Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber

Insulin rapidly stimulates glucose transport in muscle fiber. This process controls the utilization of glucose in skeletal muscle, and it is deficient in various insulin-resistant states, such as non-insulin-dependent diabetes mellitus. The effect of insulin on muscle glucose transport is mainly due...

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Detalles Bibliográficos
Autores: Zorzano Olarte, Antonio, Muñoz Moruno, Purificación, Camps Camprubí, Marta, Mora, Conchi, Testar, Xavier, Palacín Prieto, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:1996
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/134865
Acceso en línea:https://hdl.handle.net/2445/134865
Access Level:acceso abierto
Palabra clave:Glucosa
Metabolisme
Glicoproteïnes
Insulina
Fisiologia
Monosacàrids
Músculs
Glucose
Metabolism
Glycoproteins
Insulin
Physiology
Monosaccharides
Muscles
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spelling Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiberZorzano Olarte, AntonioMuñoz Moruno, PurificaciónCamps Camprubí, MartaMora, ConchiTestar, XavierPalacín Prieto, ManuelGlucosaMetabolismeGlicoproteïnesInsulinaFisiologiaMonosacàridsMúsculsGlucoseMetabolismGlycoproteinsInsulinPhysiologyMonosaccharidesMusclesInsulin rapidly stimulates glucose transport in muscle fiber. This process controls the utilization of glucose in skeletal muscle, and it is deficient in various insulin-resistant states, such as non-insulin-dependent diabetes mellitus. The effect of insulin on muscle glucose transport is mainly due to the recruitment of GLUT4 glucose carriers to the cell surface of the muscle fiber. There is increasing evidence that the recruitment of GLUT4 carriers triggered by insulin affects selective domains of sarcolemma and transverse tubules. In contrast, GLUT1 is located mainly in sarcolemma and is absent in transverse tubules, and insulin does not alter its cellular distribution in muscle fiber. The differential distribution of GLUT1 and GLUT4 in the cell surface raises new questions regarding the precise endocytic and exocytic pathways that are functional in the muscle fiber. The current view of insulin-induced GLUT4 translocation is based mainly on studies performed in adipocytes. These studies have proposed the existence of intracellular compartments of GLUT4 that respond to insulin in a highly homogeneous manner. However, studies performed in skeletal muscle have identified insulin-sensitive as well as insulin-insensitive intracellular GLUT4-containing membranes. These data open a new perspective on the dynamics of intracellular GLUT4 compartments in insulin-sensitive cells.American Diabetes Association2019201919962019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1 p.application/pdfhttps://hdl.handle.net/2445/134865Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2337/diab.45.1.S70Diabetes, 1996, vol. 45, num. Suppl 1, p. S70-S81https://doi.org/10.2337/diab.45.1.S70cc-by-nc-nd (c) American Diabetes Association, 1996http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1348652026-05-29T05:05:01Z
dc.title.none.fl_str_mv Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
title Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
spellingShingle Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
Zorzano Olarte, Antonio
Glucosa
Metabolisme
Glicoproteïnes
Insulina
Fisiologia
Monosacàrids
Músculs
Glucose
Metabolism
Glycoproteins
Insulin
Physiology
Monosaccharides
Muscles
title_short Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
title_full Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
title_fullStr Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
title_full_unstemmed Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
title_sort Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber
dc.creator.none.fl_str_mv Zorzano Olarte, Antonio
Muñoz Moruno, Purificación
Camps Camprubí, Marta
Mora, Conchi
Testar, Xavier
Palacín Prieto, Manuel
author Zorzano Olarte, Antonio
author_facet Zorzano Olarte, Antonio
Muñoz Moruno, Purificación
Camps Camprubí, Marta
Mora, Conchi
Testar, Xavier
Palacín Prieto, Manuel
author_role author
author2 Muñoz Moruno, Purificación
Camps Camprubí, Marta
Mora, Conchi
Testar, Xavier
Palacín Prieto, Manuel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Glucosa
Metabolisme
Glicoproteïnes
Insulina
Fisiologia
Monosacàrids
Músculs
Glucose
Metabolism
Glycoproteins
Insulin
Physiology
Monosaccharides
Muscles
topic Glucosa
Metabolisme
Glicoproteïnes
Insulina
Fisiologia
Monosacàrids
Músculs
Glucose
Metabolism
Glycoproteins
Insulin
Physiology
Monosaccharides
Muscles
description Insulin rapidly stimulates glucose transport in muscle fiber. This process controls the utilization of glucose in skeletal muscle, and it is deficient in various insulin-resistant states, such as non-insulin-dependent diabetes mellitus. The effect of insulin on muscle glucose transport is mainly due to the recruitment of GLUT4 glucose carriers to the cell surface of the muscle fiber. There is increasing evidence that the recruitment of GLUT4 carriers triggered by insulin affects selective domains of sarcolemma and transverse tubules. In contrast, GLUT1 is located mainly in sarcolemma and is absent in transverse tubules, and insulin does not alter its cellular distribution in muscle fiber. The differential distribution of GLUT1 and GLUT4 in the cell surface raises new questions regarding the precise endocytic and exocytic pathways that are functional in the muscle fiber. The current view of insulin-induced GLUT4 translocation is based mainly on studies performed in adipocytes. These studies have proposed the existence of intracellular compartments of GLUT4 that respond to insulin in a highly homogeneous manner. However, studies performed in skeletal muscle have identified insulin-sensitive as well as insulin-insensitive intracellular GLUT4-containing membranes. These data open a new perspective on the dynamics of intracellular GLUT4 compartments in insulin-sensitive cells.
publishDate 1996
dc.date.none.fl_str_mv 1996
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134865
url https://hdl.handle.net/2445/134865
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2337/diab.45.1.S70
Diabetes, 1996, vol. 45, num. Suppl 1, p. S70-S81
https://doi.org/10.2337/diab.45.1.S70
dc.rights.none.fl_str_mv cc-by-nc-nd (c) American Diabetes Association, 1996
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) American Diabetes Association, 1996
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1 p.
application/pdf
dc.publisher.none.fl_str_mv American Diabetes Association
publisher.none.fl_str_mv American Diabetes Association
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869419797779841024
score 15,811543

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