Safety and Efficacy of Solitaire Stent Thrombectomy
Supplemental Digital Content is available in the text. Patient-level data were pooled from trials in which the Solitaire was the only or the predominant device used in a prespecified meta-analysis (SEER Collaboration): Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatmen...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:185801 |
| Acceso en línea: | https://ddd.uab.cat/record/185801 https://dx.doi.org/urn:doi:10.1161/STROKEAHA.115.012360 |
| Access Level: | acceso abierto |
| Palabra clave: | Endovascular treatment Intra-arterial therapy Ischemic stroke Mechanical thrombectomy Meta-analysis Randomized controlled trial Stent retriever device Thrombolysis |
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Safety and Efficacy of Solitaire Stent ThrombectomyCampbell, Bruce C.V|||0000-0003-3632-9433Hill, M. D|||0000-0002-6269-1543Rubiera Del Fueyo, Marta A|||0000-0001-8100-9477Menon, Bijoy K.Demchuk, AndrewDonnan, Geoffrey A.Roy, DanielThornton, JohnDorado Bouix, Laura|||0000-0003-1095-6797Bonafe, AlainLevy, Elad I.Diener, Hans-Christoph|||0000-0002-6556-8612Hernández-Pérez, María|||0000-0001-8279-7954Pereira, Vitor MendesBlasco, JordiQuesada, Helena|||0009-0009-1846-0447Rempel, JeremyJahan, RezaDavis, Stephen M.Stouch, Bruce C.Mitchell, Peter J.Jovin, Tudor G.|||0000-0002-2619-6975Saver, Jeffrey L..Goyal, MayankEndovascular treatmentIntra-arterial therapyIschemic strokeMechanical thrombectomyMeta-analysisRandomized controlled trialStent retriever deviceThrombolysisSupplemental Digital Content is available in the text. Patient-level data were pooled from trials in which the Solitaire was the only or the predominant device used in a prespecified meta-analysis (SEER Collaboration): Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME), Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE), Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial (EXTEND-IA), and Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset (REVASCAT). The primary outcome was ordinal analysis of modified Rankin Score at 90 days. The primary analysis included all patients in the 4 trials with 2 sensitivity analyses: (1) excluding patients in whom Solitaire was not the first device used and (2) including the 3 Solitaire-only trials (excluding ESCAPE). Secondary outcomes included functional independence (modified Rankin Score 0-2), symptomatic intracerebral hemorrhage, and mortality. The primary analysis included 787 patients: 401 randomized to endovascular thrombectomy and 386 to standard care, and 82.6% received intravenous thrombolysis. The common odds ratio for modified Rankin Score improvement was 2.7 (2.0-3.5) with no heterogeneity in effect by age, sex, baseline stroke severity, extent of computed tomography changes, site of occlusion, or pretreatment with alteplase. The number needed to treat to reduce disability was 2.5 and for an extra patient to achieve independent outcome was 4.25 (3.29-5.99). Successful revascularization occurred in 77% treated with Solitaire device. The rate of symptomatic intracerebral hemorrhage and overall mortality did not differ between treatment groups. Solitaire thrombectomy for large vessel ischemic stroke was safe and highly effective with substantially reduced disability. Benefits were consistent in all prespecified subgroups.Universitat Autònoma de Barcelona 22016-01-0120162016-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/185801https://dx.doi.org/urn:doi:10.1161/STROKEAHA.115.012360reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:1858012026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| title |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| spellingShingle |
Safety and Efficacy of Solitaire Stent Thrombectomy Campbell, Bruce C.V|||0000-0003-3632-9433 Endovascular treatment Intra-arterial therapy Ischemic stroke Mechanical thrombectomy Meta-analysis Randomized controlled trial Stent retriever device Thrombolysis |
| title_short |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| title_full |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| title_fullStr |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| title_full_unstemmed |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| title_sort |
Safety and Efficacy of Solitaire Stent Thrombectomy |
| dc.creator.none.fl_str_mv |
