An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group

Boedhoe, Premika; Heymans, Martijn W.; Schmaal, Lianne|||0000-0001-9822-048X; Abe, Yoshinari|||0000-0001-8348-0801; Alonso, Pino|||0000-0002-5779-9111; Ameis, Stephanie H.|||0000-0002-7282-6077; Anticevic, Alan; Arnold, Paul D.|||0000-0003-2496-4624; Batistuzzo, Marcelo C.|||0000-0003-1347-8241; Benedetti, Francesco|||0000-0003-4949-856X; Beucke, Jan C.; Bollettini, Irene|||0000-0003-3666-3538; Bose, Anushree|||0000-0002-3394-1646; Brem, Silvia; Calvo, Anna; Calvo-Escalona, Rosa|||0000-0001-9572-4228; Cheng, Yuqi; Cho, Kang Ik K.; Ciullo, Valentina|||0000-0002-4095-7806; Dallaspezia, Sara; Denys, Damiaan|||0000-0002-3191-3844; Feusner, Jamie D.; Fitzgerald, Kate D.; Fouche, Jean-Paul|||0000-0002-0830-2324; Fridgeirsson, Egill A.; Gruner, Patricia; Hanna, Gregory L.|||0000-0002-0742-6990; Hibar, Derrek P.; Hoexter, Marcelo Q.; Hu, Hao; Huyser, Chaim|||0000-0001-8757-3124; Jahanshad, Neda|||0000-0003-4401-8950; James, Anthony|||0000-0002-2742-8328; Kathmann, Norbert|||0000-0002-1348-7060; Kaufmann, Christian; Koch, Kathrin; Kwon, Jun Soo|||0000-0002-1060-1462; Lázaro, Luisa|||0000-0002-8425-5750; Lochner, Christine|||0000-0002-4766-3704; Marsh, Rachel|||0000-0003-2439-6305; Martínez-Zalacaín, Ignacio|||0000-0002-4036-0284; Mataix-Cols, David|||0000-0002-4545-0924; Menchón Magriñá, José Manuel|||0000-0002-6231-6524; Minuzzi, Luciano; Morer, Astrid; Nakamae, Takashi|||0000-0003-4265-198X; Nakao, Tomohiro; Narayanaswamy, Janardhanan C.; Nishida, Seiji; Nurmi, Erika L.|||0000-0003-4893-8957; O'Neill, Joseph; Piacentini, John|||0000-0003-4195-7194; Piras, Fabrizio|||0000-0003-3566-5494; Piras, Federica|||0000-0002-9546-7038; Reddy, Y. C. Janardhan; Reess, Tim J.; Sakai, Yuki|||0000-0003-2475-8548; Sato, Joao R.; Simpson, H. Blair; Soreni, Noam; Soriano-Mas, Carles|||0000-0003-4574-6597; Spalletta, Gianfranco|||0000-0002-7432-4249; Stevens, Michael C.|||0000-0002-3799-5465; Szeszko, Philip R.; Tolin, David F.; van Wingen, Guido|||0000-0003-3076-5891; Venkatasubramanian, Ganesan|||0000-0002-0949-898X; Walitza, Susanne|||0000-0002-8161-8683; Wang, Zhen|||0000-0003-4319-5314; Yun, Je-Yeon|||0000-0002-5531-2410; Thompson, Paul M.|||0000-0002-4720-8867; Stein, Dan J.|||0000-0001-7218-7810; van den Heuvel, Odile A.|||0000-0002-9804-7653; Twisk, Jos W. R.

An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group

Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage agg...

