Microalgae as a new source of chitosans
[eng] Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the development of products taking advantage of these bioactivities has lagged be...
| Autor: | |
|---|---|
| Tipo de recurso: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/109498 |
| Acceso en línea: | https://hdl.handle.net/2445/109498 http://hdl.handle.net/10803/402113 |
| Access Level: | acceso abierto |
| Palabra clave: | Microalgues Quitosan Polisacàrids Microalgae Chitosan Polysaccharides |
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Microalgae as a new source of chitosansLatil de Ros, DerekMicroalguesQuitosanPolisacàridsMicroalgaeChitosanPolysaccharides[eng] Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the development of products taking advantage of these bioactivities has lagged behind expectations. The historic main reason is the poor reproducibility of the biological effects of chitosans due to a harsh chemical deacetylation process that impairs the structure of the polysaccharides inducing variability. Another reason is the immunologic responses that these polymers may produce in the presence of traces of crustacean proteins. It is therefore necessary to gather chitosans from other non-animal sources using a more environmentally friendly and reproducible process. Publications have commented that some microalgae species might contain chitin and even chitosan in their cell walls. Hence, in order to confirm these hypotheses, a screening method has been developed to detect each of these polymers specifically amongst the wide diversity of microalgae species of Greenaltech’s library. Thanks to this screening method, natural chitins and chitosans have been found in several genera. The methodology has been validated with the extraction and physicochemical characterization of chitins and chitosans from Chlorella, something that, to our knowledge, had never been done before. At the same time, the enzymatic deacetylation process behind the natural production of chitosan in Chlorella has been studied emphasizing the identification of active chitin deacetylases. Finally, as part of an exploratory biofunctional study of microalgal chitosans, the antimicrobial, wound healing and nanocapsule-forming properties have been analyzed.Universitat de BarcelonaMercade Roca, JaumeBadía Palacín, JosefaUniversitat de Barcelona. Facultat de Farmàcia2017info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/109498http://hdl.handle.net/10803/402113Tesis Doctorals - Facultat - Farmàciareponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglés(c) Latil, 2017info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1094982026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Microalgae as a new source of chitosans |
| title |
Microalgae as a new source of chitosans |
| spellingShingle |
Microalgae as a new source of chitosans Latil de Ros, Derek Microalgues Quitosan Polisacàrids Microalgae Chitosan Polysaccharides |
| title_short |
Microalgae as a new source of chitosans |
| title_full |
Microalgae as a new source of chitosans |
| title_fullStr |
Microalgae as a new source of chitosans |
| title_full_unstemmed |
Microalgae as a new source of chitosans |
| title_sort |
Microalgae as a new source of chitosans |
| dc.creator.none.fl_str_mv |
Latil de Ros, Derek |
| author |
Latil de Ros, Derek |
| author_facet |
Latil de Ros, Derek |
| author_role |
author |
| dc.contributor.none.fl_str_mv |
Mercade Roca, Jaume Badía Palacín, Josefa Universitat de Barcelona. Facultat de Farmàcia |
| dc.subject.none.fl_str_mv |
Microalgues Quitosan Polisacàrids Microalgae Chitosan Polysaccharides |
| topic |
Microalgues Quitosan Polisacàrids Microalgae Chitosan Polysaccharides |
| description |
[eng] Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the development of products taking advantage of these bioactivities has lagged behind expectations. The historic main reason is the poor reproducibility of the biological effects of chitosans due to a harsh chemical deacetylation process that impairs the structure of the polysaccharides inducing variability. Another reason is the immunologic responses that these polymers may produce in the presence of traces of crustacean proteins. It is therefore necessary to gather chitosans from other non-animal sources using a more environmentally friendly and reproducible process. Publications have commented that some microalgae species might contain chitin and even chitosan in their cell walls. Hence, in order to confirm these hypotheses, a screening method has been developed to detect each of these polymers specifically amongst the wide diversity of microalgae species of Greenaltech’s library. Thanks to this screening method, natural chitins and chitosans have been found in several genera. The methodology has been validated with the extraction and physicochemical characterization of chitins and chitosans from Chlorella, something that, to our knowledge, had never been done before. At the same time, the enzymatic deacetylation process behind the natural production of chitosan in Chlorella has been studied emphasizing the identification of active chitin deacetylases. Finally, as part of an exploratory biofunctional study of microalgal chitosans, the antimicrobial, wound healing and nanocapsule-forming properties have been analyzed. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 |
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info:eu-repo/semantics/doctoralThesis info:eu-repo/semantics/publishedVersion |
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doctoralThesis |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/109498 http://hdl.handle.net/10803/402113 |
| url |
https://hdl.handle.net/2445/109498 http://hdl.handle.net/10803/402113 |
| dc.language.none.fl_str_mv |
Inglés |
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Inglés |
| dc.rights.none.fl_str_mv |
(c) Latil, 2017 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
(c) Latil, 2017 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universitat de Barcelona |
| publisher.none.fl_str_mv |
Universitat de Barcelona |
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Tesis Doctorals - Facultat - Farmàcia reponame:Dipòsit Digital de la UB instname:Universidad de Barcelona |
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Universidad de Barcelona |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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1869419897942966272 |
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15.301603 |