Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders

Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, the specific and shared underlying...

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Autores: Sadeghi, Iman, Gispert, Juan Domingo, Palumbo, Emilio, Muñoz-Aguirre, Manuel, Wucher, Valentin, D'Argenio, Valeria, Santpere Baró, Gabriel, 1981-, Navarro, Arcadi, Guigó Serra, Roderic, Vilor Tejedor, Natàlia, 1988-
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/54541
Acceso en línea:http://hdl.handle.net/10230/54541
http://dx.doi.org/10.1016/j.csbj.2022.08.037
Access Level:acceso abierto
Palabra clave:Brain cell types
Network analysis
Neurodegeneration
Psychiatric disorder
RNA-Seq
Transcriptome profiling
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spelling Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disordersSadeghi, ImanGispert, Juan DomingoPalumbo, EmilioMuñoz-Aguirre, ManuelWucher, ValentinD'Argenio, ValeriaSantpere Baró, Gabriel, 1981-Navarro, ArcadiGuigó Serra, RodericVilor Tejedor, Natàlia, 1988-Brain cell typesNetwork analysisNeurodegenerationPsychiatric disorderRNA-SeqTranscriptome profilingNeurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, the specific and shared underlying molecular pathobiology of brain illnesses is not clear. Here, we examine transcriptome-wide characterization of eight conditions, using a total of 2,633 post-mortem brain samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), Pathological Aging (PA), Autism Spectrum Disorder (ASD), Schizophrenia (Scz), Major Depressive Disorder (MDD), and Bipolar Disorder (BP)-in comparison with 2,078 brain samples from matched control subjects. Similar transcriptome alterations were observed between NDs and NPs with the top correlations obtained between Scz-BP, ASD-PD, AD-PD, and Scz-ASD. Region-specific comparisons also revealed shared transcriptome alterations in frontal and temporal lobes across NPs and NDs. Co-expression network analysis identified coordinated dysregulations of cell-type-specific modules across NDs and NPs. This study provides a transcriptomic framework to understand the molecular alterations of NPs and NDs through their shared- and specific gene expression in the brain.Elsevier202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54541http://dx.doi.org/10.1016/j.csbj.2022.08.037reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésComput Struct Biotechnol J. 2022 Aug 19;20:4549-61© 2022 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/545412026-06-12T07:21:37Z
dc.title.none.fl_str_mv Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
title Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
spellingShingle Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
Sadeghi, Iman
Brain cell types
Network analysis
Neurodegeneration
Psychiatric disorder
RNA-Seq
Transcriptome profiling
title_short Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
title_full Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
title_fullStr Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
title_full_unstemmed Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
title_sort Brain transcriptomic profiling reveals common alterations across neurodegenerative and psychiatric disorders
dc.creator.none.fl_str_mv Sadeghi, Iman
Gispert, Juan Domingo
Palumbo, Emilio
Muñoz-Aguirre, Manuel
Wucher, Valentin
D'Argenio, Valeria
Santpere Baró, Gabriel, 1981-
Navarro, Arcadi
Guigó Serra, Roderic
Vilor Tejedor, Natàlia, 1988-
author Sadeghi, Iman
author_facet Sadeghi, Iman
Gispert, Juan Domingo
Palumbo, Emilio
Muñoz-Aguirre, Manuel
Wucher, Valentin
D'Argenio, Valeria
Santpere Baró, Gabriel, 1981-
Navarro, Arcadi
Guigó Serra, Roderic
Vilor Tejedor, Natàlia, 1988-
author_role author
author2 Gispert, Juan Domingo
Palumbo, Emilio
Muñoz-Aguirre, Manuel
Wucher, Valentin
D'Argenio, Valeria
Santpere Baró, Gabriel, 1981-
Navarro, Arcadi
Guigó Serra, Roderic
Vilor Tejedor, Natàlia, 1988-
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Brain cell types
Network analysis
Neurodegeneration
Psychiatric disorder
RNA-Seq
Transcriptome profiling
topic Brain cell types
Network analysis
Neurodegeneration
Psychiatric disorder
RNA-Seq
Transcriptome profiling
description Neurodegenerative and neuropsychiatric disorders (ND-NPs) are multifactorial, polygenic and complex behavioral phenotypes caused by brain abnormalities. Large-scale collaborative efforts have tried to identify the genetic architecture of these conditions. However, the specific and shared underlying molecular pathobiology of brain illnesses is not clear. Here, we examine transcriptome-wide characterization of eight conditions, using a total of 2,633 post-mortem brain samples from patients with Alzheimer's disease (AD), Parkinson's disease (PD), Progressive Supranuclear Palsy (PSP), Pathological Aging (PA), Autism Spectrum Disorder (ASD), Schizophrenia (Scz), Major Depressive Disorder (MDD), and Bipolar Disorder (BP)-in comparison with 2,078 brain samples from matched control subjects. Similar transcriptome alterations were observed between NDs and NPs with the top correlations obtained between Scz-BP, ASD-PD, AD-PD, and Scz-ASD. Region-specific comparisons also revealed shared transcriptome alterations in frontal and temporal lobes across NPs and NDs. Co-expression network analysis identified coordinated dysregulations of cell-type-specific modules across NDs and NPs. This study provides a transcriptomic framework to understand the molecular alterations of NPs and NDs through their shared- and specific gene expression in the brain.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/54541
http://dx.doi.org/10.1016/j.csbj.2022.08.037
url http://hdl.handle.net/10230/54541
http://dx.doi.org/10.1016/j.csbj.2022.08.037
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Comput Struct Biotechnol J. 2022 Aug 19;20:4549-61
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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