New immunotherapeutic strategies in acute leukemia

Programa de Doctorat en Biomedicina / Tesi realitzada a la Institut de Recerca Josep Carreras

Detalles Bibliográficos
Autor: Tirado Cabrera, Néstor
Tipo de recurso: tesis doctoral
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:CBUC, CESCA
Repositorio:TDR. Tesis Doctorales en Red
OAI Identifier:oai:www.tdx.cat:10803/692700
Acceso en línea:http://hdl.handle.net/10803/692700
Access Level:acceso abierto
Palabra clave:Immunologia
Inmunología
Immunology
Immunoteràpia
Inmunoterapia
Immunotheraphy
Hematologia
Hematología
Hematology
Leucèmia aguda
Leucemia aguda
Acute leukemia
Ciències de la Salut
616.1
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spelling New immunotherapeutic strategies in acute leukemiaTirado Cabrera, NéstorImmunologiaInmunologíaImmunologyImmunoteràpiaInmunoterapiaImmunotheraphyHematologiaHematologíaHematologyLeucèmia agudaLeucemia agudaAcute leukemiaCiències de la Salut616.1Programa de Doctorat en Biomedicina / Tesi realitzada a la Institut de Recerca Josep Carreras[eng] AIMS: The general aim of this doctoral thesis is to improve current CAR-T immunotherapeutic strategies in the treatment of acute leukemias. The specific aims of this doctoral thesis are: 1. To develop and characterize CD123-directed CAR-DOT cells as an allogeneic-safe, off-the-shelf therapy far the treatment of R/R AML. 2. To engineer CD1axCD3 BiTE-secreting STAb-T cells and compare their effectiveness against conventional CD1a-directed CAR-T cells against coT-ALL. 3. To generate a CCR9-directed immunotherapy far the safe treatment of R/R T-ALL. (i) To validate CCR9 as an immunotherapeutic target far T-ALL. (ii) To generate CCR9-directed CAR-T cells. (iii) To generate dual CCR9/CD1 a-directed CARUniversitat de BarcelonaMenéndez Buján, PabloSánchez Martínez, DiegoAgell i Jané, NeusUniversitat de Barcelona. Facultat de Medicina i Ciències de la Salut202420242024info:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/publishedVersion176 p.application/pdfhttp://hdl.handle.net/10803/692700TDX (Tesis Doctorals en Xarxa)reponame:TDR. Tesis Doctorales en Redinstname:CBUC, CESCAInglésL'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-sa/4.0/http://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessoai:www.tdx.cat:10803/6927002026-06-14T12:46:07Z
dc.title.none.fl_str_mv New immunotherapeutic strategies in acute leukemia
title New immunotherapeutic strategies in acute leukemia
spellingShingle New immunotherapeutic strategies in acute leukemia
Tirado Cabrera, Néstor
Immunologia
Inmunología
Immunology
Immunoteràpia
Inmunoterapia
Immunotheraphy
Hematologia
Hematología
Hematology
Leucèmia aguda
Leucemia aguda
Acute leukemia
Ciències de la Salut
616.1
title_short New immunotherapeutic strategies in acute leukemia
title_full New immunotherapeutic strategies in acute leukemia
title_fullStr New immunotherapeutic strategies in acute leukemia
title_full_unstemmed New immunotherapeutic strategies in acute leukemia
title_sort New immunotherapeutic strategies in acute leukemia
dc.creator.none.fl_str_mv Tirado Cabrera, Néstor
author Tirado Cabrera, Néstor
author_facet Tirado Cabrera, Néstor
author_role author
dc.contributor.none.fl_str_mv Menéndez Buján, Pablo
Sánchez Martínez, Diego
Agell i Jané, Neus
Universitat de Barcelona. Facultat de Medicina i Ciències de la Salut
dc.subject.none.fl_str_mv Immunologia
Inmunología
Immunology
Immunoteràpia
Inmunoterapia
Immunotheraphy
Hematologia
Hematología
Hematology
Leucèmia aguda
Leucemia aguda
Acute leukemia
Ciències de la Salut
616.1
topic Immunologia
Inmunología
Immunology
Immunoteràpia
Inmunoterapia
Immunotheraphy
Hematologia
Hematología
Hematology
Leucèmia aguda
Leucemia aguda
Acute leukemia
Ciències de la Salut
616.1
description Programa de Doctorat en Biomedicina / Tesi realitzada a la Institut de Recerca Josep Carreras
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/doctoralThesis
info:eu-repo/semantics/publishedVersion
format doctoralThesis
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10803/692700
url http://hdl.handle.net/10803/692700
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 176 p.
application/pdf
dc.publisher.none.fl_str_mv Universitat de Barcelona
publisher.none.fl_str_mv Universitat de Barcelona
dc.source.none.fl_str_mv TDX (Tesis Doctorals en Xarxa)
reponame:TDR. Tesis Doctorales en Red
instname:CBUC, CESCA
instname_str CBUC, CESCA
reponame_str TDR. Tesis Doctorales en Red
collection TDR. Tesis Doctorales en Red
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419855735685120
score 15,811543

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