Leptin as a key regulator of the adipose organ

Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland. Altogether, leptin exert...

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Detalhes bibliográficos
Autores: Picó, Catalina, Palou, Mariona, Amadora Pomar, Catalina, Maria Rodriguez, Ana, Palou, Andreu
Tipo de documento: artigo
Data de publicação:2022
País:España
Recursos:Conselleria de Salut i Consum del Govern de les Illes Balears
Repositório:Docusalut
Idioma:inglês
OAI Identifier:oai:docusalut.com:20.500.13003/19665
Acesso em linha:https://hdl.handle.net/20.500.13003/19665
Access Level:Acceso aberto
Palavra-chave:Diabetes Mellitus, Type 2
Homeostasis
Leptin
Adipose Tissue
Humans
Obesity
Tejido Adiposo
Humanos
Obesidad
Diabetes Mellitus Tipo 2
Leptina
Adipose organ
Adiposity
Energy homeostasis
Metabolic programming
Development
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oai_identifier_str oai:docusalut.com:20.500.13003/19665
network_acronym_str ES
network_name_str España
repository_id_str
spelling Leptin as a key regulator of the adipose organPicó, CatalinaPalou, MarionaAmadora Pomar, CatalinaMaria Rodriguez, AnaPalou, AndreuDiabetes Mellitus, Type 2HomeostasisLeptinAdipose TissueHumansObesityTejido AdiposoHumanosObesidadDiabetes Mellitus Tipo 2HomeostasisLeptinaLeptinAdipose organAdiposityEnergy homeostasisMetabolic programmingDevelopmentLeptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland. Altogether, leptin exerts a broad spectrum of short, medium, and long-term regulatory actions at the central and peripheral levels, including metabolic programming effects that condition the proper development and function of the adipose organ, which are relevant for its main role in energy homeostasis. Comprehending how leptin regulates adipose tissue may provide important clues to understand the pathophysiology of obesity and related diseases, such as type 2 diabetes, as well as its prevention and treatment. This review focuses on the physiological and long-lasting regulatory effects of leptin on adipose tissue, the mechanisms and pathways involved, its main outcomes on whole-body physiological homeostasis, and its consequences on chronic diseases.Springer20222022-02-0120222022-02-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.13003/19665reponame:Docusalutinstname:Conselleria de Salut i Consum del Govern de les Illes BalearsInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docusalut.com:20.500.13003/196652026-06-22T12:44:07Z
dc.title.none.fl_str_mv Leptin as a key regulator of the adipose organ
title Leptin as a key regulator of the adipose organ
spellingShingle Leptin as a key regulator of the adipose organ
Picó, Catalina
Diabetes Mellitus, Type 2
Homeostasis
Leptin
Adipose Tissue
Humans
Obesity
Tejido Adiposo
Humanos
Obesidad
Diabetes Mellitus Tipo 2
Homeostasis
Leptina
Leptin
Adipose organ
Adiposity
Energy homeostasis
Metabolic programming
Development
title_short Leptin as a key regulator of the adipose organ
title_full Leptin as a key regulator of the adipose organ
title_fullStr Leptin as a key regulator of the adipose organ
title_full_unstemmed Leptin as a key regulator of the adipose organ
title_sort Leptin as a key regulator of the adipose organ
dc.creator.none.fl_str_mv Picó, Catalina
Palou, Mariona
Amadora Pomar, Catalina
Maria Rodriguez, Ana
Palou, Andreu
author Picó, Catalina
author_facet Picó, Catalina
Palou, Mariona
Amadora Pomar, Catalina
Maria Rodriguez, Ana
Palou, Andreu
author_role author
author2 Palou, Mariona
Amadora Pomar, Catalina
Maria Rodriguez, Ana
Palou, Andreu
author2_role author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Diabetes Mellitus, Type 2
Homeostasis
Leptin
Adipose Tissue
Humans
Obesity
Tejido Adiposo
Humanos
Obesidad
Diabetes Mellitus Tipo 2
Homeostasis
Leptina
Leptin
Adipose organ
Adiposity
Energy homeostasis
Metabolic programming
Development
topic Diabetes Mellitus, Type 2
Homeostasis
Leptin
Adipose Tissue
Humans
Obesity
Tejido Adiposo
Humanos
Obesidad
Diabetes Mellitus Tipo 2
Homeostasis
Leptina
Leptin
Adipose organ
Adiposity
Energy homeostasis
Metabolic programming
Development
description Leptin is a hormone primarily produced by the adipose tissue in proportion to the size of fat stores, with a primary function in the control of lipid reserves. Besides adipose tissue, leptin is also produced by other tissues, such as the stomach, placenta, and mammary gland. Altogether, leptin exerts a broad spectrum of short, medium, and long-term regulatory actions at the central and peripheral levels, including metabolic programming effects that condition the proper development and function of the adipose organ, which are relevant for its main role in energy homeostasis. Comprehending how leptin regulates adipose tissue may provide important clues to understand the pathophysiology of obesity and related diseases, such as type 2 diabetes, as well as its prevention and treatment. This review focuses on the physiological and long-lasting regulatory effects of leptin on adipose tissue, the mechanisms and pathways involved, its main outcomes on whole-body physiological homeostasis, and its consequences on chronic diseases.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-02-01
2022
2022-02-01
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.13003/19665
url https://hdl.handle.net/20.500.13003/19665
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Docusalut
instname:Conselleria de Salut i Consum del Govern de les Illes Balears
instname_str Conselleria de Salut i Consum del Govern de les Illes Balears
reponame_str Docusalut
collection Docusalut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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