Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR
The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:286570 |
| Acesso em linha: | https://ddd.uab.cat/record/286570 https://dx.doi.org/urn:doi:10.1038/s41598-019-48592-5 |
| Access Level: | acceso abierto |
| Palavra-chave: | Antibodies Hepatitis C Hepatitis C virus |
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oai:ddd.uab.cat:286570 |
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| network_name_str |
España |
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| dc.title.none.fl_str_mv |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| title |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| spellingShingle |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR Vigón, Lorena Antibodies Hepatitis C Hepatitis C virus |
| title_short |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| title_full |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| title_fullStr |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| title_full_unstemmed |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| title_sort |
Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVR |
| dc.creator.none.fl_str_mv |
Vigón, Lorena Vázquez-Morón, Sonia|||0000-0002-0977-741X Berenguer, Juan|||0000-0001-8541-8200 González-García, Juan|||0000-0002-3652-002X Jiménez-Sousa, Ma Ángeles Guardiola Tey, Jose Maria|||0000-0001-5537-2600 Crespo Casal, Manuel|||0000-0001-9016-0515 de los Santos Gil, Ignacio|||0000-0001-7073-5211 Von Wichmann, Miguel Ángel Carrero, Ana Yélamos, María Belén Gómez, Julián Resino, Salvador|||0000-0001-8783-0450 Martínez, Isidoro|||0000-0002-9949-9264 Miralles, Pilar López, J.C. Parras, F. Padilla Ortega, Belén Aldámiz-Echevarría, T. Tejerina, F. Diez, Cristina Pérez-Latorre, L. Fanciulli, Chiara|||0000-0003-2175-9027 Gutiérrez, I. Ramírez, Manuel|||0000-0003-0332-6973 Carretero, S. Bellón, José-María|||0000-0002-8492-1565 Bermejo, Javier|||0000-0002-5241-2758 Hontañón, V. Arribas, Jose|||0000-0002-7410-9450 Montes, M.L. Bernardino, I. Pascual, J.F. Zamora, Francisco Peña, J.M. Arnalich, F. Díaz, M. Domingo Pedrol, Pedro|||0000-0003-1138-5770 Sanz, Jaime|||0000-0001-6934-4619 Bustinduy, M.J. Iribarren, José Antonio Rodríguez-Arrondo, F. Eynde, E.Van den Pérez, M. Ribera, E. Casado, José Luis|||0000-0002-7639-8591 Dronda, Fernando|||0000-0002-0443-5816 Moreno, A. Pérez Elías, Mª Jesus|||0000-0001-5700-5257 Sanfrutos, M.A. Moreno, S. Quereda, Carmen Arranz, A. Casas Díaz, Encarna|||0000-0002-5901-6555 Miguel, J.de Schroeder, S. Vergas, J. Téllez, M.J. Vinuesa, D. Muñoz, Lourdes Hernández Quero, José Ferrer, A. Galindo, María José Ortiz, L. Ortega, Emilio|||0000-0002-2217-8905 Montero, M. Blanes, M. Cuellar, S. Lacruz, José Salavert, Miguel|||0000-0002-8571-2124 López-Aldeguer, J. Pérez González, Gustavo|||0000-0001-9112-9042 Gaspar, G. Yllescas, M. Crespo, P. Aznar, E. Esteban, H. |
| author |
Vigón, Lorena |
| author_facet |
Vigón, Lorena Vázquez-Morón, Sonia|||0000-0002-0977-741X Berenguer, Juan|||0000-0001-8541-8200 González-García, Juan|||0000-0002-3652-002X Jiménez-Sousa, Ma Ángeles Guardiola Tey, Jose Maria|||0000-0001-5537-2600 Crespo Casal, Manuel|||0000-0001-9016-0515 de los Santos Gil, Ignacio|||0000-0001-7073-5211 Von Wichmann, Miguel Ángel Carrero, Ana Yélamos, María Belén Gómez, Julián Resino, Salvador|||0000-0001-8783-0450 Martínez, Isidoro|||0000-0002-9949-9264 Miralles, Pilar López, J.C. Parras, F. Padilla Ortega, Belén Aldámiz-Echevarría, T. Tejerina, F. Diez, Cristina Pérez-Latorre, L. Fanciulli, Chiara|||0000-0003-2175-9027 Gutiérrez, I. Ramírez, Manuel|||0000-0003-0332-6973 Carretero, S. Bellón, José-María|||0000-0002-8492-1565 Bermejo, Javier|||0000-0002-5241-2758 Hontañón, V. Arribas, Jose|||0000-0002-7410-9450 