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Autores:	Boedhoe, Premika, Heymans, Martijn W., Schmaal, Lianne\|\|\|0000-0001-9822-048X, Abe, Yoshinari\|\|\|0000-0001-8348-0801, Alonso, Pino\|\|\|0000-0002-5779-9111, Ameis, Stephanie H.\|\|\|0000-0002-7282-6077, Anticevic, Alan, Arnold, Paul D.\|\|\|0000-0003-2496-4624, Batistuzzo, Marcelo C.\|\|\|0000-0003-1347-8241, Benedetti, Francesco\|\|\|0000-0003-4949-856X, Beucke, Jan C., Bollettini, Irene\|\|\|0000-0003-3666-3538, Bose, Anushree\|\|\|0000-0002-3394-1646, Brem, Silvia, Calvo, Anna, Calvo-Escalona, Rosa\|\|\|0000-0001-9572-4228, Cheng, Yuqi, Cho, Kang Ik K., Ciullo, Valentina\|\|\|0000-0002-4095-7806, Dallaspezia, Sara, Denys, Damiaan\|\|\|0000-0002-3191-3844, Feusner, Jamie D., Fitzgerald, Kate D., Fouche, Jean-Paul\|\|\|0000-0002-0830-2324, Fridgeirsson, Egill A., Gruner, Patricia, Hanna, Gregory L.\|\|\|0000-0002-0742-6990, Hibar, Derrek P., Hoexter, Marcelo Q., Hu, Hao, Huyser, Chaim\|\|\|0000-0001-8757-3124, Jahanshad, Neda\|\|\|0000-0003-4401-8950, James, Anthony\|\|\|0000-0002-2742-8328, Kathmann, Norbert\|\|\|0000-0002-1348-7060, Kaufmann, Christian, Koch, Kathrin, Kwon, Jun Soo\|\|\|0000-0002-1060-1462, Lázaro, Luisa\|\|\|0000-0002-8425-5750, Lochner, Christine\|\|\|0000-0002-4766-3704, Marsh, Rachel\|\|\|0000-0003-2439-6305, Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284, Mataix-Cols, David\|\|\|0000-0002-4545-0924, Menchón Magriñá, José Manuel\|\|\|0000-0002-6231-6524, Minuzzi, Luciano, Morer, Astrid, Nakamae, Takashi\|\|\|0000-0003-4265-198X, Nakao, Tomohiro, Narayanaswamy, Janardhanan C., Nishida, Seiji, Nurmi, Erika L.\|\|\|0000-0003-4893-8957, O'Neill, Joseph, Piacentini, John\|\|\|0000-0003-4195-7194, Piras, Fabrizio\|\|\|0000-0003-3566-5494, Piras, Federica\|\|\|0000-0002-9546-7038, Reddy, Y. C. Janardhan, Reess, Tim J., Sakai, Yuki\|\|\|0000-0003-2475-8548, Sato, Joao R., Simpson, H. Blair, Soreni, Noam, Soriano-Mas, Carles\|\|\|0000-0003-4574-6597, Spalletta, Gianfranco\|\|\|0000-0002-7432-4249, Stevens, Michael C.\|\|\|0000-0002-3799-5465, Szeszko, Philip R., Tolin, David F., van Wingen, Guido\|\|\|0000-0003-3076-5891, Venkatasubramanian, Ganesan\|\|\|0000-0002-0949-898X, Walitza, Susanne\|\|\|0000-0002-8161-8683, Wang, Zhen\|\|\|0000-0003-4319-5314, Yun, Je-Yeon\|\|\|0000-0002-5531-2410, Thompson, Paul M.\|\|\|0000-0002-4720-8867, Stein, Dan J.\|\|\|0000-0001-7218-7810, van den Heuvel, Odile A.\|\|\|0000-0002-9804-7653, Twisk, Jos W. R.
