Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker

© 2021 The Authors.

Detalles Bibliográficos
Autores: Lozano-Prieto, Marta, Adlam, David, García-Guimaraes, Marcos, Sanz-García, Ancor, Vera-Tomé, Paula, Rivero, Fernando, Cuesta, Javier, Bastante, Teresa, Baranowska-Clarke, Anna A., Vara, Alicia, Martín-Gayo, Enrique, Vicente-Manzanares, Miguel, Martín, Pilar, Samani, Nilesh J., Sánchez-Madrid, Francisco, Alfonso, Fernando, Fuente, Hortensia de la
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/261329
Acceso en línea:http://hdl.handle.net/10261/261329
Access Level:acceso abierto
Palabra clave:Spontaneous coronary artery dissection
MicroRNAs
Acute myocardial infarction
Biomarkers
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oai_identifier_str oai:digital.csic.es:10261/261329
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
title Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
spellingShingle Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
Lozano-Prieto, Marta
Spontaneous coronary artery dissection
MicroRNAs
Acute myocardial infarction
Biomarkers
title_short Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
title_full Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
title_fullStr Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
title_full_unstemmed Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
title_sort Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarker
dc.creator.none.fl_str_mv Lozano-Prieto, Marta
Adlam, David
García-Guimaraes, Marcos
Sanz-García, Ancor
Vera-Tomé, Paula
Rivero, Fernando
Cuesta, Javier
Bastante, Teresa
Baranowska-Clarke, Anna A.
Vara, Alicia
Martín-Gayo, Enrique
Vicente-Manzanares, Miguel
Martín, Pilar
Samani, Nilesh J.
Sánchez-Madrid, Francisco
Alfonso, Fernando
Fuente, Hortensia de la
author Lozano-Prieto, Marta
author_facet Lozano-Prieto, Marta
Adlam, David
García-Guimaraes, Marcos
Sanz-García, Ancor
Vera-Tomé, Paula
Rivero, Fernando
Cuesta, Javier
Bastante, Teresa
Baranowska-Clarke, Anna A.
Vara, Alicia
Martín-Gayo, Enrique
Vicente-Manzanares, Miguel
Martín, Pilar
Samani, Nilesh J.
Sánchez-Madrid, Francisco
Alfonso, Fernando
Fuente, Hortensia de la
author_role author
author2 Adlam, David
García-Guimaraes, Marcos
Sanz-García, Ancor
Vera-Tomé, Paula
Rivero, Fernando
Cuesta, Javier
Bastante, Teresa
Baranowska-Clarke, Anna A.
Vara, Alicia
Martín-Gayo, Enrique
Vicente-Manzanares, Miguel
Martín, Pilar
Samani, Nilesh J.
Sánchez-Madrid, Francisco
Alfonso, Fernando
Fuente, Hortensia de la
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Agencia Estatal de Investigación (España)
Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (España)
Fundación BBVA
Fundación la Caixa
Instituto de Salud Carlos III
Comunidad de Madrid
British Heart Foundation
NIHR Biomedical Research Centre (UK)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Spontaneous coronary artery dissection
MicroRNAs
Acute myocardial infarction
Biomarkers
topic Spontaneous coronary artery dissection
MicroRNAs
Acute myocardial infarction
Biomarkers
description © 2021 The Authors.
