Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap

Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic mechanisms, are emerging as promising solutions for activating targeted antimicrobial resp...

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Autores: Nagay, Bruna Egumi, Malheiros, Samuel Santana, Borges, Maria Helena Rossy, Aparicio Bádenas, Conrado José|||0000-0003-2969-6067, van den Beucken, Jeroen J.J.P., Barão, Valentim Adelino Ricardo
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:upcommons.upc.edu:2117/439635
Acceso en línea:https://hdl.handle.net/2117/439635
https://dx.doi.org/10.1016/j.bioactmat.2025.04.037
Access Level:acceso abierto
Palabra clave:Photocatalysis
Implants
Coatings
Light
Biofilms
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Materials dentals
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spelling Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmapNagay, Bruna EgumiMalheiros, Samuel SantanaBorges, Maria Helena RossyAparicio Bádenas, Conrado José|||0000-0003-2969-6067van den Beucken, Jeroen J.J.P.Barão, Valentim Adelino RicardoPhotocatalysisImplantsCoatingsLightBiofilmsÀrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Materials dentalsBiomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic mechanisms, are emerging as promising solutions for activating targeted antimicrobial responses. While extensive reviews have provided insight into photocatalysis and its medical and environmental applications, limited focus has been given to solutions specifically tailored for implant contexts. The recent introduction of photocatalysis in the implant field, particularly visible-light-triggered photocatalytic coatings, represents a versatile approach to managing infections. These coatings offer on-demand reactive oxygen species generation, delivering antibacterial effects against a range of pathogens. Hence, this comprehensive review aims to summarize the latest advancements in design principles, physicochemical modifications, and surface optimizations, along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity. Moreover, through a systematic search, this review discusses the current state-of-the-art regarding the antimicrobial efficacy of these biomaterials and the key factors influencing their performance, including microorganism type, photocatalyst properties, light source and intensity, and exposure time. Finally, it provides an in-depth discussion of current challenges, future directions, and regulatory considerations targeting biofilm-related implant treatments, offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.This work was supported by the State of Sao Paulo Research Foundation (FAPESP) through grants 2019/17238-6, 2020/05231-4, 2022/16267-5, 2024/15196-2, and 2024/02209-9. Additionally, it was supported by the Conselho Nacional de Desenvolvimento Científico Tecnológico (CNPq) (BRICS grant number 440104/2022-0 and 307471/2021-7) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) (Finance Code 001). Schematic figures were created in BioRender. Barao, V. (2025).Peer Reviewed20252025-09-0120252025-07-29journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/439635https://dx.doi.org/10.1016/j.bioactmat.2025.04.037reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:upcommons.upc.edu:2117/4396352026-05-27T15:37:01Z
dc.title.none.fl_str_mv Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
title Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
spellingShingle Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
Nagay, Bruna Egumi
Photocatalysis
Implants
Coatings
Light
Biofilms
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Materials dentals
title_short Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
title_full Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
title_fullStr Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
title_full_unstemmed Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
title_sort Progress in visible-light-activated photocatalytic coatings to combat implant-related infections: From mechanistic to translational roadmap
dc.creator.none.fl_str_mv Nagay, Bruna Egumi
Malheiros, Samuel Santana
Borges, Maria Helena Rossy
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
van den Beucken, Jeroen J.J.P.
Barão, Valentim Adelino Ricardo
author Nagay, Bruna Egumi
author_facet Nagay, Bruna Egumi
Malheiros, Samuel Santana
Borges, Maria Helena Rossy
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
van den Beucken, Jeroen J.J.P.
Barão, Valentim Adelino Ricardo
author_role author
author2 Malheiros, Samuel Santana
Borges, Maria Helena Rossy
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
van den Beucken, Jeroen J.J.P.
Barão, Valentim Adelino Ricardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Photocatalysis
Implants
Coatings
Light
Biofilms
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Materials dentals
topic Photocatalysis
Implants
Coatings
Light
Biofilms
Àrees temàtiques de la UPC::Enginyeria biomèdica::Biomaterials::Materials dentals
description Biomedical and dental implants have enhanced healthcare but concurrently increased the risk of infections. Innovations in smart biomaterials, especially those responding to light stimuli through photocatalytic mechanisms, are emerging as promising solutions for activating targeted antimicrobial responses. While extensive reviews have provided insight into photocatalysis and its medical and environmental applications, limited focus has been given to solutions specifically tailored for implant contexts. The recent introduction of photocatalysis in the implant field, particularly visible-light-triggered photocatalytic coatings, represents a versatile approach to managing infections. These coatings offer on-demand reactive oxygen species generation, delivering antibacterial effects against a range of pathogens. Hence, this comprehensive review aims to summarize the latest advancements in design principles, physicochemical modifications, and surface optimizations, along with novel research concepts towards the achievement of visible-light-triggered photocatalytic antibacterial activity. Moreover, through a systematic search, this review discusses the current state-of-the-art regarding the antimicrobial efficacy of these biomaterials and the key factors influencing their performance, including microorganism type, photocatalyst properties, light source and intensity, and exposure time. Finally, it provides an in-depth discussion of current challenges, future directions, and regulatory considerations targeting biofilm-related implant treatments, offering guidance for future clinical adoption of multifunctional photocatalytic coatings in implant therapy.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-09-01
2025
2025-07-29
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/439635
https://dx.doi.org/10.1016/j.bioactmat.2025.04.037
url https://hdl.handle.net/2117/439635
https://dx.doi.org/10.1016/j.bioactmat.2025.04.037
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
collection UPCommons. Portal del coneixement obert de la UPC
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