Montes, M.L. Bernardino, I. Pascual, J.F. Zamora, Francisco Peña, J.M. Arnalich, F. Díaz, M. Domingo Pedrol, Pedro|||0000-0003-1138-5770 Sanz, Jaime|||0000-0001-6934-4619 Bustinduy, M.J. Iribarren, José Antonio Rodríguez-Arrondo, F. Eynde, E.Van den Pérez, M. Ribera, E. Casado, José Luis|||0000-0002-7639-8591 Dronda, Fernando|||0000-0002-0443-5816 Moreno, A. Pérez Elías, Mª Jesus|||0000-0001-5700-5257 Sanfrutos, M.A. Moreno, S. Quereda, Carmen Arranz, A. Casas Díaz, Encarna|||0000-0002-5901-6555 Miguel, J.de Schroeder, S. Vergas, J. Téllez, M.J. Vinuesa, D. Muñoz, Lourdes Hernández Quero, José Ferrer, A. Galindo, María José Ortiz, L. Ortega, Emilio|||0000-0002-2217-8905 Montero, M. Blanes, M. Cuellar, S. Lacruz, José Salavert, Miguel|||0000-0002-8571-2124 López-Aldeguer, J. Pérez González, Gustavo|||0000-0001-9112-9042 Gaspar, G. Yllescas, M. Crespo, P. Aznar, E. Esteban, H. |
| author_role |
author |
| author2 |
Vázquez-Morón, Sonia|||0000-0002-0977-741X Berenguer, Juan|||0000-0001-8541-8200 González-García, Juan|||0000-0002-3652-002X Jiménez-Sousa, Ma Ángeles Guardiola Tey, Jose Maria|||0000-0001-5537-2600 Crespo Casal, Manuel|||0000-0001-9016-0515 de los Santos Gil, Ignacio|||0000-0001-7073-5211 Von Wichmann, Miguel Ángel Carrero, Ana Yélamos, María Belén Gómez, Julián Resino, Salvador|||0000-0001-8783-0450 Martínez, Isidoro|||0000-0002-9949-9264 Miralles, Pilar López, J.C. Parras, F. Padilla Ortega, Belén Aldámiz-Echevarría, T. Tejerina, F. Diez, Cristina Pérez-Latorre, L. Fanciulli, Chiara|||0000-0003-2175-9027 Gutiérrez, I. Ramírez, Manuel|||0000-0003-0332-6973 Carretero, S. Bellón, José-María|||0000-0002-8492-1565 Bermejo, Javier|||0000-0002-5241-2758 Hontañón, V. Arribas, Jose|||0000-0002-7410-9450 Montes, M.L. Bernardino, I. Pascual, J.F. Zamora, Francisco Peña, J.M. Arnalich, F. Díaz, M. Domingo Pedrol, Pedro|||0000-0003-1138-5770 Sanz, Jaime|||0000-0001-6934-4619 Bustinduy, M.J. Iribarren, José Antonio Rodríguez-Arrondo, F. Eynde, E.Van den Pérez, M. Ribera, E. Casado, José Luis|||0000-0002-7639-8591 Dronda, Fernando|||0000-0002-0443-5816 Moreno, A. Pérez Elías, Mª Jesus|||0000-0001-5700-5257 Sanfrutos, M.A. Moreno, S. Quereda, Carmen Arranz, A. Casas Díaz, Encarna|||0000-0002-5901-6555 Miguel, J.de Schroeder, S. Vergas, J. Téllez, M.J. Vinuesa, D. Muñoz, Lourdes Hernández Quero, José Ferrer, A. Galindo, María José Ortiz, L. Ortega, Emilio|||0000-0002-2217-8905 Montero, M. Blanes, M. Cuellar, S. Lacruz, José Salavert, Miguel|||0000-0002-8571-2124 López-Aldeguer, J. Pérez González, Gustavo|||0000-0001-9112-9042 Gaspar, G. Yllescas, M. Crespo, P. Aznar, E. Esteban, H. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Antibodies Hepatitis C Hepatitis C virus |
| topic |
Antibodies Hepatitis C Hepatitis C virus |
| description |
The main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with peg-IFNα + ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against five JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVR. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2 2019-01-01 2019 2019-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/286570 https://dx.doi.org/urn:doi:10.1038/s41598-019-48592-5 |
| url |