Tipo de recurso:	artículo
Fecha de publicación:	2019
País:	España
Institución:	Universitat Autònoma de Barcelona
Repositorio:	Dipòsit Digital de Documents de la UAB
Idioma:	inglés
OAI Identifier:	oai:ddd.uab.cat:226321
Acceso en línea:	https://ddd.uab.cat/record/226321 https://dx.doi.org/urn:doi:10.3389/fninf.2018.00102
Access Level:	acceso abierto
Palabra clave:	Neuroimaging MRI IPD meta-analysis Mega-analysis Linear mixed-effect models

id	ES_cddd983906ee31a311a26e68da997af6
oai_identifier_str	oai:ddd.uab.cat:226321
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
title	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
spellingShingle	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group Boedhoe, Premika Neuroimaging MRI IPD meta-analysis Mega-analysis Linear mixed-effect models
title_short	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
title_full	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
title_fullStr	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
title_full_unstemmed	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
title_sort	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group
dc.creator.none.fl_str_mv	Boedhoe, Premika Heymans, Martijn W. Schmaal, Lianne\|\|\|0000-0001-9822-048X Abe, Yoshinari\|\|\|0000-0001-8348-0801 Alonso, Pino\|\|\|0000-0002-5779-9111 Ameis, Stephanie H.\|\|\|0000-0002-7282-6077 Anticevic, Alan Arnold, Paul D.\|\|\|0000-0003-2496-4624 Batistuzzo, Marcelo C.\|\|\|0000-0003-1347-8241 Benedetti, Francesco\|\|\|0000-0003-4949-856X Beucke, Jan C. Bollettini, Irene\|\|\|0000-0003-3666-3538 Bose, Anushree\|\|\|0000-0002-3394-1646 Brem, Silvia Calvo, Anna Calvo-Escalona, Rosa\|\|\|0000-0001-9572-4228 Cheng, Yuqi Cho, Kang Ik K. Ciullo, Valentina\|\|\|0000-0002-4095-7806 Dallaspezia, Sara Denys, Damiaan\|\|\|0000-0002-3191-3844 Feusner, Jamie D. Fitzgerald, Kate D. Fouche, Jean-Paul\|\|\|0000-0002-0830-2324 Fridgeirsson, Egill A. Gruner, Patricia Hanna, Gregory L.\|\|\|0000-0002-0742-6990 Hibar, Derrek P. Hoexter, Marcelo Q. Hu, Hao Huyser, Chaim\|\|\|0000-0001-8757-3124 Jahanshad, Neda\|\|\|0000-0003-4401-8950 James, Anthony\|\|\|0000-0002-2742-8328 Kathmann, Norbert\|\|\|0000-0002-1348-7060 Kaufmann, Christian Koch, Kathrin Kwon, Jun Soo\|\|\|0000-0002-1060-1462 Lázaro, Luisa\|\|\|0000-0002-8425-5750 Lochner, Christine\|\|\|0000-0002-4766-3704 Marsh, Rachel\|\|\|0000-0003-2439-6305 Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mataix-Cols, David\|\|\|0000-0002-4545-0924 Menchón Magriñá, José Manuel\|\|\|0000-0002-6231-6524 Minuzzi, Luciano Morer, Astrid Nakamae, Takashi\|\|\|0000-0003-4265-198X Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nishida, Seiji Nurmi, Erika L.\|\|\|0000-0003-4893-8957 O'Neill, Joseph Piacentini, John\|\|\|0000-0003-4195-7194 Piras, Fabrizio\|\|\|0000-0003-3566-5494 Piras, Federica\|\|\|0000-0002-9546-7038 Reddy, Y. C. Janardhan Reess, Tim J. Sakai, Yuki\|\|\|0000-0003-2475-8548 Sato, Joao R. Simpson, H. Blair Soreni, Noam Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Spalletta, Gianfranco\|\|\|0000-0002-7432-4249 Stevens, Michael C.\|\|\|0000-0002-3799-5465 Szeszko, Philip R. Tolin, David F. van Wingen, Guido\|\|\|0000-0003-3076-5891 Venkatasubramanian, Ganesan\|\|\|0000-0002-0949-898X Walitza, Susanne\|\|\|0000-0002-8161-8683 Wang, Zhen\|\|\|0000-0003-4319-5314 Yun, Je-Yeon\|\|\|0000-0002-5531-2410 Thompson, Paul M.\|\|\|0000-0002-4720-8867 Stein, Dan J.\|\|\|0000-0001-7218-7810 van den Heuvel, Odile A.\|\|\|0000-0002-9804-7653 Twisk, Jos W. R.
