Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain

Background The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. Methods Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detaile...

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Authors: Delgado-Rodriguez, M, Castilla, J, Godoy, P, Martin, V, Soldevila, N, Alonso, J, Astray, J, Baricot, M, Galan, JC, Castro, A, Gonzalez-Candelas, F, Mayoral, JM, Quintana, JM, Pumarola, T, Tamames, S, Saez, M, Dominguez, A, CIBERESP Cases Controls Pandemic
Format: article
Status:Published version
Publication Date:2013
Country:España
Institution:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repository:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p12598
Online Access:https://fisabio.portalinvestigacion.com/publicaciones/12598
Access Level:Open access
Keyword:Hospitalization
influenza
mortality
prognosis
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oai_identifier_str oai:fisabio.fundanetsuite.com:p12598
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spelling Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in SpainDelgado-Rodriguez, MCastilla, JGodoy, PMartin, VSoldevila, NAlonso, JAstray, JBaricot, MGalan, JCCastro, AGonzalez-Candelas, FMayoral, JMQuintana, JMPumarola, TTamames, SSaez, MDominguez, ACIBERESP Cases Controls PandemicHospitalizationinfluenzamortalityprognosisBackground The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. Methods Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. Results Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR = 2.10; 95% confidence intervals CI, 1.55-2.85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR = 3.22, 95% CI, 2.15-4.83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR = 3.77, 95% CI, 2.30-6.18). Conclusion Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.WILEY2013info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/12598Influenza and Other Respiratory VirusesISSN: 17502640ISSNe: 17502659reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p125982026-06-11T12:45:17Z
dc.title.none.fl_str_mv Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
spellingShingle Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
Delgado-Rodriguez, M
Hospitalization
influenza
mortality
prognosis
title_short Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_full Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_fullStr Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_full_unstemmed Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
title_sort Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
dc.creator.none.fl_str_mv Delgado-Rodriguez, M
Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Galan, JC
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author Delgado-Rodriguez, M
author_facet Delgado-Rodriguez, M
Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Galan, JC
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author_role author
author2 Castilla, J
Godoy, P
Martin, V
Soldevila, N
Alonso, J
Astray, J
Baricot, M
Galan, JC
Castro, A
Gonzalez-Candelas, F
Mayoral, JM
Quintana, JM
Pumarola, T
Tamames, S
Saez, M
Dominguez, A
CIBERESP Cases Controls Pandemic
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hospitalization
influenza
mortality
prognosis
topic Hospitalization
influenza
mortality
prognosis
description Background The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. Methods Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. Results Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR = 2.10; 95% confidence intervals CI, 1.55-2.85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR = 3.22, 95% CI, 2.15-4.83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR = 3.77, 95% CI, 2.30-6.18). Conclusion Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.
publishDate 2013
dc.date.none.fl_str_mv 2013
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/12598
url https://fisabio.portalinvestigacion.com/publicaciones/12598
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv Influenza and Other Respiratory Viruses
ISSN: 17502640
ISSNe: 17502659
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419869194158080
score 15.812429

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