Differences in breast cancer risk after benign breast disease by type of screening diagnosis

Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer sc...

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Autores: Louro, Javier, Román, Marta, Posso, Margarita, Comerma Blesa, Laura, 1983-, Vidal, Carmen, Saladié, Francina, Alcantara Souza, Rodrigo, Sánchez, Mar, Quintana, María Jesús, Del Riego, Javier, Ferrer, Joana, Peñalva, Lupe, Bargalló Castelló, Xavier, Prieto, Miguel, Sala i Serra, Maria, Castells, Xavier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universitat Pompeu Fabra
Repositorio:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/47746
Acceso en línea:http://hdl.handle.net/10230/47746
http://dx.doi.org/10.1016/j.breast.2020.09.005
Access Level:acceso abierto
Palabra clave:Benign breast disease
Breast neoplasms
Early cancer detection
Risk factors
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spelling Differences in breast cancer risk after benign breast disease by type of screening diagnosisLouro, JavierRomán, MartaPosso, MargaritaComerma Blesa, Laura, 1983-Vidal, CarmenSaladié, FrancinaAlcantara Souza, RodrigoSánchez, MarQuintana, María JesúsDel Riego, JavierFerrer, JoanaPeñalva, LupeBargalló Castelló, XavierPrieto, MiguelSala i Serra, MariaCastells, XavierBenign breast diseaseBreast neoplasmsEarly cancer detectionRisk factorsIntroduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis.Elsevier202120212020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/47746http://dx.doi.org/10.1016/j.breast.2020.09.005reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésCopyright © 2020 The Authors. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).http://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/477462026-06-12T07:21:37Z
dc.title.none.fl_str_mv Differences in breast cancer risk after benign breast disease by type of screening diagnosis
title Differences in breast cancer risk after benign breast disease by type of screening diagnosis
spellingShingle Differences in breast cancer risk after benign breast disease by type of screening diagnosis
Louro, Javier
Benign breast disease
Breast neoplasms
Early cancer detection
Risk factors
title_short Differences in breast cancer risk after benign breast disease by type of screening diagnosis
title_full Differences in breast cancer risk after benign breast disease by type of screening diagnosis
title_fullStr Differences in breast cancer risk after benign breast disease by type of screening diagnosis
title_full_unstemmed Differences in breast cancer risk after benign breast disease by type of screening diagnosis
title_sort Differences in breast cancer risk after benign breast disease by type of screening diagnosis
dc.creator.none.fl_str_mv Louro, Javier
Román, Marta
Posso, Margarita
Comerma Blesa, Laura, 1983-
Vidal, Carmen
Saladié, Francina
Alcantara Souza, Rodrigo
Sánchez, Mar
Quintana, María Jesús
Del Riego, Javier
Ferrer, Joana
Peñalva, Lupe
Bargalló Castelló, Xavier
Prieto, Miguel
Sala i Serra, Maria
Castells, Xavier
author Louro, Javier
author_facet Louro, Javier
Román, Marta
Posso, Margarita
Comerma Blesa, Laura, 1983-
Vidal, Carmen
Saladié, Francina
Alcantara Souza, Rodrigo
Sánchez, Mar
Quintana, María Jesús
Del Riego, Javier
Ferrer, Joana
Peñalva, Lupe
Bargalló Castelló, Xavier
Prieto, Miguel
Sala i Serra, Maria
Castells, Xavier
author_role author
author2 Román, Marta
Posso, Margarita
Comerma Blesa, Laura, 1983-
Vidal, Carmen
Saladié, Francina
Alcantara Souza, Rodrigo
Sánchez, Mar
Quintana, María Jesús
Del Riego, Javier
Ferrer, Joana
Peñalva, Lupe
Bargalló Castelló, Xavier
Prieto, Miguel
Sala i Serra, Maria
Castells, Xavier
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Benign breast disease
Breast neoplasms
Early cancer detection
Risk factors
topic Benign breast disease
Breast neoplasms
Early cancer detection
Risk factors
description Introduction: We aimed to assess differences in breast cancer risk across benign breast disease diagnosed at prevalent or incident screens. Materials and methods: We conducted a retrospective cohort study with data from 629,087 women participating in a long-standing population-based breast cancer screening program in Spain. Each benign breast disease was classified as non-proliferative, proliferative without atypia, or proliferative with atypia, and whether it was diagnosed in a prevalent or incident screen. We used partly conditional Cox hazard regression to estimate the adjusted hazard ratios of the risk of breast cancer. Results: Compared with women without benign breast disease, the risk of breast cancer was significantly higher (p-value = 0.005) in women with benign breast disease diagnosed in an incident screen (aHR, 2.67; 95%CI: 2.24-3.19) than in those with benign breast disease diagnosed in a prevalent screen (aHR, 1.87; 95%CI: 1.57-2.24). The highest risk was found in women with a proliferative benign breast disease with atypia (aHR, 4.35; 95%CI: 2.09-9.08, and 3.35; 95%CI: 1.51-7.40 for those diagnosed at incident and prevalent screens, respectively), while the lowest was found in women with non-proliferative benign breast disease (aHR, 2.39; 95%CI: 1.95-2.93, and 1.63; 95%CI: 1.32-2.02 for those diagnosed at incident and prevalent screens, respectively). Conclusion: Our study showed that the risk of breast cancer conferred by a benign breast disease differed according to type of screen (prevalent or incident). To our knowledge, this is the first study to analyse the impact of the screening type on benign breast disease prognosis.
publishDate 2020
dc.date.none.fl_str_mv 2020
2021
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/47746
http://dx.doi.org/10.1016/j.breast.2020.09.005
url http://hdl.handle.net/10230/47746
http://dx.doi.org/10.1016/j.breast.2020.09.005
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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