author	Boedhoe, Premika
author_facet	Boedhoe, Premika Heymans, Martijn W. Schmaal, Lianne\|\|\|0000-0001-9822-048X Abe, Yoshinari\|\|\|0000-0001-8348-0801 Alonso, Pino\|\|\|0000-0002-5779-9111 Ameis, Stephanie H.\|\|\|0000-0002-7282-6077 Anticevic, Alan Arnold, Paul D.\|\|\|0000-0003-2496-4624 Batistuzzo, Marcelo C.\|\|\|0000-0003-1347-8241 Benedetti, Francesco\|\|\|0000-0003-4949-856X Beucke, Jan C. Bollettini, Irene\|\|\|0000-0003-3666-3538 Bose, Anushree\|\|\|0000-0002-3394-1646 Brem, Silvia Calvo, Anna Calvo-Escalona, Rosa\|\|\|0000-0001-9572-4228 Cheng, Yuqi Cho, Kang Ik K. Ciullo, Valentina\|\|\|0000-0002-4095-7806 Dallaspezia, Sara Denys, Damiaan\|\|\|0000-0002-3191-3844 Feusner, Jamie D. Fitzgerald, Kate D. Fouche, Jean-Paul\|\|\|0000-0002-0830-2324 Fridgeirsson, Egill A. Gruner, Patricia Hanna, Gregory L.\|\|\|0000-0002-0742-6990 Hibar, Derrek P. Hoexter, Marcelo Q. Hu, Hao Huyser, Chaim\|\|\|0000-0001-8757-3124 Jahanshad, Neda\|\|\|0000-0003-4401-8950 James, Anthony\|\|\|0000-0002-2742-8328 Kathmann, Norbert\|\|\|0000-0002-1348-7060 Kaufmann, Christian Koch, Kathrin Kwon, Jun Soo\|\|\|0000-0002-1060-1462 Lázaro, Luisa\|\|\|0000-0002-8425-5750 Lochner, Christine\|\|\|0000-0002-4766-3704 Marsh, Rachel\|\|\|0000-0003-2439-6305 Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mataix-Cols, David\|\|\|0000-0002-4545-0924 Menchón Magriñá, José Manuel\|\|\|0000-0002-6231-6524 Minuzzi, Luciano Morer, Astrid Nakamae, Takashi\|\|\|0000-0003-4265-198X Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nishida, Seiji Nurmi, Erika L.\|\|\|0000-0003-4893-8957 O'Neill, Joseph Piacentini, John\|\|\|0000-0003-4195-7194 Piras, Fabrizio\|\|\|0000-0003-3566-5494 Piras, Federica\|\|\|0000-0002-9546-7038 Reddy, Y. C. Janardhan Reess, Tim J. Sakai, Yuki\|\|\|0000-0003-2475-8548 Sato, Joao R. Simpson, H. Blair Soreni, Noam Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Spalletta, Gianfranco\|\|\|0000-0002-7432-4249 Stevens, Michael C.\|\|\|0000-0002-3799-5465 Szeszko, Philip R. Tolin, David F. van Wingen, Guido\|\|\|0000-0003-3076-5891 Venkatasubramanian, Ganesan\|\|\|0000-0002-0949-898X Walitza, Susanne\|\|\|0000-0002-8161-8683 Wang, Zhen\|\|\|0000-0003-4319-5314 Yun, Je-Yeon\|\|\|0000-0002-5531-2410 Thompson, Paul M.\|\|\|0000-0002-4720-8867 Stein, Dan J.\|\|\|0000-0001-7218-7810 van den Heuvel, Odile A.\|\|\|0000-0002-9804-7653 Twisk, Jos W. R.
author_role	author
author2	Heymans, Martijn W. Schmaal, Lianne\|\|\|0000-0001-9822-048X Abe, Yoshinari\|\|\|0000-0001-8348-0801 Alonso, Pino\|\|\|0000-0002-5779-9111 Ameis, Stephanie H.\|\|\|0000-0002-7282-6077 Anticevic, Alan Arnold, Paul D.\|\|\|0000-0003-2496-4624 Batistuzzo, Marcelo C.\|\|\|0000-0003-1347-8241 Benedetti, Francesco\|\|\|0000-0003-4949-856X Beucke, Jan C. Bollettini, Irene\|\|\|0000-0003-3666-3538 Bose, Anushree\|\|\|0000-0002-3394-1646 Brem, Silvia Calvo, Anna Calvo-Escalona, Rosa\|\|\|0000-0001-9572-4228 Cheng, Yuqi Cho, Kang Ik K. Ciullo, Valentina\|\|\|0000-0002-4095-7806 Dallaspezia, Sara Denys, Damiaan\|\|\|0000-0002-3191-3844 Feusner, Jamie D. Fitzgerald, Kate D. Fouche, Jean-Paul\|\|\|0000-0002-0830-2324 Fridgeirsson, Egill A. Gruner, Patricia Hanna, Gregory L.