Determination of Interactive States of Immune Checkpoint Regulators in Lung Metastases after Radiofrequency Ablation

[Background] Cases of the spontaneous regression of multiple pulmonary metastases, after radiofrequency ablation (RFA), of a single lung metastasis, have been documented to be mediated by the immune system. The interaction of immune checkpoints, e.g., PD-1/PD-L1 and CTLA-4/CD80, may explain this phe...

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Detalhes bibliográficos
Autores: Miles, James, Soubeyran, Isabelle, Marliot, Florence, Pangon, Nicolas, Italiano, Antoine, Bellera, Carine, Ward, Stephen G., Pagès, Franck, Palussière, Jean, Larijani, Banafshé
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/296791
Acesso em linha:http://hdl.handle.net/10261/296791
Access Level:acceso abierto
Palavra-chave:Immune checkpoints
PD-1/PD-L1
CTLA-4/CD80
Radiofrequency ablation
Abscopal effect
FRET/FLIM
Immune surveyance
Descrição
Resumo:[Background] Cases of the spontaneous regression of multiple pulmonary metastases, after radiofrequency ablation (RFA), of a single lung metastasis, have been documented to be mediated by the immune system. The interaction of immune checkpoints, e.g., PD-1/PD-L1 and CTLA-4/CD80, may explain this phenomenon. The purpose of this study is to identify and quantify immune mechanisms triggered by RFA of pulmonary metastases originating from colorectal cancer.

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