Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling

[EN] Constrained mixture models of soft tissue growth and remodeling can simulate many evolving conditions in health as well as in disease and its treatment, but they can be computationally expensive. In this paper, we derive a new fast, robust finite element implementation based on a concept of mec...

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Autores: Latorre, Marcos|||0000-0003-4142-0207, Humphrey, Jay D.
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/191439
Acceso en línea:https://riunet.upv.es/handle/10251/191439
Access Level:acceso abierto
Palabra clave:Growth
Remodeling
Constrained mixture
Mechanobiology
Artery
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
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spelling Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodelingLatorre, Marcos|||0000-0003-4142-0207Humphrey, Jay D.GrowthRemodelingConstrained mixtureMechanobiologyArtery03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades[EN] Constrained mixture models of soft tissue growth and remodeling can simulate many evolving conditions in health as well as in disease and its treatment, but they can be computationally expensive. In this paper, we derive a new fast, robust finite element implementation based on a concept of mechanobiological equilibrium that yields fully resolved solutions and allows computation of quasi-equilibrated evolutions when imposed perturbations are slow relative to the adaptive process. We demonstrate quadratic convergence and verify the model via comparisons with semi-analytical solutions for arterial mechanics. We further examine the enlargement of aortic aneurysms for which we identify new mechanobiological insights into factors that affect the nearby non-aneurysmal segment as it responds to the changing mechanics within the diseased segment. Because this new 3D approach can be implemented within many existing finite element solvers, constrained mixture models of growth and remodeling can now be used more widely.This work was supported, in part, by grants from the NIH, USA (R01 HL128602, P01 HL134605, U01 HL142518) and DoD, USA (W81 XWH1810518)ElsevierDepartamento de Mecánica de los Medios Continuos y Teoría de EstructurasEscuela Técnica Superior de Ingeniería IndustrialCentro de Investigación e Innovación en BioingenieríaU.S. Department of DefenseNational Institutes of Health, EEUURepositorio Institucional de la Universitat Politècnica de València Riunet20202020-08-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttps://riunet.upv.es/handle/10251/191439reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 R01 HL128602 Computational Model Driven Design of Tissue Engineered Vascular GraftsNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 P01 HL134605 Endothelial Mechanotransduction in Thoracic Aneurysm Formation and ProgressionNational Institutes of Health, EEUU https://doi.org/10.13039/100000002 U01 HL142518 Multimodality imaging-driven multifidelity modeling of aortic dissectionU.S. Department of Defense https://doi.org/10.13039/100000005 W81 XWH1810518 Development and Preclinical Validation of an Improved Tissue-Engineered Vascular Graft for Use in Congenital Surgeryopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento - No comercial - Sin obra derivada (by-nc-nd) http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1914392026-06-13T07:49:27Z
dc.title.none.fl_str_mv Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
title Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
spellingShingle Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
Latorre, Marcos|||0000-0003-4142-0207
Growth
Remodeling
Constrained mixture
Mechanobiology
Artery
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
title_short Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
title_full Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
title_fullStr Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
title_full_unstemmed Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
title_sort Fast, rate-independent, finite element implementation of a 3D constrained mixture model of soft tissue growth and remodeling
dc.creator.none.fl_str_mv Latorre, Marcos|||0000-0003-4142-0207
Humphrey, Jay D.
author Latorre, Marcos|||0000-0003-4142-0207
author_facet Latorre, Marcos|||0000-0003-4142-0207
Humphrey, Jay D.
author_role author
author2 Humphrey, Jay D.
author2_role author
dc.contributor.none.fl_str_mv Departamento de Mecánica de los Medios Continuos y Teoría de Estructuras
Escuela Técnica Superior de Ingeniería Industrial
Centro de Investigación e Innovación en Bioingeniería
U.S. Department of Defense
National Institutes of Health, EEUU
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Growth
Remodeling
Constrained mixture
Mechanobiology
Artery
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
topic Growth
Remodeling
Constrained mixture
Mechanobiology
Artery
03.- Garantizar una vida saludable y promover el bienestar para todos y todas en todas las edades
description [EN] Constrained mixture models of soft tissue growth and remodeling can simulate many evolving conditions in health as well as in disease and its treatment, but they can be computationally expensive. In this paper, we derive a new fast, robust finite element implementation based on a concept of mechanobiological equilibrium that yields fully resolved solutions and allows computation of quasi-equilibrated evolutions when imposed perturbations are slow relative to the adaptive process. We demonstrate quadratic convergence and verify the model via comparisons with semi-analytical solutions for arterial mechanics. We further examine the enlargement of aortic aneurysms for which we identify new mechanobiological insights into factors that affect the nearby non-aneurysmal segment as it responds to the changing mechanics within the diseased segment. Because this new 3D approach can be implemented within many existing finite element solvers, constrained mixture models of growth and remodeling can now be used more widely.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-08-15
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/191439
url https://riunet.upv.es/handle/10251/191439
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv National Institutes of Health, EEUU https://doi.org/10.13039/100000002 R01 HL128602 Computational Model Driven Design of Tissue Engineered Vascular Grafts
National Institutes of Health, EEUU https://doi.org/10.13039/100000002 P01 HL134605 Endothelial Mechanotransduction in Thoracic Aneurysm Formation and Progression
National Institutes of Health, EEUU https://doi.org/10.13039/100000002 U01 HL142518 Multimodality imaging-driven multifidelity modeling of aortic dissection
U.S. Department of Defense https://doi.org/10.13039/100000005 W81 XWH1810518 Development and Preclinical Validation of an Improved Tissue-Engineered Vascular Graft for Use in Congenital Surgery
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento - No comercial - Sin obra derivada (by-nc-nd)
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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