Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control

© The Author 2025. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Detalles Bibliográficos
Autor: Becana Ausejo, Manuel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/392597
Acceso en línea:http://hdl.handle.net/10261/392597
Access Level:acceso abierto
Palabra clave:Common bean
cytokinins
legume nodules
nitrogen fixation
purine salvage pathway
ureides
legumes
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spelling Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation controlBecana Ausejo, ManuelCommon beancytokininslegume nodulesnitrogen fixationpurine salvage pathwayureideslegumesnitrogen fixation© The Author 2025. Published by Oxford University Press on behalf of the Society for Experimental Biology.Purine nucleotides are key metabolites of plants because they are constituents of nucleic acids and participate in energy and nitrogen metabolism. They are produced by de novo synthesis or salvage pathways, the latter being energetically favorable. By using CRISPR/Cas9 gene down-regulation along with omics technologies in common bean, López et al. (2025) unveiled functional specialization of two isoforms of adenine phosphoribosyltransferase (APRT) impacting the fate of adenine. Notably, APRT1 played a prevalent role in adenine salvage in roots, whereas APRT5 is involved in cytokinin homeostasis and stress responses. Furthermore, experiments with transgenic hairy roots showed that nodules with down-regulated APRT5 have a considerably larger size and weight than wild-type nodules, indicating a previously unknown function of some APRTs in regulating nodulation.Research in the author’s laboratory is funded by MCIN/AEI/10.13039/ 501100011033 (grant PID2020-113985GB-I00).Peer reviewedOxford University PressMinisterio de Ciencia e Innovación (España)Becana Ausejo, Manuel [0000-0002-1083-0804]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202520252025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/392597reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113985GB-I00https://doi.org/10.1093/jxb/eraf008Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3925972026-05-22T06:33:51Z
dc.title.none.fl_str_mv Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
title Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
spellingShingle Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
Becana Ausejo, Manuel
Common bean
cytokinins
legume nodules
nitrogen fixation
purine salvage pathway
ureides
legumes
nitrogen fixation
title_short Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
title_full Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
title_fullStr Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
title_full_unstemmed Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
title_sort Recycling of purine nucleotides in legumes: functional specialization of enzyme isoforms in adenine salvage, cytokinin homeostasis, and nodulation control
dc.creator.none.fl_str_mv Becana Ausejo, Manuel
author Becana Ausejo, Manuel
author_facet Becana Ausejo, Manuel
author_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Becana Ausejo, Manuel [0000-0002-1083-0804]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Common bean
cytokinins
legume nodules
nitrogen fixation
purine salvage pathway
ureides
legumes
nitrogen fixation
topic Common bean
cytokinins
legume nodules
nitrogen fixation
purine salvage pathway
ureides
legumes
nitrogen fixation
description © The Author 2025. Published by Oxford University Press on behalf of the Society for Experimental Biology.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/392597
url http://hdl.handle.net/10261/392597
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113985GB-I00
https://doi.org/10.1093/jxb/eraf008
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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