Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics

Given the potential applications of fluorescent carbon nanoparticles in biomedicine, the relationship between their chemical structure, optical properties and biocompatibility has to be investigated in detail. In this work, different types of fluorescent carbon nanoparticles are synthesized by acid...

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Autores: Vallan, Lorenzo|||0000-0001-5267-4849, Hernández Ferrer, Javier|||0000-0002-6586-6935, Grasa, Laura, González-Domínguez, José Miguel|||0000-0002-0701-7695, Martínez Fernández de Landa, María Teresa, Ballesteros, Belén|||0000-0002-1958-8911, Urriolabeitia, Esteban P., Ansón-Casaos, Alejandro|||0000-0002-3134-8566, Benito, Ana M.|||0000-0002-8654-7386, Maser, Wolfgang K.|||0000-0003-4253-0758
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:222267
Acesso em linha:https://ddd.uab.cat/record/222267
https://dx.doi.org/urn:doi:10.1016/j.colsurfb.2019.110612
Access Level:acceso abierto
Palavra-chave:Carbon dot
Graphene quantum dot
Polymer dot
Fluorescence
Biocompatibility
Toxicity
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spelling Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranosticsVallan, Lorenzo|||0000-0001-5267-4849Hernández Ferrer, Javier|||0000-0002-6586-6935Grasa, LauraGonzález-Domínguez, José Miguel|||0000-0002-0701-7695Martínez Fernández de Landa, María TeresaBallesteros, Belén|||0000-0002-1958-8911Urriolabeitia, Esteban P.Ansón-Casaos, Alejandro|||0000-0002-3134-8566Benito, Ana M.|||0000-0002-8654-7386Maser, Wolfgang K.|||0000-0003-4253-0758Carbon dotGraphene quantum dotPolymer dotFluorescenceBiocompatibilityToxicityGiven the potential applications of fluorescent carbon nanoparticles in biomedicine, the relationship between their chemical structure, optical properties and biocompatibility has to be investigated in detail. In this work, different types of fluorescent carbon nanoparticles are synthesized by acid treatment, sonochemical treatment, electrochemical cleavage and polycondensation. The particle size ranges from 1 to 6 nm, depending on the synthesis method. Nanoparticles that were prepared by acid or sonochemical treatments from graphite keep a crystalline core and can be classified as graphene quantum dots. The electrochemically produced nanoparticles do not clearly show the graphene core, but it is made of heterogeneous aromatic structures with limited size. The polycondensation nanoparticles do not have C[dbnd]C double bonds. The type of functional groups on the carbon backbone and the optical properties, both absorbance and photoluminescence, strongly depend on the nanoparticle origin. The selected types of nanoparticles are compatible with human intestinal cells, while three of them also show activity against colon cancer cells. The widely different properties of the nanoparticle types need to be considered for their use as diagnosis markers and therapeutic vehicles, specifically in the digestive system. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501AMhttp://purl.org/coar/version/c_ab4af688f83e57aainfo:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/222267https://dx.doi.org/urn:doi:10.1016/j.colsurfb.2019.110612reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 ENE2016-79282-C5-1-RMinisterio de Ciencia e Innovación https://doi.org/10.13039/501100004837 UCI-2016-27789Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2017-0706open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2222672026-06-06T12:50:31Z
dc.title.none.fl_str_mv Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
title Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
spellingShingle Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
Vallan, Lorenzo|||0000-0001-5267-4849
Carbon dot
Graphene quantum dot
Polymer dot
Fluorescence
Biocompatibility
Toxicity
title_short Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
title_full Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
title_fullStr Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
title_full_unstemmed Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
title_sort Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics
dc.creator.none.fl_str_mv Vallan, Lorenzo|||0000-0001-5267-4849
Hernández Ferrer, Javier|||0000-0002-6586-6935
Grasa, Laura
González-Domínguez, José Miguel|||0000-0002-0701-7695
Martínez Fernández de Landa, María Teresa
Ballesteros, Belén|||0000-0002-1958-8911
Urriolabeitia, Esteban P.
Ansón-Casaos, Alejandro|||0000-0002-3134-8566
Benito, Ana M.|||0000-0002-8654-7386
Maser, Wolfgang K.|||0000-0003-4253-0758
author Vallan, Lorenzo|||0000-0001-5267-4849
author_facet Vallan, Lorenzo|||0000-0001-5267-4849
Hernández Ferrer, Javier|||0000-0002-6586-6935
Grasa, Laura
González-Domínguez, José Miguel|||0000-0002-0701-7695
Martínez Fernández de Landa, María Teresa
Ballesteros, Belén|||0000-0002-1958-8911
Urriolabeitia, Esteban P.
Ansón-Casaos, Alejandro|||0000-0002-3134-8566
Benito, Ana M.|||0000-0002-8654-7386
Maser, Wolfgang K.|||0000-0003-4253-0758
author_role author
author2 Hernández Ferrer, Javier|||0000-0002-6586-6935
Grasa, Laura
González-Domínguez, José Miguel|||0000-0002-0701-7695
Martínez Fernández de Landa, María Teresa
Ballesteros, Belén|||0000-0002-1958-8911
Urriolabeitia, Esteban P.
Ansón-Casaos, Alejandro|||0000-0002-3134-8566
Benito, Ana M.|||0000-0002-8654-7386
Maser, Wolfgang K.|||0000-0003-4253-0758
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Carbon dot
Graphene quantum dot
Polymer dot
Fluorescence
Biocompatibility
Toxicity
topic Carbon dot
Graphene quantum dot
Polymer dot
Fluorescence
Biocompatibility
Toxicity
description Given the potential applications of fluorescent carbon nanoparticles in biomedicine, the relationship between their chemical structure, optical properties and biocompatibility has to be investigated in detail. In this work, different types of fluorescent carbon nanoparticles are synthesized by acid treatment, sonochemical treatment, electrochemical cleavage and polycondensation. The particle size ranges from 1 to 6 nm, depending on the synthesis method. Nanoparticles that were prepared by acid or sonochemical treatments from graphite keep a crystalline core and can be classified as graphene quantum dots. The electrochemically produced nanoparticles do not clearly show the graphene core, but it is made of heterogeneous aromatic structures with limited size. The polycondensation nanoparticles do not have C[dbnd]C double bonds. The type of functional groups on the carbon backbone and the optical properties, both absorbance and photoluminescence, strongly depend on the nanoparticle origin. The selected types of nanoparticles are compatible with human intestinal cells, while three of them also show activity against colon cancer cells. The widely different properties of the nanoparticle types need to be considered for their use as diagnosis markers and therapeutic vehicles, specifically in the digestive system.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
AM
http://purl.org/coar/version/c_ab4af688f83e57aa
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/222267
https://dx.doi.org/urn:doi:10.1016/j.colsurfb.2019.110612
url https://ddd.uab.cat/record/222267
https://dx.doi.org/urn:doi:10.1016/j.colsurfb.2019.110612
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 ENE2016-79282-C5-1-R
Ministerio de Ciencia e Innovación https://doi.org/10.13039/501100004837 UCI-2016-27789
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 SEV-2017-0706
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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