https://ddd.uab.cat/record/286570 https://dx.doi.org/urn:doi:10.1038/s41598-019-48592-5 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD12/0017/0037 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01094 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00657 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00903 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0018 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0017 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 INT15/00079 Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 INT16/00100 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Rapid decrease in titer and breadth of neutralizing anti-HCV antibodies in HIV/HCV-coinfected patients who achieved SVRVigón, LorenaVázquez-Morón, Sonia|||0000-0002-0977-741XBerenguer, Juan|||0000-0001-8541-8200González-García, Juan|||0000-0002-3652-002XJiménez-Sousa, Ma ÁngelesGuardiola Tey, Jose Maria|||0000-0001-5537-2600Crespo Casal, Manuel|||0000-0001-9016-0515de los Santos Gil, Ignacio|||0000-0001-7073-5211Von Wichmann, Miguel ÁngelCarrero, AnaYélamos, María BelénGómez, JuliánResino, Salvador|||0000-0001-8783-0450Martínez, Isidoro|||0000-0002-9949-9264Miralles, PilarLópez, J.C.Parras, F.Padilla Ortega, BelénAldámiz-Echevarría, T.Tejerina, F.Diez, CristinaPérez-Latorre, L.Fanciulli, Chiara|||0000-0003-2175-9027Gutiérrez, I.Ramírez, Manuel|||0000-0003-0332-6973Carretero, S.Bellón, José-María|||0000-0002-8492-1565Bermejo, Javier|||0000-0002-5241-2758Hontañón, V.Arribas, Jose|||0000-0002-7410-9450Montes, M.L.Bernardino, I.Pascual, J.F.Zamora, FranciscoPeña, J.M.Arnalich, F.Díaz, M.Domingo Pedrol, Pedro|||0000-0003-1138-5770Sanz, Jaime|||0000-0001-6934-4619Bustinduy, M.J.Iribarren, José AntonioRodríguez-Arrondo, F.Eynde, E.Van denPérez, M.Ribera, E.Casado, José Luis|||0000-0002-7639-8591Dronda, Fernando|||0000-0002-0443-5816Moreno, A.Pérez Elías, Mª Jesus|||0000-0001-5700-5257Sanfrutos, M.A.Moreno, S.Quereda, CarmenArranz, A.Casas Díaz, Encarna|||0000-0002-5901-6555Miguel, J.deSchroeder, S.Vergas, J.Téllez, M.J.Vinuesa, D.Muñoz, LourdesHernández Quero, JoséFerrer, A.Galindo, María JoséOrtiz, L.Ortega, Emilio|||0000-0002-2217-8905Montero, M.Blanes, M.Cuellar, S.Lacruz, JoséSalavert, Miguel|||0000-0002-8571-2124López-Aldeguer, J.Pérez González, Gustavo|||0000-0001-9112-9042Gaspar, G.Yllescas, M.Crespo, P.Aznar, E.Esteban, H.AntibodiesHepatitis CHepatitis C virusThe main targets for neutralizing anti-hepatitis C virus (HCV) antibodies (HCV-nAbs) are the E1 and E2 envelope glycoproteins. We have studied the characteristics of HCV-nAbs through a retrospective study involving 29 HIV/HCV-coinfected patients who achieved sustained virological response (SVR) with peg-IFNα + ribavirin anti-HCV therapy. Plasma samples at baseline and week 24 after SVR were used to perform neutralization assays against five JFH1-based HCV recombinant viruses coding for E1 and E2 from genotypes 1a (H77), 1b (J4), 2a (JFH1), 3a (S52) and 4a (ED43). At baseline, the majority of plasma samples neutralized 1a, 1b, 2a, and 4a, but not 3a, genotypes. Twenty-four weeks following SVR, most neutralizing titers declined substantially. Furthermore, titers against 3a and 2a were not detected in many patients. Plasma samples with high HCV-nAb titers neutralized all genotypes, and the highest titers at the starting point correlated with the highest titers at week 24 after SVR. In conclusion, high titers of broad-spectrum HCV-nAbs were detected in HIV/HCV-coinfected individuals, however, those titers declined soon after SVR.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/286570https://dx.doi.org/urn:doi:10.1038/s41598-019-48592-5reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD12/0017/0037Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI14/01094Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00657Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/00903Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0018Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD16/0025/0017Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 INT15/00079Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 INT16/00100open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2865702026-06-06T12:50:31Z |
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15,300724 |