Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?

OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper ai...

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Detalles Bibliográficos
Autores: Farré López, Núria, Farré, Ramon, Gozal, David
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/35640
Acceso en línea:http://hdl.handle.net/10230/35640
http://dx.doi.org/10.1016/j.chest.2018.03.001
Access Level:acceso abierto
Palabra clave:Son -- Aspectes fisiològics
Trastorns del son
Commentary
Intermittent hypoxia
Microbiome
Sleep apnea
Sleep fragmentation
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spelling Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?Farré López, NúriaFarré, RamonGozal, DavidSon -- Aspectes fisiològicsTrastorns del sonCommentaryIntermittent hypoxiaMicrobiomeSleep apneaSleep fragmentationOSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and it has been identified as playing significant roles in the development of host immunologic phenotypes. In humans and animal models, changes in gut microbial communities occur with lifestyle behaviors, such as smoking, long-distance travel, dietary preferences, physical exercise, and circadian rhythm disturbances. In parallel, diseases previously attributed in part to lifestyle such as obesity, coronary heart disease, depression, and asthma (also associated with OSA) are now claimed as microbiota related. We therefore posit that altered patterns of sleep and oxygenation, as seen in OSA, will promote specific alterations in gut microbiota that in turn will elicit the immunologic alterations that lead to OSA-induced end-organ morbidities. The present article assesses the potential mechanistic links between OSA-induced changes in gut microbiota and its morbid phenotypes.Elsevier20182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/35640http://dx.doi.org/10.1016/j.chest.2018.03.001reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésChest. 2018 Oct;154(4):754-9© Elsevier http://dx.doi.org/10.1016/j.chest.2018.03.001info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/356402026-06-12T07:21:37Z
dc.title.none.fl_str_mv Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
title Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
spellingShingle Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
Farré López, Núria
Son -- Aspectes fisiològics
Trastorns del son
Commentary
Intermittent hypoxia
Microbiome
Sleep apnea
Sleep fragmentation
title_short Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
title_full Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
title_fullStr Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
title_full_unstemmed Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
title_sort Sleep Apnea Morbidity: A Consequence of Microbial-Immune Cross-Talk?
dc.creator.none.fl_str_mv Farré López, Núria
Farré, Ramon
Gozal, David
author Farré López, Núria
author_facet Farré López, Núria
Farré, Ramon
Gozal, David
author_role author
author2 Farré, Ramon
Gozal, David
author2_role author
author
dc.subject.none.fl_str_mv Son -- Aspectes fisiològics
Trastorns del son
Commentary
Intermittent hypoxia
Microbiome
Sleep apnea
Sleep fragmentation
topic Son -- Aspectes fisiològics
Trastorns del son
Commentary
Intermittent hypoxia
Microbiome
Sleep apnea
Sleep fragmentation
description OSA has emerged as a highly prevalent public health problem that imposes important mid- and long-term consequences, namely cardiovascular, metabolic, cognitive, and cancer-related alterations. OSA is characterized by increased upper airway resistance, alveolar hypoventilation, and recurrent upper airway obstruction during sleep. Recurrent collapse of the upper airway develops with sleep onset and is associated with both intermittent hypoxemia and sleep fragmentation. The microbiome is a vast and complex polymicrobial ecosystem that coexists with the human organism, and it has been identified as playing significant roles in the development of host immunologic phenotypes. In humans and animal models, changes in gut microbial communities occur with lifestyle behaviors, such as smoking, long-distance travel, dietary preferences, physical exercise, and circadian rhythm disturbances. In parallel, diseases previously attributed in part to lifestyle such as obesity, coronary heart disease, depression, and asthma (also associated with OSA) are now claimed as microbiota related. We therefore posit that altered patterns of sleep and oxygenation, as seen in OSA, will promote specific alterations in gut microbiota that in turn will elicit the immunologic alterations that lead to OSA-induced end-organ morbidities. The present article assesses the potential mechanistic links between OSA-induced changes in gut microbiota and its morbid phenotypes.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/35640
http://dx.doi.org/10.1016/j.chest.2018.03.001
url http://hdl.handle.net/10230/35640
http://dx.doi.org/10.1016/j.chest.2018.03.001
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Chest. 2018 Oct;154(4):754-9
dc.rights.none.fl_str_mv © Elsevier http://dx.doi.org/10.1016/j.chest.2018.03.001
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Elsevier http://dx.doi.org/10.1016/j.chest.2018.03.001
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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