A deep learning model for prognosis prediction after intracranial hemorrhage

Background and Purpose Intracranial hemorrhage (ICH) is a common life-threatening condition that must be rapidly diagnosed and treated. However, there is still a lack of consensus regarding treatment, driven to some extent by prognostic uncertainty. While several prediction models for ICH detection...

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Bibliographic Details
Authors: Pérez del Barrio, Amaia, Esteve Domínguez, Anna Salut, Menéndez Fernández-Miranda, Pablo, Sanz Bellón, Pablo, Rodríguez González, David|||0000-0002-9160-5106, Lloret Iglesias, Lara, Marqués Fraguela, Enrique, González Mandly, Andrés Antonio, Vega, José A.
Format: article
Publication Date:2023
Country:España
Institution:Universidad de Cantabria (UC)
Repository:UCrea Repositorio Abierto de la Universidad de Cantabria
Language:English
OAI Identifier:oai:repositorio.unican.es:10902/29988
Online Access:https://hdl.handle.net/10902/29988
Access Level:Open access
Keyword:Deep learning
Head CT
Hybrid
Intracranial hemorrhage
Medical image
Prediction
Prognosis
Description
Summary:Background and Purpose Intracranial hemorrhage (ICH) is a common life-threatening condition that must be rapidly diagnosed and treated. However, there is still a lack of consensus regarding treatment, driven to some extent by prognostic uncertainty. While several prediction models for ICH detection have already been published, here we present a deep learning predictive model for ICH prognosis. Methods We included patients with ICH (n = 262), and we trained a custom model for the classification of patients into poor prognosis and good prognosis, using a hybrid input consisting of brain CT images and other clinical variables. We compared it with two other models, one trained with images only (I-model) and the other with tabular data only (D-model). Results Our hybrid model achieved an area under the receiver operating characteristic curve (AUC) of .924 (95% confidence interval [CI]: .831-.986), and an accuracy of .861 (95% CI: .760-.960). The I- and D-models achieved an AUC of .763 (95% CI: .622-.902) and .746 (95% CI: .598-.876), respectively. Conclusions The proposed hybrid model was able to accurately classify patients into good and poor prognosis. To the best of our knowledge, this is the first ICH prognosis prediction deep learning model. We concluded that deep learning can be applied for prognosis prediction in ICH that could have a great impact on clinical decision-making. Further, hybrid inputs could be a promising technique for deep learning in medical imaging.