publishDate 2021
dc.date.none.fl_str_mv 2021
2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/261329
url http://hdl.handle.net/10261/261329
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
#PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82886-R
S2017/BMD-3671-INFLAMUNE-CM
http://dx.doi.org/10.1016/j.ebiom.2021.103338
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419973041979392
spelling Differential miRNAs in acute spontaneous coronary artery dissection: Pathophysiological insights from a potential biomarkerLozano-Prieto, MartaAdlam, DavidGarcía-Guimaraes, MarcosSanz-García, AncorVera-Tomé, PaulaRivero, FernandoCuesta, JavierBastante, TeresaBaranowska-Clarke, Anna A.Vara, AliciaMartín-Gayo, EnriqueVicente-Manzanares, MiguelMartín, PilarSamani, Nilesh J.Sánchez-Madrid, FranciscoAlfonso, FernandoFuente, Hortensia de laSpontaneous coronary artery dissectionMicroRNAsAcute myocardial infarctionBiomarkers© 2021 The Authors.[Background]: Spontaneous Coronary Artery Dissection (SCAD) is an important cause of acute coronary syndromes, particularly in young to middle-aged women. Differentiating acute SCAD from coronary atherothrombosis remains a major clinical challenge. [Methods]: A case-control study was used to explore the usefulness of circulating miRNAs to discriminate both clinical entities. The profile of miRNAs was evaluated using an unbiased human RT-PCR platform and confirmed using individual primers. miRNAs were evaluated in plasma samples from acute SCAD and atherothrombotic acute myocardial infarction (AT-AMI) from two independent cohorts; discovery cohort (SCAD n = 15, AT-AMI n = 15), and validation cohort (SCAD n = 11, AT-AMI n = 41) with 9 healthy control subjects. Plasma levels of IL-8, TGFB1, TGBR1, Endothelin-1 and MMP2 were analysed by ELISA assays. [Findings]: From 15 differentially expressed miRNAs detected in cohort 1, we confirmed in cohort 2 the differential expression of 4 miRNAs: miR-let-7f-5p, miR-146a-5p, miR-151a-3p and miR-223-5p, whose expression was higher in SCAD compared to AT-AMI. The combined expression of these 4 miRNAs showed the best predictive value to distinguish between both entities (AUC: 0.879, 95% CI 0.72–1.0) compared to individual miRNAs. Functional profiling of target genes identified an association with blood vessel biology, TGF-beta pathway and cytoskeletal traction force. ELISA assays showed high plasma levels of IL-8, TGFB1, TGFBR1, Endothelin-1 and MMP2 in SCAD patients compared to AT-AMI. [Interpretation]: We present a novel signature of plasma miRNAs in patients with SCAD. miR-let-7f-5p, miR-146a-5p, miR-151a-3p and miR-223-5p discriminate SCAD from AT-AMI patients and also shed light on the pathological mechanisms underlying this condition. [Funding]: Spanish Ministry of Economy and Competitiveness (MINECO): Plan Nacional de Salud SAF2017-82886-R, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV). Fundación BBVA a equipos de Investigación Científica 2018 and from Caixa Banking Foundation under the project code HR17-00016 to F.S.M. Instituto de Salud Carlos III (AES 2019): PI19/00565 to F.R, PI19/00545 to P.M. CAM (S2017/BMD-3671-INFLAMUNE-CM) from Comunidad de Madrid to FSM and PM. The UK SCAD study was supported by BeatSCAD, the British Heart Foundation (BHF) PG/13/96/30608 the NIHR rare disease translational collaboration and the Leicester NIHR Biomedical Research Centre.Spanish Ministry of Economy and Competitiveness (MINECO): Plan Nacional de Salud SAF2017-82886-R, Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV). Fundación BBVA a equipos de Investigación Científica 2018 and from Caixa Banking Foundation under the project code HR17-00016 to F.S.M. Instituto de Salud Carlos III (AES 2019): PI19/00565 to F.R, PI19/00545 to P.M. CAM (S2017/BMD-3671-INFLAMUNE-CM) from Comunidad de Madrid to FSM and PM. The UK SCAD study was supported by BeatSCAD, the British Heart Foundation (BHF) PG/13/96/30608 the NIHR rare disease translational collaboration and the Leicester NIHR Biomedical Research Centre.ElsevierMinisterio de Economía y Competitividad (España)Agencia Estatal de Investigación (España)Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (España)Fundación BBVAFundación la CaixaInstituto de Salud Carlos IIIComunidad de MadridBritish Heart FoundationNIHR Biomedical Research Centre (UK)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2022202220212022info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/261329reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE##PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/SAF2017-82886-RS2017/BMD-3671-INFLAMUNE-CMhttp://dx.doi.org/10.1016/j.ebiom.2021.103338Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2613292026-05-22T06:33:51Z
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