Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study

Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary...

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Autores: Iglesias Vázquez, Lucía, Arija, Victoria, Aranda, Núria, Aglago, Elom K, Cross, Amanda J., Schulze, Matthias B., Quintana Pacheco, Daniel, Kühn, Tilman, Weiderpass, Elisabete, Tumino, Rosario, Redondo‑Sánchez, Daniel, Santucci de Magistris, Maria, Palli, Domenico, Ardanaz, Eva, Laouali, Nasser, Sonestedt, Emily, Drake, Isabel, Rizzolo-Brime, Lucía, Santiuste, Carmen, Sacerdote, Carlotta, Quirós, José Ramón, Amiano, Pilar, Agudo, Antonio, Jakszyn, Paula
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:20.500.14342/3897
Acceso en línea:http://hdl.handle.net/20.500.14342/3897
https://doi.org/10.1007/s00394-021-02625-w
Access Level:acceso abierto
Palabra clave:Ferritina
Ferro en l'organisme
Excès de ferro
EPIC
613
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spelling Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast studyIglesias Vázquez, LucíaArija, VictoriaAranda, NúriaAglago, Elom KCross, Amanda J.Schulze, Matthias B.Quintana Pacheco, DanielKühn, TilmanWeiderpass, ElisabeteTumino, RosarioRedondo‑Sánchez, DanielSantucci de Magistris, MariaPalli, DomenicoArdanaz, EvaLaouali, NasserSonestedt, EmilyDrake, IsabelRizzolo-Brime, LucíaSantiuste, CarmenSacerdote, CarlottaQuirós, José RamónAmiano, PilarAgudo, AntonioJakszyn, PaulaFerritinaFerro en l'organismeExcès de ferroEPIC613Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case–control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic infammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was signifcantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex diferences even after excluding participants with hsCRP>5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.info:eu-repo/semantics/acceptedVersionSpringer NatureUniversitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna2021info:eu-repo/semantics/article14 p.http://hdl.handle.net/20.500.14342/3897https://doi.org/10.1007/s00394-021-02625-wreponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésEuropean Journal of Nutrition, 2022, 61: 101-114info:eu-repo/grantAgreement/MINECO/ISCIII/PI11© Springer Nature. Tots els drets reservatsinfo:eu-repo/semantics/openAccessoai:recercat.cat:20.500.14342/38972026-05-29T05:05:01Z
dc.title.none.fl_str_mv Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
title Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
spellingShingle Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
Iglesias Vázquez, Lucía
Ferritina
Ferro en l'organisme
Excès de ferro
EPIC
613
title_short Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
title_full Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
title_fullStr Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
title_full_unstemmed Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
title_sort Factors associated with serum ferritin levels and iron excess: results from the EPIC‑EurGast study
dc.creator.none.fl_str_mv Iglesias Vázquez, Lucía
Arija, Victoria
Aranda, Núria
Aglago, Elom K
Cross, Amanda J.
Schulze, Matthias B.
Quintana Pacheco, Daniel
Kühn, Tilman
Weiderpass, Elisabete
Tumino, Rosario
Redondo‑Sánchez, Daniel
Santucci de Magistris, Maria
Palli, Domenico
Ardanaz, Eva
Laouali, Nasser
Sonestedt, Emily
Drake, Isabel
Rizzolo-Brime, Lucía
Santiuste, Carmen
Sacerdote, Carlotta
Quirós, José Ramón
Amiano, Pilar
Agudo, Antonio
Jakszyn, Paula
author Iglesias Vázquez, Lucía
author_facet Iglesias Vázquez, Lucía
Arija, Victoria
Aranda, Núria
Aglago, Elom K
Cross, Amanda J.
Schulze, Matthias B.
Quintana Pacheco, Daniel
Kühn, Tilman
Weiderpass, Elisabete
Tumino, Rosario
Redondo‑Sánchez, Daniel
Santucci de Magistris, Maria
Palli, Domenico
Ardanaz, Eva
Laouali, Nasser
Sonestedt, Emily
Drake, Isabel
Rizzolo-Brime, Lucía
Santiuste, Carmen
Sacerdote, Carlotta
Quirós, José Ramón
Amiano, Pilar
Agudo, Antonio
Jakszyn, Paula
author_role author
author2 Arija, Victoria
Aranda, Núria
Aglago, Elom K
Cross, Amanda J.
Schulze, Matthias B.
Quintana Pacheco, Daniel
Kühn, Tilman
Weiderpass, Elisabete
Tumino, Rosario
Redondo‑Sánchez, Daniel
Santucci de Magistris, Maria
Palli, Domenico
Ardanaz, Eva
Laouali, Nasser
Sonestedt, Emily
Drake, Isabel
Rizzolo-Brime, Lucía
Santiuste, Carmen
Sacerdote, Carlotta
Quirós, José Ramón
Amiano, Pilar
Agudo, Antonio
Jakszyn, Paula
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Ramon Llull. Facultat de Ciències de la Salut Blanquerna
dc.subject.none.fl_str_mv Ferritina
Ferro en l'organisme
Excès de ferro
EPIC
613
topic Ferritina
Ferro en l'organisme
Excès de ferro
EPIC
613
description Purpose Excess iron is involved in the development of non-communicable diseases such as cancer, type 2 diabetes and cardiovascular conditions. We aimed to describe the prevalence of excess iron and its determinants in healthy European adults. Methods Sociodemographic, lifestyle, iron status, dietary information, and HFE genotyping were obtained from controls from the nested case–control study EPIC-EurGast study. High sensitivity C-reactive protein (hsCRP) was measured to address possible systemic infammation. Descriptive and multivariate analyses were used to assess iron status and its determinants. Results Out of the 828 participants (median age: 58.7 years), 43% were females. Median serum ferritin and prevalence of excess iron were 143.7 µg/L and 35.2% in males, respectively, and 77 µg/L and 20% in females, both increasing with latitude across Europe. Prevalence of HFE C282Y mutation was signifcantly higher in Northern and Central Europe (~ 11%) than in the South (5%). Overweight/obesity, age, and daily alcohol and heme iron intake were independent determinants for iron status, with sex diferences even after excluding participants with hsCRP>5 mg/L. Obese males showed a greater consumption of alcohol, total and red meat, and heme iron, compared with those normal weight. Conclusion Obesity, higher alcohol and heme iron consumption were the main risk factors for excess iron in males while only age was associated with iron overload in females. Weight control and promoting healthy lifestyle may help prevent iron overload, especially in obese people. Further research is needed to clarify determinants of excess iron in the healthy adult population, helping to reduce the associated comorbidities.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.14342/3897
https://doi.org/10.1007/s00394-021-02625-w
url http://hdl.handle.net/20.500.14342/3897
https://doi.org/10.1007/s00394-021-02625-w
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv European Journal of Nutrition, 2022, 61: 101-114
info:eu-repo/grantAgreement/MINECO/ISCIII/PI11
dc.rights.none.fl_str_mv © Springer Nature. Tots els drets reservats
info:eu-repo/semantics/openAccess
rights_invalid_str_mv © Springer Nature. Tots els drets reservats
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 14 p.
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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