Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©

Introduction This was a multicenter, prospective, longitudinal, observational study involving eight Spanish tertiary hospitals to determine the interobserver reliability of an uveitis disease activity index, (UVEDAI) and assess its sensitivity to change in patients with receiving pharmacologic treat...

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Autores: Pato-Cour E, Borrego-Sanz L, Domínguez-Álvaro M, Sánchez-Alonso F, Rodríguez-González F, Tejera-Santana M, Esteban-Ortega M, García-Lozano I, Martínez-Costa L, González-Ocampo S, Sainz-de-la-Maza M, Moll-Udina A, Plaza Z, Fonollosa A, Artaraz J, Díaz-Valle T, Gurrea-Almela M, Díaz-Valle D, Méndez-Fernández R
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p16978
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/16978
Access Level:acceso abierto
Palabra clave:Uveitis
Composite index
UVEDAI
Interobserver reliability
Sensitivity to change
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spelling Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©Pato-Cour EBorrego-Sanz LDomínguez-Álvaro MSánchez-Alonso FRodríguez-González FTejera-Santana MEsteban-Ortega MGarcía-Lozano IMartínez-Costa LGonzález-Ocampo SSainz-de-la-Maza MMoll-Udina APlaza ZFonollosa AArtaraz JDíaz-Valle TGurrea-Almela MDíaz-Valle DMéndez-Fernández RUveitisComposite indexUVEDAIInterobserver reliabilitySensitivity to changeIntroduction This was a multicenter, prospective, longitudinal, observational study involving eight Spanish tertiary hospitals to determine the interobserver reliability of an uveitis disease activity index, (UVEDAI) and assess its sensitivity to change in patients with receiving pharmacologic treatment. Methods Patients aged >= 18 years diagnosed with active noninfectious uveitis were included. A complete baseline assessment was performed by two ophthalmologists who determined ocular inflammatory activity using the UVEDAI index independently of each other. The principal ophthalmologist made a new visit at 4 weeks to determine the change in inflammatory activity. The interobserver reliability analysis was performed by calculating the intraclass correlation coefficient (ICC), with the values of the variables and the UVEDAI obtained by both ophthalmologists in the more active eye at the baseline visit. Sensitivity to change in the UVEDAI index was assessed at 4 weeks from the start of pharmacologic treatment by determining the clinically relevant change, defined as a change in UVEDAI of >= 0.8 points over baseline. The mean change between both measures was compared using the repeated-measures t-test. Results A total of 111 patients were included. In the interobserver reliability analysis, the ICC for the UVEDAI value was 0.9, and, when compared with the mean UVEDAI values obtained by the ophthalmologists, no statistically significant differences were found (p value > 0.05). As for the sensitivity to change in UVEDAI, statistically significant differences (p value = 0.00) were found for the mean values of the index compared with baseline. In all cases, the index value decreased by > 1 point at the 4-week visit. Conclusions The interobserver reliability of the UVEDAI was high in the total sample. Furthermore, the index was sensitive in determining the change in inflammatory activity after treatment. We believe that UVEDAI is a disease activity index that enables objective comparison of results in clinical practice and trials.SPRINGER INT PUBL AG2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/16978Ophthalmology and TherapyISSN: 21938245ISSNe: 21936528reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p169782026-06-11T12:45:17Z
dc.title.none.fl_str_mv Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
title Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
spellingShingle Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
Pato-Cour E
Uveitis
Composite index
UVEDAI
Interobserver reliability
Sensitivity to change
title_short Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
title_full Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
title_fullStr Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
title_full_unstemmed Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
title_sort Interobserver Reliability and Sensitivity to Change of a Composite Ocular Inflammatory Activity Index: UVEDAI©
dc.creator.none.fl_str_mv Pato-Cour E
Borrego-Sanz L
Domínguez-Álvaro M
Sánchez-Alonso F
Rodríguez-González F
Tejera-Santana M
Esteban-Ortega M
García-Lozano I
Martínez-Costa L
González-Ocampo S
Sainz-de-la-Maza M
Moll-Udina A
Plaza Z
Fonollosa A
Artaraz J
Díaz-Valle T
Gurrea-Almela M
Díaz-Valle D
Méndez-Fernández R
author Pato-Cour E
author_facet Pato-Cour E
Borrego-Sanz L
Domínguez-Álvaro M
Sánchez-Alonso F
Rodríguez-González F
Tejera-Santana M
Esteban-Ortega M
García-Lozano I
Martínez-Costa L
González-Ocampo S
Sainz-de-la-Maza M
Moll-Udina A
Plaza Z
Fonollosa A
Artaraz J
Díaz-Valle T
Gurrea-Almela M
Díaz-Valle D
Méndez-Fernández R
author_role author
author2 Borrego-Sanz L
Domínguez-Álvaro M
Sánchez-Alonso F
Rodríguez-González F
Tejera-Santana M
Esteban-Ortega M
García-Lozano I
Martínez-Costa L
González-Ocampo S
Sainz-de-la-Maza M
Moll-Udina A
Plaza Z
Fonollosa A
Artaraz J
Díaz-Valle T
Gurrea-Almela M
Díaz-Valle D
Méndez-Fernández R
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Uveitis
Composite index
UVEDAI
Interobserver reliability
Sensitivity to change
topic Uveitis
Composite index
UVEDAI
Interobserver reliability
Sensitivity to change
description Introduction This was a multicenter, prospective, longitudinal, observational study involving eight Spanish tertiary hospitals to determine the interobserver reliability of an uveitis disease activity index, (UVEDAI) and assess its sensitivity to change in patients with receiving pharmacologic treatment. Methods Patients aged >= 18 years diagnosed with active noninfectious uveitis were included. A complete baseline assessment was performed by two ophthalmologists who determined ocular inflammatory activity using the UVEDAI index independently of each other. The principal ophthalmologist made a new visit at 4 weeks to determine the change in inflammatory activity. The interobserver reliability analysis was performed by calculating the intraclass correlation coefficient (ICC), with the values of the variables and the UVEDAI obtained by both ophthalmologists in the more active eye at the baseline visit. Sensitivity to change in the UVEDAI index was assessed at 4 weeks from the start of pharmacologic treatment by determining the clinically relevant change, defined as a change in UVEDAI of >= 0.8 points over baseline. The mean change between both measures was compared using the repeated-measures t-test. Results A total of 111 patients were included. In the interobserver reliability analysis, the ICC for the UVEDAI value was 0.9, and, when compared with the mean UVEDAI values obtained by the ophthalmologists, no statistically significant differences were found (p value > 0.05). As for the sensitivity to change in UVEDAI, statistically significant differences (p value = 0.00) were found for the mean values of the index compared with baseline. In all cases, the index value decreased by > 1 point at the 4-week visit. Conclusions The interobserver reliability of the UVEDAI was high in the total sample. Furthermore, the index was sensitive in determining the change in inflammatory activity after treatment. We believe that UVEDAI is a disease activity index that enables objective comparison of results in clinical practice and trials.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/16978
url https://fisabio.portalinvestigacion.com/publicaciones/16978
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER INT PUBL AG
publisher.none.fl_str_mv SPRINGER INT PUBL AG
dc.source.none.fl_str_mv Ophthalmology and Therapy
ISSN: 21938245
ISSNe: 21936528
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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