Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals

Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and concentrations of cerebrospinal fluid (CSF) AD biomarkers and amyloid-β (Aβ) dep...

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Autores: Alemany, Sílvia, Crous Bou, Marta, Vilor Tejedor, Natalia, Milà Alomà, Marta, Suárez Calvet, Marc, Salvadó, Gemma, Cirach, Marta, Arenaza Urquijo, Eider M., Sánchez Benavides, Gonzalo, Grau Rivera, Oriol, Minguillón, Carolina, Fauria, Karine, Kollmorgen, Gwendlyn, Gispert, Juan Domingo, Gascón, Mireia, Nieuwenhuijsen, Mark J., Zetterberg, Henrik, Blennow, Kaj, Sunyer, Jordi, Molinuevo, José Luis
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/180969
Acceso en línea:https://hdl.handle.net/2445/180969
Access Level:acceso abierto
Palabra clave:Contaminació atmosfèrica
Malaltia d'Alzheimer
Air quality
Alzheimer's disease
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spelling Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individualsAlemany, SílviaCrous Bou, MartaVilor Tejedor, NataliaMilà Alomà, MartaSuárez Calvet, MarcSalvadó, GemmaCirach, MartaArenaza Urquijo, Eider M.Sánchez Benavides, GonzaloGrau Rivera, OriolMinguillón, CarolinaFauria, KarineKollmorgen, GwendlynGispert, Juan DomingoGascón, MireiaNieuwenhuijsen, Mark J.Zetterberg, HenrikBlennow, KajSunyer, JordiMolinuevo, José LuisContaminació atmosfèricaMalaltia d'AlzheimerAir qualityAlzheimer's diseaseBackground: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and concentrations of cerebrospinal fluid (CSF) AD biomarkers and amyloid-β (Aβ) deposition. Participants and methods The sample included 156 cognitively unimpaired adults aged 57 years (61 at biomarkers assessment) with increased risk of AD from the ALFA + Study. We examined CSF levels of Aβ42, Aβ40, p-Tau, t-Tau, neurofilament light (NfL) and cerebral amyloid load (Centiloid). A Land Use Regression model from 2009 was used to estimate residential exposure to air pollutants including nitrogen dioxide (NO2,) and particulate matter (PM2.5, PM2.5 abs, PM10). This model was considered a surrogate of long-term exposure until time of data collection in 2013-2014. Participants have resided in the same residence for at least the previous 3 years. Multiple linear regression models were used to estimate associations between air pollutants and biomarkers. The effect modification by CSF Aβ status and APOE-ε4 carriership was also assessed. Results: A consistent pattern of results indicated that greater exposure to NO2 and PM2.5 absorbance was associated with higher levels of brain Aβ deposition, while greater exposure to PM10 and PM2.5was associated with higher levels of CSF NfL. Most associations were driven by individuals that were Aβ-positive. Although APOE-ε4 status did not significantly modify these associations, the effect of air pollutants exposure on CSF NfL levels was stronger in APOE-ε4 carriers. Conclusion: In a population of cognitively unimpaired adults with increased risk of AD, long-term exposure to air pollution was associated with higher levels in biomarkers of AD pathology. While further research is granted to elucidate the mechanisms involved in such associations, our results reinforce the role of air pollution as an environmental risk factor for AD.Elsevier BV2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/180969Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1016/j.envint.2021.106864Environment International, 2021, vol. 157, p. 106864https://doi.org/10.1016/j.envint.2021.106864info:eu-repo/grantAgreement/EC/H2020/681712info:eu-repo/grantAgreement/EC/H2020/752310cc by-nc-nd (c) Silvia Alemany et al., 2021http://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1809692026-05-27T06:46:51Z
dc.title.none.fl_str_mv Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
title Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
spellingShingle Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
Alemany, Sílvia
Contaminació atmosfèrica
Malaltia d'Alzheimer
Air quality
Alzheimer's disease
title_short Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
title_full Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
title_fullStr Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
title_full_unstemmed Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
