Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study

Background: Clinical control in chronic obstructive pulmonary disease (COPD) has not been completely characterized. A proposal of clinical control criteria (CCC) has been recently defined and validated as a tool for determining control, but there is scarce information on patients with severe COPD. O...

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Autores: Jose Soler-Cataluna, Juan, Almagro, Pere, Huerta, Arturo, Gonzalez-Segura, Diego, Cosio, Borja G.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p10378
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/10378
Access Level:acceso abierto
Palabra clave:COPD
control
clinical
exacerbations
criteria
CAT
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spelling Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE StudyJose Soler-Cataluna, JuanAlmagro, PereHuerta, ArturoGonzalez-Segura, DiegoCosio, Borja G.COPDcontrolclinicalexacerbationscriteriaCATBackground: Clinical control in chronic obstructive pulmonary disease (COPD) has not been completely characterized. A proposal of clinical control criteria (CCC) has been recently defined and validated as a tool for determining control, but there is scarce information on patients with severe COPD. Objective: To evaluate clinical control in severe COPD using the CCC. Patients and Methods: The study design was observational, multicenter, cross-sectional study involving 4801 patients with severe COPD in Spain. Clinical control was defined according to clinical impact (dyspnea grade, use of rescue treatment in last week, sputum color, and daily physical activity) and stability (exacerbations in last 3 months and patient's perception about health status). Clinical control of COPD was alternatively evaluated with the COPD assessment test (CAT) and the presence of exacerbations in the last 3 months. Results: According to CCC, 61.0% of patients had low clinical impact, and 41.4% showed clinical stability. Overall, 29.9% of patients had both low clinical impact and stability (controlled), whereas 70.1% showed high clinical impact and/or no clinical stability (non-controlled). COPD control was also assessed by using only the definition of CAT <= 16 and no exacerbations in the last 3 months. Results obtained with this definition were similar to those obtained by CCC, and the concordance between both definitions was high (Kappa index = 0.698). Conclusion: By using the CCC, approximately only one third of patients with severe COPD were considered as controlled. Physical activity, adherence to inhalers, age, post-bronchodilator FEV1, age-adjusted Charlson comorbidity index, and healthcare level were independent factors associated with COPD control.DOVE MEDICAL PRESS LTD2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/10378International Journal of Chronic Obstructive Pulmonary DiseaseISSN: 11782005ISSNl: 11769106reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p103782026-06-11T12:45:17Z
dc.title.none.fl_str_mv Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
title Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
spellingShingle Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
Jose Soler-Cataluna, Juan
COPD
control
clinical
exacerbations
criteria
CAT
title_short Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
title_full Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
title_fullStr Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
title_full_unstemmed Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
title_sort Clinical Control Criteria to Determine Disease Control in Patients with Severe COPD: The CLAVE Study
dc.creator.none.fl_str_mv Jose Soler-Cataluna, Juan
Almagro, Pere
Huerta, Arturo
Gonzalez-Segura, Diego
Cosio, Borja G.
author Jose Soler-Cataluna, Juan
author_facet Jose Soler-Cataluna, Juan
Almagro, Pere
Huerta, Arturo
Gonzalez-Segura, Diego
Cosio, Borja G.
author_role author
author2 Almagro, Pere
Huerta, Arturo
Gonzalez-Segura, Diego
Cosio, Borja G.
author2_role author
author
author
author
dc.subject.none.fl_str_mv COPD
control
clinical
exacerbations
criteria
CAT
topic COPD
control
clinical
exacerbations
criteria
CAT
description Background: Clinical control in chronic obstructive pulmonary disease (COPD) has not been completely characterized. A proposal of clinical control criteria (CCC) has been recently defined and validated as a tool for determining control, but there is scarce information on patients with severe COPD. Objective: To evaluate clinical control in severe COPD using the CCC. Patients and Methods: The study design was observational, multicenter, cross-sectional study involving 4801 patients with severe COPD in Spain. Clinical control was defined according to clinical impact (dyspnea grade, use of rescue treatment in last week, sputum color, and daily physical activity) and stability (exacerbations in last 3 months and patient's perception about health status). Clinical control of COPD was alternatively evaluated with the COPD assessment test (CAT) and the presence of exacerbations in the last 3 months. Results: According to CCC, 61.0% of patients had low clinical impact, and 41.4% showed clinical stability. Overall, 29.9% of patients had both low clinical impact and stability (controlled), whereas 70.1% showed high clinical impact and/or no clinical stability (non-controlled). COPD control was also assessed by using only the definition of CAT <= 16 and no exacerbations in the last 3 months. Results obtained with this definition were similar to those obtained by CCC, and the concordance between both definitions was high (Kappa index = 0.698). Conclusion: By using the CCC, approximately only one third of patients with severe COPD were considered as controlled. Physical activity, adherence to inhalers, age, post-bronchodilator FEV1, age-adjusted Charlson comorbidity index, and healthcare level were independent factors associated with COPD control.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/10378
url https://fisabio.portalinvestigacion.com/publicaciones/10378
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
publisher.none.fl_str_mv DOVE MEDICAL PRESS LTD
dc.source.none.fl_str_mv International Journal of Chronic Obstructive Pulmonary Disease
ISSN: 11782005
ISSNl: 11769106
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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