Brain networks alterations in cocaine use and gambling disorders during emotion regulation

Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumpti...

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Autores: Picó-Pérez, Maria|||0000-0002-1573-2445, Costumero, Víctor, Verdejo-Román, Juan, Albein-Urios, Natalia, Martínez-González, José Miguel, Soriano-Mas, Carles|||0000-0003-4574-6597, Barrós-Loscertales, Alfonso|||0000-0002-2456-6653, Verdejo-Garcia, Antonio|||0000-0001-8874-9339
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Universitat Autònoma de Barcelona
Repositório:Dipòsit Digital de Documents de la UAB
Idioma:inglês
OAI Identifier:oai:ddd.uab.cat:268763
Acesso em linha:https://ddd.uab.cat/record/268763
https://dx.doi.org/urn:doi:10.1556/2006.2022.00018
Access Level:Acceso aberto
Palavra-chave:Addiction
Cocaine
Emotion regulation
Fmri
Gambling
Independent-component analysis
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spelling Brain networks alterations in cocaine use and gambling disorders during emotion regulationPicó-Pérez, Maria|||0000-0002-1573-2445Costumero, VíctorVerdejo-Román, JuanAlbein-Urios, NataliaMartínez-González, José MiguelSoriano-Mas, Carles|||0000-0003-4574-6597Barrós-Loscertales, Alfonso|||0000-0002-2456-6653Verdejo-Garcia, Antonio|||0000-0001-8874-9339AddictionCocaineEmotion regulationFmriGamblingIndependent-component analysisCocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumption in CUD as compared to GD. Neuroimaging research aimed at disentangling their shared and specific alterations can contribute to improve understanding of both disorders. We compared CUD (N = 15), GD (N = 16) and healthy comparison (HC; N = 17) groups using a network-based approach for studying temporally coherent functional networks during functional magnetic resonance imaging (fMRI) of an emotion regulation task. We focused our analysis in limbic, ventral frontostriatal, dorsal attentional (DAN) and executive networks (FPN), given their involvement in emotion regulation and their alteration in CUD and GD. Correlations with measures of emotional experience and impulsivity (UPPS-P) were also performed. The limbic network was significantly decreased during emotional processing both for CUD and GD individuals compared to the HC group. Furthermore, GD participants compared to HC showed an increased activation in the ventral frontostriatal network during emotion regulation. Finally, networks' activation patterns were modulated by impulsivity traits. Functional network analyses revealed both overlapping and unique effects of stimulant and gambling addictions on neural networks underpinning emotion regulation. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/268763https://dx.doi.org/urn:doi:10.1556/2006.2022.00018reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 IJC2019-041916-Iopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2687632026-06-06T12:50:31Z
dc.title.none.fl_str_mv Brain networks alterations in cocaine use and gambling disorders during emotion regulation
title Brain networks alterations in cocaine use and gambling disorders during emotion regulation
spellingShingle Brain networks alterations in cocaine use and gambling disorders during emotion regulation
Picó-Pérez, Maria|||0000-0002-1573-2445
Addiction
Cocaine
Emotion regulation
Fmri
Gambling
Independent-component analysis
title_short Brain networks alterations in cocaine use and gambling disorders during emotion regulation
title_full Brain networks alterations in cocaine use and gambling disorders during emotion regulation
title_fullStr Brain networks alterations in cocaine use and gambling disorders during emotion regulation
title_full_unstemmed Brain networks alterations in cocaine use and gambling disorders during emotion regulation
title_sort Brain networks alterations in cocaine use and gambling disorders during emotion regulation
dc.creator.none.fl_str_mv Picó-Pérez, Maria|||0000-0002-1573-2445
Costumero, Víctor
Verdejo-Román, Juan
Albein-Urios, Natalia
Martínez-González, José Miguel
Soriano-Mas, Carles|||0000-0003-4574-6597
Barrós-Loscertales, Alfonso|||0000-0002-2456-6653
Verdejo-Garcia, Antonio|||0000-0001-8874-9339
author Picó-Pérez, Maria|||0000-0002-1573-2445
author_facet Picó-Pérez, Maria|||0000-0002-1573-2445
Costumero, Víctor
Verdejo-Román, Juan
Albein-Urios, Natalia
Martínez-González, José Miguel
Soriano-Mas, Carles|||0000-0003-4574-6597
Barrós-Loscertales, Alfonso|||0000-0002-2456-6653
Verdejo-Garcia, Antonio|||0000-0001-8874-9339
author_role author
author2 Costumero, Víctor
Verdejo-Román, Juan
Albein-Urios, Natalia
Martínez-González, José Miguel
Soriano-Mas, Carles|||0000-0003-4574-6597
Barrós-Loscertales, Alfonso|||0000-0002-2456-6653
Verdejo-Garcia, Antonio|||0000-0001-8874-9339
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Addiction
Cocaine
Emotion regulation
Fmri
Gambling
Independent-component analysis
topic Addiction
Cocaine
Emotion regulation
Fmri
Gambling
Independent-component analysis
description Cocaine use disorder (CUD) and gambling disorder (GD) share clinical features and neural alterations, including emotion regulation deficits and dysfunctional activation in related networks. However, they also exhibit differential aspects, such as the neuroadaptive effects of long-term drug consumption in CUD as compared to GD. Neuroimaging research aimed at disentangling their shared and specific alterations can contribute to improve understanding of both disorders. We compared CUD (N = 15), GD (N = 16) and healthy comparison (HC; N = 17) groups using a network-based approach for studying temporally coherent functional networks during functional magnetic resonance imaging (fMRI) of an emotion regulation task. We focused our analysis in limbic, ventral frontostriatal, dorsal attentional (DAN) and executive networks (FPN), given their involvement in emotion regulation and their alteration in CUD and GD. Correlations with measures of emotional experience and impulsivity (UPPS-P) were also performed. The limbic network was significantly decreased during emotional processing both for CUD and GD individuals compared to the HC group. Furthermore, GD participants compared to HC showed an increased activation in the ventral frontostriatal network during emotion regulation. Finally, networks' activation patterns were modulated by impulsivity traits. Functional network analyses revealed both overlapping and unique effects of stimulant and gambling addictions on neural networks underpinning emotion regulation.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/268763
https://dx.doi.org/urn:doi:10.1556/2006.2022.00018
url https://ddd.uab.cat/record/268763
https://dx.doi.org/urn:doi:10.1556/2006.2022.00018
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 IJC2019-041916-I
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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