\|\|\|0000-0002-0742-6990 Hibar, Derrek P. Hoexter, Marcelo Q. Hu, Hao Huyser, Chaim\|\|\|0000-0001-8757-3124 Jahanshad, Neda\|\|\|0000-0003-4401-8950 James, Anthony\|\|\|0000-0002-2742-8328 Kathmann, Norbert\|\|\|0000-0002-1348-7060 Kaufmann, Christian Koch, Kathrin Kwon, Jun Soo\|\|\|0000-0002-1060-1462 Lázaro, Luisa\|\|\|0000-0002-8425-5750 Lochner, Christine\|\|\|0000-0002-4766-3704 Marsh, Rachel\|\|\|0000-0003-2439-6305 Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284 Mataix-Cols, David\|\|\|0000-0002-4545-0924 Menchón Magriñá, José Manuel\|\|\|0000-0002-6231-6524 Minuzzi, Luciano Morer, Astrid Nakamae, Takashi\|\|\|0000-0003-4265-198X Nakao, Tomohiro Narayanaswamy, Janardhanan C. Nishida, Seiji Nurmi, Erika L.\|\|\|0000-0003-4893-8957 O'Neill, Joseph Piacentini, John\|\|\|0000-0003-4195-7194 Piras, Fabrizio\|\|\|0000-0003-3566-5494 Piras, Federica\|\|\|0000-0002-9546-7038 Reddy, Y. C. Janardhan Reess, Tim J. Sakai, Yuki\|\|\|0000-0003-2475-8548 Sato, Joao R. Simpson, H. Blair Soreni, Noam Soriano-Mas, Carles\|\|\|0000-0003-4574-6597 Spalletta, Gianfranco\|\|\|0000-0002-7432-4249 Stevens, Michael C.\|\|\|0000-0002-3799-5465 Szeszko, Philip R. Tolin, David F. van Wingen, Guido\|\|\|0000-0003-3076-5891 Venkatasubramanian, Ganesan\|\|\|0000-0002-0949-898X Walitza, Susanne\|\|\|0000-0002-8161-8683 Wang, Zhen\|\|\|0000-0003-4319-5314 Yun, Je-Yeon\|\|\|0000-0002-5531-2410 Thompson, Paul M.\|\|\|0000-0002-4720-8867 Stein, Dan J.\|\|\|0000-0001-7218-7810 van den Heuvel, Odile A.\|\|\|0000-0002-9804-7653 Twisk, Jos W. R.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	Neuroimaging MRI IPD meta-analysis Mega-analysis Linear mixed-effect models
topic	Neuroimaging MRI IPD meta-analysis Mega-analysis Linear mixed-effect models
description	Objective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data
publishDate	2019
dc.date.none.fl_str_mv	2 2019-01-01 2019 2019-01-01
dc.type.none.fl_str_mv	Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	https://ddd.uab.cat/record/226321 https://dx.doi.org/urn:doi:10.3389/fninf.2018.00102
url	https://ddd.uab.cat/record/226321 https://dx.doi.org/urn:doi:10.3389/fninf.2018.00102
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1247 Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-489
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.source.none.fl_str_mv	reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona
instname_str	Universitat Autònoma de Barcelona
reponame_str	Dipòsit Digital de Documents de la UAB
collection	Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling	An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working groupBoedhoe, PremikaHeymans, Martijn W.Schmaal, Lianne\|\|\|0000-0001-9822-048XAbe, Yoshinari\|\|\|0000-0001-8348-0801Alonso, Pino\|\|\|0000-0002-5779-9111Ameis, Stephanie H.\|\|\|0000-0002-7282-6077Anticevic, AlanArnold, Paul D.\|\|\|0000-0003-2496-4624Batistuzzo, Marcelo C.\|\|\|0000-0003-1347-8241Benedetti, Francesco\|\|\|0000-0003-4949-856XBeucke, Jan C.Bollettini, Irene\|\|\|0000-0003-3666-3538Bose, Anushree\|\|\|0000-0002-3394-1646Brem, SilviaCalvo, AnnaCalvo-Escalona, Rosa\|\|\|0000-0001-9572-4228Cheng, YuqiCho, Kang Ik K.Ciullo, Valentina\|\|\|0000-0002-4095-7806Dallaspezia, SaraDenys, Damiaan\|\|\|0000-0002-3191-3844Feusner, Jamie D.Fitzgerald, Kate D.Fouche, Jean-Paul\|\|\|0000-0002-0830-2324Fridgeirsson, Egill A.Gruner, PatriciaHanna, Gregory L.\|\|\|0000-0002-0742-6990Hibar, Derrek P.Hoexter, Marcelo Q.Hu, HaoHuyser, Chaim\|\|\|0000-0001-8757-3124Jahanshad, Neda\|\|\|0000-0003-4401-8950James, Anthony\|\|\|0000-0002-2742-8328Kathmann, Norbert\|\|\|0000-0002-1348-7060Kaufmann, ChristianKoch, KathrinKwon, Jun Soo\|\|\|0000-0002-1060-1462Lázaro, Luisa\|\|\|0000-0002-8425-5750Lochner, Christine\|\|\|0000-0002-4766-3704Marsh, Rachel\|\|\|0000-0003-2439-6305Martínez-Zalacaín, Ignacio\|\|\|0000-0002-4036-0284Mataix-Cols, David\|\|\|0000-0002-4545-0924Menchón Magriñá, José Manuel\|\|\|0000-0002-6231-6524Minuzzi, LucianoMorer, AstridNakamae, Takashi\|\|\|0000-0003-4265-198XNakao, TomohiroNarayanaswamy, Janardhanan C.Nishida, SeijiNurmi, Erika L.