Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells

Producción Científica

Detalles Bibliográficos
Autores: Obeso Cáceres, Ana María de la Luz, Gómez Niño, María Ángeles, Almaraz Gómez, Laura, Dinger, Bruce, Fidone, Salvatore, González Martínez, Constancio
Tipo de recurso: artículo
Fecha de publicación:1997
País:España
Institución:Universidad de Valladolid
Repositorio:UVaDOC. Repositorio Documental de la Universidad de Valladolid
OAI Identifier:oai:uvadoc.uva.es:10324/7158
Acceso en línea:https://doi.org/10.1016/s0006-8993(97)00185-6
http://uvadoc.uva.es/handle/10324/7158
Access Level:acceso abierto
Palabra clave:Neurofisiología
Receptores celulares
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spelling Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cellsObeso Cáceres, Ana María de la LuzGómez Niño, María ÁngelesAlmaraz Gómez, LauraDinger, BruceFidone, SalvatoreGonzález Martínez, ConstancioNeurofisiologíaReceptores celularesProducción CientíficaCurrent concepts on the location and functional significance of nicotinic receptors in the carotid body rest on a-bungarotoxin binding and autoradiographic studies. Using an in vitro preparation of the cat carotid body whose catecholamine deposits have been labeled by prior incubation with the tritiated natural precursor w3Hxtyrosine, we have found that nicotine induces release of w3Hxcatecholamines in a dose-dependent manner IC50s9.81 mM.. We also found that mecamylamine 50 mM. completely abolished the nicotine-induced release, while a-bungarotoxin 100 nM; f20 times its binding Kd. only reduced the release by 56%. These findings indicate that chemoreceptor cells, and perhaps other carotid body structures, contain nicotinic receptors that are not sensitive to a-bungarotoxin and force a revision of the current concepts on cholinergic mechanisms in the carotid body chemoreception.Elsevier1997info:eu-repo/semantics/articleapplication/pdfhttps://doi.org/10.1016/s0006-8993(97)00185-6http://uvadoc.uva.es/handle/10324/7158reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolidinstname:Universidad de ValladolidInglésinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:uvadoc.uva.es:10324/71582026-06-13T12:44:47Z
dc.title.none.fl_str_mv Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
title Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
spellingShingle Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
Obeso Cáceres, Ana María de la Luz
Neurofisiología
Receptores celulares
title_short Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
title_full Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
title_fullStr Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
title_full_unstemmed Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
title_sort Evidence for two types of nicotinic receptors in the cat carotid body chemoreceptor cells
dc.creator.none.fl_str_mv Obeso Cáceres, Ana María de la Luz
Gómez Niño, María Ángeles
Almaraz Gómez, Laura
Dinger, Bruce
Fidone, Salvatore
González Martínez, Constancio
author Obeso Cáceres, Ana María de la Luz
author_facet Obeso Cáceres, Ana María de la Luz
Gómez Niño, María Ángeles
Almaraz Gómez, Laura
Dinger, Bruce
Fidone, Salvatore
González Martínez, Constancio
author_role author
author2 Gómez Niño, María Ángeles
Almaraz Gómez, Laura
Dinger, Bruce
Fidone, Salvatore
González Martínez, Constancio
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Neurofisiología
Receptores celulares
topic Neurofisiología
Receptores celulares
description Producción Científica
publishDate 1997
dc.date.none.fl_str_mv 1997
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://doi.org/10.1016/s0006-8993(97)00185-6
http://uvadoc.uva.es/handle/10324/7158
url https://doi.org/10.1016/s0006-8993(97)00185-6
http://uvadoc.uva.es/handle/10324/7158
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:UVaDOC. Repositorio Documental de la Universidad de Valladolid
instname:Universidad de Valladolid
instname_str Universidad de Valladolid
reponame_str UVaDOC. Repositorio Documental de la Universidad de Valladolid
collection UVaDOC. Repositorio Documental de la Universidad de Valladolid
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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