title_sort Associations between air pollution and biomarkers of Alzheimer’s disease in cognitively unimpaired individuals
dc.creator.none.fl_str_mv Alemany, Sílvia
Crous Bou, Marta
Vilor Tejedor, Natalia
Milà Alomà, Marta
Suárez Calvet, Marc
Salvadó, Gemma
Cirach, Marta
Arenaza Urquijo, Eider M.
Sánchez Benavides, Gonzalo
Grau Rivera, Oriol
Minguillón, Carolina
Fauria, Karine
Kollmorgen, Gwendlyn
Gispert, Juan Domingo
Gascón, Mireia
Nieuwenhuijsen, Mark J.
Zetterberg, Henrik
Blennow, Kaj
Sunyer, Jordi
Molinuevo, José Luis
author Alemany, Sílvia
author_facet Alemany, Sílvia
Crous Bou, Marta
Vilor Tejedor, Natalia
Milà Alomà, Marta
Suárez Calvet, Marc
Salvadó, Gemma
Cirach, Marta
Arenaza Urquijo, Eider M.
Sánchez Benavides, Gonzalo
Grau Rivera, Oriol
Minguillón, Carolina
Fauria, Karine
Kollmorgen, Gwendlyn
Gispert, Juan Domingo
Gascón, Mireia
Nieuwenhuijsen, Mark J.
Zetterberg, Henrik
Blennow, Kaj
Sunyer, Jordi
Molinuevo, José Luis
author_role author
author2 Crous Bou, Marta
Vilor Tejedor, Natalia
Milà Alomà, Marta
Suárez Calvet, Marc
Salvadó, Gemma
Cirach, Marta
Arenaza Urquijo, Eider M.
Sánchez Benavides, Gonzalo
Grau Rivera, Oriol
Minguillón, Carolina
Fauria, Karine
Kollmorgen, Gwendlyn
Gispert, Juan Domingo
Gascón, Mireia
Nieuwenhuijsen, Mark J.
Zetterberg, Henrik
Blennow, Kaj
Sunyer, Jordi
Molinuevo, José Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Contaminació atmosfèrica
Malaltia d'Alzheimer
Air quality
Alzheimer's disease
topic Contaminació atmosfèrica
Malaltia d'Alzheimer
Air quality
Alzheimer's disease
description Background: Air quality contributes to incidence of Alzheimer's disease (AD) although the underlying neurobiological mechanisms are unclear. This study was aimed to examine the association between air pollution and concentrations of cerebrospinal fluid (CSF) AD biomarkers and amyloid-β (Aβ) deposition. Participants and methods The sample included 156 cognitively unimpaired adults aged 57 years (61 at biomarkers assessment) with increased risk of AD from the ALFA + Study. We examined CSF levels of Aβ42, Aβ40, p-Tau, t-Tau, neurofilament light (NfL) and cerebral amyloid load (Centiloid). A Land Use Regression model from 2009 was used to estimate residential exposure to air pollutants including nitrogen dioxide (NO2,) and particulate matter (PM2.5, PM2.5 abs, PM10). This model was considered a surrogate of long-term exposure until time of data collection in 2013-2014. Participants have resided in the same residence for at least the previous 3 years. Multiple linear regression models were used to estimate associations between air pollutants and biomarkers. The effect modification by CSF Aβ status and APOE-ε4 carriership was also assessed. Results: A consistent pattern of results indicated that greater exposure to NO2 and PM2.5 absorbance was associated with higher levels of brain Aβ deposition, while greater exposure to PM10 and PM2.5was associated with higher levels of CSF NfL. Most associations were driven by individuals that were Aβ-positive. Although APOE-ε4 status did not significantly modify these associations, the effect of air pollutants exposure on CSF NfL levels was stronger in APOE-ε4 carriers. Conclusion: In a population of cognitively unimpaired adults with increased risk of AD, long-term exposure to air pollution was associated with higher levels in biomarkers of AD pathology. While further research is granted to elucidate the mechanisms involved in such associations, our results reinforce the role of air pollution as an environmental risk factor for AD.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/180969
url https://hdl.handle.net/2445/180969
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.envint.2021.106864
Environment International, 2021, vol. 157, p. 106864
https://doi.org/10.1016/j.envint.2021.106864
info:eu-repo/grantAgreement/EC/H2020/681712
info:eu-repo/grantAgreement/EC/H2020/752310
dc.rights.none.fl_str_mv cc by-nc-nd (c) Silvia Alemany et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc-nd (c) Silvia Alemany et al., 2021
http://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier BV
publisher.none.fl_str_mv Elsevier BV
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.300719

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