¿Los cambios en la función de las plaquetas contribuyen al desarrollo de la demencia con cuerpos de Lewy?
Lewy body dementia (DLB) is a neurodegenerative disease characterized by a combination of cognitive, motor, and neuropsychiatric symptoms, which complicates its differential diagnosis compared to other pathologies such as Alzheimer's disease (AD) and Parkinson's disease (PD). This study an...
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| Tipo de recurso: | tesis de maestría |
| Fecha de publicación: | 2025 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | español |
| OAI Identifier: | oai:ddd.uab.cat:320184 |
| Acceso en línea: | https://ddd.uab.cat/record/320184 |
| Access Level: | acceso abierto |
| Palabra clave: | Lewy body dementia (DLB) Neurodegenerative disease |
| Sumario: | Lewy body dementia (DLB) is a neurodegenerative disease characterized by a combination of cognitive, motor, and neuropsychiatric symptoms, which complicates its differential diagnosis compared to other pathologies such as Alzheimer's disease (AD) and Parkinson's disease (PD). This study analyzes the expression of genes related to synaptic function and platelet activation in brain tissue (temporal cortex) and in platelets, with the aim of identifying potential peripheral biomarkers for DLB. This work was carried out during my research placement within the GTS (Genomics and Transcriptomics of Synucleinopathies) research group, where I actively participated in experimental procedures and data analysis. The genes SRC, GNB5, CYBB, CD9, DGKE, and P2RY12 were evaluated using qPCR, applying the ΔΔCt method and non-parametric statistical analysis. The results showed significant overexpression of GNB5 in the brains of patients with DLB and PD, and differential expression of SRC, which was increased in the brains of PD/PDD patients and in the platelets of individuals with DLB, PD, and AD. CYBB and P2RY12 were exclusively expressed in the brains of DLB cases, suggesting a distinctive neuroinflammatory profile. In platelets, CD9 was elevated in PD and showed a trend toward increased expression in AD and DLB, whereas GNB5 and CYBB did not show significant changes. These findings suggest an opposing gene regulation pattern between brain and platelets, and support the use of SRC as a potential peripheral biomarker for DLB. Platelets may play an active role in the pathophysiology of this disease, beyond their traditional hemostatic function, opening new diagnostic and therapeutic avenues. |
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