Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts
Background The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations. Methods We identified 48 612 individuals aged 20–40 years across eight p...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universidad de Oviedo (UNIOVI) |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/227551 |
| Acceso en línea: | https://hdl.handle.net/2445/227551 |
| Access Level: | acceso abierto |
| Palabra clave: | Malalties de l'aparell respiratori Malalties pulmonars obstructives cròniques Insuficiència respiratòria Respiratory diseases Chronic obstructive pulmonary diseases Respiratory insufficiency |
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Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohortsÇolak, YunusAllinson, James P.Berge, Maarten van denJarvis, DebbieLanghammer, ArnulfBreyer-Kohansal, RobabNwaru, Bright I.Backman, HelenaVonk, Judith M.Nordestgaard, Børge G.Lange, PeterAalberg Vikjord, Sigrid AnnaBreyer, Marie KathrinKankaanranta, HannuLindberg, AnneRönmark, EvaVanfleteren, Lowie E. G. W.Vestbo, JørgenWedzicha, Jadwiga A.Melén, ErikAgustí García-Navarro, ÀlvarFaner, RosaAfzal, ShoaibCADSET ERS Clinical Research CollaborationMalalties de l'aparell respiratoriMalalties pulmonars obstructives cròniquesInsuficiència respiratòriaRespiratory diseasesChronic obstructive pulmonary diseasesRespiratory insufficiencyBackground The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations. Methods We identified 48 612 individuals aged 20–40 years across eight population-based European cohorts in the Chronic Airway Diseases Early Stratification (CADSET) collaboration and applied two commonly used definitions of airflow obstruction: pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.70 and below the lower limit of normal (LLN). We explored how the prevalence of airflow obstruction according to both criteria was related to age, sex and smoking. Results Airflow obstruction prevalence increased with increasing age from 2.3% in those aged 20–24.9 years to 6.3% in those aged 35–39.9 years according to FEV1/FVC <0.70, and from 7.3% to 8.3% according to FEV1/FVC <LLN. The corresponding increase in airflow obstruction prevalence was up to 8.8% in males versus 7.5% in females, and up to 9.0% in ever-smokers versus 6.9% in never-smokers. Difference in prevalence of airflow obstruction between FEV1/FVC <0.70 and <LLN was highest for females and ever-smokers. Active smoking ranged from 19% to 28% and ever-smoking from 37% to 51%. The prevalence of airflow obstruction increased with pack-years, plateauing at ∼5 pack-years. Conclusion Up to 8% of young adults across Europe have airflow obstruction; its cause and its role in prior, concurrent and future airway disease merit further investigation.European Respiratory Society2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/227551Articles publicats en revistes (Biomedicina)reponame:Dipòsit Digital de la UBinstname:Universidad de Oviedo (UNIOVI)InglésReproducció del document publicat a: https://doi.org/10.1183/23120541.00233-2025ERJ Open Research, 2025, vol. 11, num.6https://doi.org/10.1183/23120541.00233-2025cc-by-nc (c) Çolak, Yunus et al., 2025http://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2275512026-05-27T06:46:51Z |
| dc.title.none.fl_str_mv |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| title |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| spellingShingle |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts Çolak, Yunus Malalties de l'aparell respiratori Malalties pulmonars obstructives cròniques Insuficiència respiratòria Respiratory diseases Chronic obstructive pulmonary diseases Respiratory insufficiency |
| title_short |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| title_full |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| title_fullStr |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| title_full_unstemmed |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| title_sort |
Airflow obstruction among young adults in Europe: a Chronic Airway Diseases Early Stratification (CADSET) collaboration with 48 612 individuals across eight population-based cohorts |
| dc.creator.none.fl_str_mv |
Çolak, Yunus Allinson, James P. Berge, Maarten van den Jarvis, Debbie Langhammer, Arnulf Breyer-Kohansal, Robab Nwaru, Bright I. Backman, Helena Vonk, Judith M. Nordestgaard, Børge G. Lange, Peter Aalberg Vikjord, Sigrid Anna Breyer, Marie Kathrin Kankaanranta, Hannu Lindberg, Anne Rönmark, Eva Vanfleteren, Lowie E. G. W. Vestbo, Jørgen Wedzicha, Jadwiga A. Melén, Erik Agustí García-Navarro, Àlvar Faner, Rosa Afzal, Shoaib CADSET ERS Clinical Research Collaboration |