Campbell, Bruce C.V|||0000-0003-3632-9433 Hill, M. D|||0000-0002-6269-1543 Rubiera Del Fueyo, Marta A|||0000-0001-8100-9477 Menon, Bijoy K. Demchuk, Andrew Donnan, Geoffrey A. Roy, Daniel Thornton, John Dorado Bouix, Laura|||0000-0003-1095-6797 Bonafe, Alain Levy, Elad I. Diener, Hans-Christoph|||0000-0002-6556-8612 Hernández-Pérez, María|||0000-0001-8279-7954 Pereira, Vitor Mendes Blasco, Jordi Quesada, Helena|||0009-0009-1846-0447 Rempel, Jeremy Jahan, Reza Davis, Stephen M. Stouch, Bruce C. Mitchell, Peter J. Jovin, Tudor G.|||0000-0002-2619-6975 Saver, Jeffrey L.. Goyal, Mayank |
| author |
Campbell, Bruce C.V|||0000-0003-3632-9433 |
| author_facet |
Campbell, Bruce C.V|||0000-0003-3632-9433 Hill, M. D|||0000-0002-6269-1543 Rubiera Del Fueyo, Marta A|||0000-0001-8100-9477 Menon, Bijoy K. Demchuk, Andrew Donnan, Geoffrey A. Roy, Daniel Thornton, John Dorado Bouix, Laura|||0000-0003-1095-6797 Bonafe, Alain Levy, Elad I. Diener, Hans-Christoph|||0000-0002-6556-8612 Hernández-Pérez, María|||0000-0001-8279-7954 Pereira, Vitor Mendes Blasco, Jordi Quesada, Helena|||0009-0009-1846-0447 Rempel, Jeremy Jahan, Reza Davis, Stephen M. Stouch, Bruce C. Mitchell, Peter J. Jovin, Tudor G.|||0000-0002-2619-6975 Saver, Jeffrey L.. Goyal, Mayank |
| author_role |
author |
| author2 |
Hill, M. D|||0000-0002-6269-1543 Rubiera Del Fueyo, Marta A|||0000-0001-8100-9477 Menon, Bijoy K. Demchuk, Andrew Donnan, Geoffrey A. Roy, Daniel Thornton, John Dorado Bouix, Laura|||0000-0003-1095-6797 Bonafe, Alain Levy, Elad I. Diener, Hans-Christoph|||0000-0002-6556-8612 Hernández-Pérez, María|||0000-0001-8279-7954 Pereira, Vitor Mendes Blasco, Jordi Quesada, Helena|||0009-0009-1846-0447 Rempel, Jeremy Jahan, Reza Davis, Stephen M. Stouch, Bruce C. Mitchell, Peter J. Jovin, Tudor G.|||0000-0002-2619-6975 Saver, Jeffrey L.. Goyal, Mayank |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Endovascular treatment Intra-arterial therapy Ischemic stroke Mechanical thrombectomy Meta-analysis Randomized controlled trial Stent retriever device Thrombolysis |
| topic |
Endovascular treatment Intra-arterial therapy Ischemic stroke Mechanical thrombectomy Meta-analysis Randomized controlled trial Stent retriever device Thrombolysis |
| description |
Supplemental Digital Content is available in the text. Patient-level data were pooled from trials in which the Solitaire was the only or the predominant device used in a prespecified meta-analysis (SEER Collaboration): Solitaire FR With the Intention for Thrombectomy as Primary Endovascular Treatment (SWIFT PRIME), Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT to Recanalization Times (ESCAPE), Extending the Time for Thrombolysis in Emergency Neurological Deficits-Intra-Arterial (EXTEND-IA), and Randomized Trial of Revascularization With Solitaire FR Device Versus Best Medical Therapy in the Treatment of Acute Stroke Due to Anterior Circulation Large Vessel Occlusion Presenting Within Eight Hours of Symptom Onset (REVASCAT). The primary outcome was ordinal analysis of modified Rankin Score at 90 days. The primary analysis included all patients in the 4 trials with 2 sensitivity analyses: (1) excluding patients in whom Solitaire was not the first device used and (2) including the 3 Solitaire-only trials (excluding ESCAPE). Secondary outcomes included functional independence (modified Rankin Score 0-2), symptomatic intracerebral hemorrhage, and mortality. The primary analysis included 787 patients: 401 randomized to endovascular thrombectomy and 386 to standard care, and 82.6% received intravenous thrombolysis. The common odds ratio for modified Rankin Score improvement was 2.7 (2.0-3.5) with no heterogeneity in effect by age, sex, baseline stroke severity, extent of computed tomography changes, site of occlusion, or pretreatment with alteplase. The number needed to treat to reduce disability was 2.5 and for an extra patient to achieve independent outcome was 4.25 (3.29-5.99). Successful revascularization occurred in 77% treated with Solitaire device. The rate of symptomatic intracerebral hemorrhage and overall mortality did not differ between treatment groups. Solitaire thrombectomy for large vessel ischemic stroke was safe and highly effective with substantially reduced disability. Benefits were consistent in all prespecified subgroups. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2 2016-01-01 2016 2016-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/185801 https://dx.doi.org/urn:doi:10.1161/STROKEAHA.115.012360 |
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https://ddd.uab.cat/record/185801 https://dx.doi.org/urn:doi:10.1161/STROKEAHA.115.012360 |
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Inglés eng |
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Inglés |
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eng |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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