLB but GFAP and ALDH1L1 are significantly increased in AD, and GFAP in DLB. As a result, a non-significant decrease in the ratio between GLT1 and GFAP, and between GLT1 and ALDH1L1, is found in both AD and DLB. Double-labeling immunofluorescence and confocal microscopy revealed no visible reduction of GLT1 immunoreactivity in relation to beta-amyloid plaques in AD. These data suggest a subtle imbalance between GLT1, and GFAP and ALDH1L1 expression, with limited consequences in glutamate transport.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/123917
url https://hdl.handle.net/2445/123917
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3389/fnagi.2018.00122
Frontiers In Aging Neuroscience, 2018, Vol. 10, Article 122
https://doi.org/10.3389/fnagi.2018.00122
dc.rights.none.fl_str_mv cc by (c) Garcia-Esparcia, Paula et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Garcia-Esparcia, Paula et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 8 p.
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419981478821889
score 15,812455

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