| author |
Çolak, Yunus |
| author_facet |
Çolak, Yunus Allinson, James P. Berge, Maarten van den Jarvis, Debbie Langhammer, Arnulf Breyer-Kohansal, Robab Nwaru, Bright I. Backman, Helena Vonk, Judith M. Nordestgaard, Børge G. Lange, Peter Aalberg Vikjord, Sigrid Anna Breyer, Marie Kathrin Kankaanranta, Hannu Lindberg, Anne Rönmark, Eva Vanfleteren, Lowie E. G. W. Vestbo, Jørgen Wedzicha, Jadwiga A. Melén, Erik Agustí García-Navarro, Àlvar Faner, Rosa Afzal, Shoaib CADSET ERS Clinical Research Collaboration |
| author_role |
author |
| author2 |
Allinson, James P. Berge, Maarten van den Jarvis, Debbie Langhammer, Arnulf Breyer-Kohansal, Robab Nwaru, Bright I. Backman, Helena Vonk, Judith M. Nordestgaard, Børge G. Lange, Peter Aalberg Vikjord, Sigrid Anna Breyer, Marie Kathrin Kankaanranta, Hannu Lindberg, Anne Rönmark, Eva Vanfleteren, Lowie E. G. W. Vestbo, Jørgen Wedzicha, Jadwiga A. Melén, Erik Agustí García-Navarro, Àlvar Faner, Rosa Afzal, Shoaib CADSET ERS Clinical Research Collaboration |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Malalties de l'aparell respiratori Malalties pulmonars obstructives cròniques Insuficiència respiratòria Respiratory diseases Chronic obstructive pulmonary diseases Respiratory insufficiency |
| topic |
Malalties de l'aparell respiratori Malalties pulmonars obstructives cròniques Insuficiència respiratòria Respiratory diseases Chronic obstructive pulmonary diseases Respiratory insufficiency |
| description |
Background The extent to which airflow obstruction, a key feature of COPD, can be already present in early adulthood is unclear. We investigated the prevalence of airflow obstruction in young adults across European populations. Methods We identified 48 612 individuals aged 20–40 years across eight population-based European cohorts in the Chronic Airway Diseases Early Stratification (CADSET) collaboration and applied two commonly used definitions of airflow obstruction: pre-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) <0.70 and below the lower limit of normal (LLN). We explored how the prevalence of airflow obstruction according to both criteria was related to age, sex and smoking. Results Airflow obstruction prevalence increased with increasing age from 2.3% in those aged 20–24.9 years to 6.3% in those aged 35–39.9 years according to FEV1/FVC <0.70, and from 7.3% to 8.3% according to FEV1/FVC <LLN. The corresponding increase in airflow obstruction prevalence was up to 8.8% in males versus 7.5% in females, and up to 9.0% in ever-smokers versus 6.9% in never-smokers. Difference in prevalence of airflow obstruction between FEV1/FVC <0.70 and <LLN was highest for females and ever-smokers. Active smoking ranged from 19% to 28% and ever-smoking from 37% to 51%. The prevalence of airflow obstruction increased with pack-years, plateauing at ∼5 pack-years. Conclusion Up to 8% of young adults across Europe have airflow obstruction; its cause and its role in prior, concurrent and future airway disease merit further investigation. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/227551 |
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https://hdl.handle.net/2445/227551 |
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Inglés |
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Inglés |
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Reproducció del document publicat a: https://doi.org/10.1183/23120541.00233-2025 ERJ Open Research, 2025, vol. 11, num.6 https://doi.org/10.1183/23120541.00233-2025 |
| dc.rights.none.fl_str_mv |
cc-by-nc (c) Çolak, Yunus et al., 2025 http://creativecommons.org/licenses/by-nc/4.0/ info:eu-repo/semantics/openAccess |
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cc-by-nc (c) Çolak, Yunus et al., 2025 http://creativecommons.org/licenses/by-nc/4.0/ |
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openAccess |
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application/pdf |
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European Respiratory Society |
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European Respiratory Society |
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Articles publicats en revistes (Biomedicina) reponame:Dipòsit Digital de la UB instname:Universidad de Oviedo (UNIOVI) |
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Universidad de Oviedo (UNIOVI) |
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Dipòsit Digital de la UB |
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Dipòsit Digital de la UB |
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