\|\|\|0000-0003-4893-8957O'Neill, JosephPiacentini, John\|\|\|0000-0003-4195-7194Piras, Fabrizio\|\|\|0000-0003-3566-5494Piras, Federica\|\|\|0000-0002-9546-7038Reddy, Y. C. JanardhanReess, Tim J.Sakai, Yuki\|\|\|0000-0003-2475-8548Sato, Joao R.Simpson, H. BlairSoreni, NoamSoriano-Mas, Carles\|\|\|0000-0003-4574-6597Spalletta, Gianfranco\|\|\|0000-0002-7432-4249Stevens, Michael C.\|\|\|0000-0002-3799-5465Szeszko, Philip R.Tolin, David F.van Wingen, Guido\|\|\|0000-0003-3076-5891Venkatasubramanian, Ganesan\|\|\|0000-0002-0949-898XWalitza, Susanne\|\|\|0000-0002-8161-8683Wang, Zhen\|\|\|0000-0003-4319-5314Yun, Je-Yeon\|\|\|0000-0002-5531-2410Thompson, Paul M.\|\|\|0000-0002-4720-8867Stein, Dan J.\|\|\|0000-0001-7218-7810van den Heuvel, Odile A.\|\|\|0000-0002-9804-7653Twisk, Jos W. R.NeuroimagingMRIIPD meta-analysisMega-analysisLinear mixed-effect modelsObjective: Brain imaging communities focusing on different diseases have increasingly started to collaborate and to pool data to perform well-powered meta- and mega-analyses. Some methodologists claim that a one-stage individual-participant data (IPD) mega-analysis can be superior to a two-stage aggregated data meta-analysis, since more detailed computations can be performed in a mega-analysis. Before definitive conclusions regarding the performance of either method can be drawn, it is necessary to critically evaluate the methodology of, and results obtained by, meta- and mega-analyses. Methods: Here, we compare the inverse variance weighted random-effect meta-analysis model with a multiple linear regression mega-analysis model, as well as with a linear mixed-effects random-intercept mega-analysis model, using data from 38 cohorts including 3,665 participants of the ENIGMA-OCD consortium. We assessed the effect sizes and standard errors, and the fit of the models, to evaluate the performance of the different methods. Results: The mega-analytical models showed lower standard errors and narrower confidence intervals than the meta-analysis. Similar standard errors and confidence intervals were found for the linear regression and linear mixed-effects random-intercept models. Moreover, the linear mixed-effects random-intercept models showed better fit indices compared to linear regression mega-analytical models. Conclusions: Our findings indicate that results obtained by meta- and mega-analysis differ, in favor of the latter. In multi-center studies with a moderate amount of variation between cohorts, a linear mixed-effects random-intercept mega-analytical framework appears to be the better approach to investigate structural neuroimaging data 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/226321https://dx.doi.org/urn:doi:10.3389/fninf.2018.00102reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1247Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2014/SGR-489open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2263212026-06-06T12:50:31Z
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An empirical comparison of meta- and mega-analysis with data from the ENIGMA obsessive-compulsive disorder working group

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